Response to injury of skin involved and uninvolved with psoriasis, and its relation to disease activity: Koebner and'reverse'Koebner reactions

Eyre, Russell W.; Krueger, Gerald G.

doi:10.1111/j.1365-2133.1982.tb00924.x

Cited by 118 publications

(78 citation statements)

References 14 publications

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“…Traditionally, epidermal hyperplasia and barrier dysfunction has been considered secondary to an initiating blood-borne factor (e.g., circulating T cells in psoriasis), or primary dermal irritation (50,51). Our studies suggest an alternative hypothesis that links dermal inflammation (including potential recruitment of blood-borne factors) to a primary insult in the epidermal barrier.…”

Section: Discussionmentioning

confidence: 76%

“…Our studies suggest an alternative hypothesis that links dermal inflammation (including potential recruitment of blood-borne factors) to a primary insult in the epidermal barrier. Superficial trauma is widely appreciated to be an antecedent of psoriasis (Koebner or isomorphic phenomenon) (50,52). Likewise, clinically uninvolved skin in atopic dermatitis displays a defective barrier (53).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice.

Wood¹,

Jackson²,

Elias³

et al. 1992

J. Clin. Invest.

427

342

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The disruption of the cutaneous permeability barrier results in metabolic events that ultimately restore barrier function. These include increased epidermal sterol, fatty acid, and sphingolipid synthesis, as well as increased epidermal DNA synthesis. Because tumor necrosis factor (TNF) and other cytokines are known products of keratinocytes and have been shown to modulate lipid and DNA synthesis in other systems, their levels were examined in two acute models and one chronic model of barrier perturbation in hairless mice. Acute barrier disruption with acetone results in a 72% increase in epidermal TNF 2.5 h after treatment, as determined by Western blotting. Furthermore, epidermal TNF mRNA was elevated ninefold over controls 2.5 h after acetone treatment. This elevation in TNF mRNA was maximal at 1 h after acetone, and decreased to control levels by 8 h. After tape stripping, a second acute model of barrier disruption that avoids application of potentially toxic chemicals, TNF mRNA was elevated fivefold over controls at 2.5 h. Moreover, the mRNA levels for epidermal IL-1 alpha, IL-1 beta, and granulocyte macrophage-colony-stimulating factor (GM-CSF) also were elevated several-fold over controls, after either acetone treatment or tape stripping, but their kinetics differed. GM-CSF mRNA reached a maximal level at 1 h after acetone, while IL-1 alpha and IL-1 beta were maximal at 4 h after treatment. In contrast, mRNAs encoding IL-6 and IFN gamma were not detected either in control murine epidermis or in samples obtained at various times after tape stripping or acetone treatment. The relationship of the cytokine response to barrier function is further strengthened by results obtained in essential fatty acid deficient mice. In this chronic model of barrier perturbation mRNA levels for epidermal TNF, IL-1 alpha, IL-1 beta, and GM-CSF were each elevated several-fold over controls. These results suggest that epidermal cytokine production is increased after barrier disruption and may play a role in restoring the cutaneous permeability barrier. (J. Clin. Invest. 1992. 90:482-487.) Key words: tumor necrosis factor.interleukin-1 * granulocyte macrophage-colony-stimulating factor * essential fatty acid deficiency Introduction The stratum corneum provides the cutaneous permeability

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice.

Wood¹,

Jackson²,

Elias³

et al. 1992

J. Clin. Invest.

427

342

View full text Add to dashboard Cite

show abstract

“…This finding is in contrast to patients with psoriasis, in whom a positive KP-e was positively correlated with the extent of psoriatic lesions. 26 This allowed us to conclude that in vitiligo, the KP-e does not have a predictive value to the extent of depigmentation.…”

Section: Commentmentioning

confidence: 99%

Association of the Köbner Phenomenon With Disease Activity and Therapeutic Responsiveness in Vitiligo Vulgaris

Njoo¹,

Das²,

Bos³

et al. 1999

Arch Dermatol

222

166

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“…The development of plaques of psoriasis is a multistage process that involves overt activation of the innate and adaptive immune systems (63)(64)(65)(66)(67)(68). According to current concepts, the release of endogenous DNA in combination with the anti-microbial protein LL37 is detected by plasmacytoid dendritic cells (DCs), resulting in the production of interferon-a (IFNa) (69,70).…”

Section: Plaque Development and The Immune Response In Psoriasismentioning

confidence: 99%

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

Girolomoni

Griffiths

Krueger

et al. 2014

Journal of Dermatological Treatment

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Psoriasis is an immune-mediated inflammatory disease (IMID) which may have a major impact on a patient's life, especially when the disease is moderate to severe. There is evidence that treatment of psoriasis during the first years is conservative and frequently based on topical agents which rarely clear lesions. Treatment with systemic agents including biologics is often undertaken only when topical agents have proved unsuitable, even in patients with moderate to severe disease. However, there is evidence that in other IMIDs (rheumatoid arthritis and Crohn's disease), targeted systemic treatment given early in the treatment pathway may improve long-term patient outcomes. We hypothesize that a patient-centered therapeutic approach, undertaken early in the psoriasis treatment pathway (''early intervention'') with the goal of complete clearance, may improve control of cutaneous symptoms and may also modify disease course and burden. Critical points to address when designing an early intervention study would include: the definition of psoriasis disease activity; patient selection; intervention selection; and dosing strategies.

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Response to injury of skin involved and uninvolved with psoriasis, and its relation to disease activity: Koebner and'reverse'Koebner reactions

Cited by 118 publications

References 14 publications

Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice.

Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice.

Association of the Köbner Phenomenon With Disease Activity and Therapeutic Responsiveness in Vitiligo Vulgaris

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

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