Response to Letter Regarding Article, “Coronary Heart Disease Mortality Declines in the United States From 1979 Through 2011: Evidence for Stagnation in Young Adults, Especially Women”

Wilmot, Kobina; O’Flaherty, Martı́n; Capewell, Simon; Ford, Earl S.; Vaccarino, Viola

doi:10.1161/circulationaha.115.020672

Cited by 82 publications

(95 citation statements)

References 4 publications

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“…4,5 Indeed, the risk of cardiovascular events has been shown to start at higher LVEF indices in women when compared with men, indicating that thresholds to pathologic state are gender dependent. 6 In addition, in view of the continuously growing elderly population in most countries, it becomes increasingly important to distinguish normal age-related changes in LV size and function from pathologic findings.…”

Section: Introductionmentioning

confidence: 99%

Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

Gebhard

Buechel

Stähli

et al. 2016

European Heart Journal - Cardiovascular Imaging

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BackgroundLeft ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender-and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking. Methods and results1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 + 12.4 years, range: 18 -92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (.50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 + 7.7% vs. 64.6 + 8.1%, P , 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 + 8.89% vs. 65.50 + 9.42%, P ¼ 0.004). Accordingly, a significant increase in LVEF was observed with age (P ¼ 0.005 for males and P , 0.001 for females), which was more pronounced in females (5.21%) than in males

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Section: Introductionmentioning

confidence: 99%

Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

Gebhard

Buechel

Stähli

et al. 2016

European Heart Journal - Cardiovascular Imaging

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show abstract

“…Recent adverse trends in young and middle aged adult cardiovascular morbidity and mortality, particularly in women, have been observed with those less than 55 years of age not sharing in the significant reductions in cardiovascular events observed in older individuals [17]. Higher all cause mortality rates have also been observed in white United States American males between 45 and 54 years of age [18].…”

Section: Impact Of Population Trends On Psychosocial Stressmentioning

confidence: 99%

Childhood Psychosocial Determinants of Cardiovascular Health

Sood

Gidding

2016

Curr Cardiovasc Risk Rep

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“…[17][18][19][20][21] An association between fertility therapy failure and longterm cardiovascular risk could provide insight into nontraditional risk factors potentially contributing to the stagnation in the reduction of cardiovascular mortality observed among young women. [22][23][24][25][26] We conducted the Investigation of Notable Failed Endeavours at Reproductive Treatment and Ischemic Long-term Events (INFERTILE) study to investigate whether fertility therapy failure is associated with subsequent adverse cardiovascular events.…”

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confidence: 99%