Response to Letter by Page and Chae

Background and Purpose-Prognostic significance of low-density lipoprotein cholesterol (LDL-C) in intracranial hemorrhage (ICH) is unclear. The objective of this study was to determine the association between LDL-C and mortality in ICH. Methods-Consecutive patients (nϭ88) presenting with ICH were included in the study. Lipid profile was obtained during the first hours after admission. We analyzed the impact of LDL-C on 90-day mortality using the Hazard Rate (HR) crude, analysis crude for trend by Mantel-Haenszel Test, Multiple Cox Proportional Hazards model, and analysis of survival curves. Association between LDL-C and severity markers of ICH were explored using Spearman correlation coefficient. Results-Low LDL-C levels were independently associated with death after intracranial hemorrhage (HRϭ3.07 (95% CI:1.04 to 9.02; Pϭ0.042) in multivariable analysis after controlling for confounding factors. Analysis for trend showed a significant association (XtϭϪ2.144; Pϭ0.032) by Mantel-Haenszel Test. Spearman analysis showed no correlation between LDL-C and variables that are markers of ICH severity: NIH score (rϭϪ0.091; Pϭ0.400), GCS score (rϭ0.136; Pϭ0.207), ICH volume (rϭ0.140; Pϭ0.192), and length of stay (rϭϪ0.111; Pϭ0.308). Conclusions-Low levels of LDL-C are independently associated with an increased risk of death in patients with brain hemorrhage. We have not found evidences that the levels of LDL-C can act as a biological marker of severity.

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Serum Cholesterol LDL and 90-Day Mortality in Patients With Intracerebral Hemorrhage

Ramírez-Moreno

Casado-Naranjo

Portilla

et al. 2009

Stroke

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Response to Letter by Page and Chae

Cited by 1 publication

References 11 publications

Serum Cholesterol LDL and 90-Day Mortality in Patients With Intracerebral Hemorrhage

Serum Cholesterol LDL and 90-Day Mortality in Patients With Intracerebral Hemorrhage

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