2020
DOI: 10.1161/circinterventions.120.009385
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Response to Letter Regarding Article, “Absence of Long-Term Benefit of Revascularization in Patients With Intermittent Claudication: Five-Year Results From the IRONIC Randomized Controlled Trial”

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Cited by 6 publications
(10 citation statements)
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“…These recommendations are based on data showing that there is a relatively low likelihood of limb loss associated with mild PAD 189 and that long-term improvements in symptomatology may be limited. 190 For example, recent data from the Invasive Revascularization or Not in Intermittent Claudication trial demonstrated that, after 5 years of follow-up, revascularization for claudication lost any early benefit and did not result in long-term health-related quality of life compared with best medical therapy. 190 Despite guidelines recommending medical management as the first-line therapy for claudication, recent registry data from the Vascular Quality Initiative demonstrate that 27% of all open bypass procedures and even a higher percentage of endovascular interventions are performed for claudication.…”
Section: Gaps and Challenges In Pad Managementmentioning
confidence: 99%
“…These recommendations are based on data showing that there is a relatively low likelihood of limb loss associated with mild PAD 189 and that long-term improvements in symptomatology may be limited. 190 For example, recent data from the Invasive Revascularization or Not in Intermittent Claudication trial demonstrated that, after 5 years of follow-up, revascularization for claudication lost any early benefit and did not result in long-term health-related quality of life compared with best medical therapy. 190 Despite guidelines recommending medical management as the first-line therapy for claudication, recent registry data from the Vascular Quality Initiative demonstrate that 27% of all open bypass procedures and even a higher percentage of endovascular interventions are performed for claudication.…”
Section: Gaps and Challenges In Pad Managementmentioning
confidence: 99%
“…The long-term results from several moderate-sized RCTs suggest that early advantages of endovascular revascularization over exercise may be lost over time and that patients undergoing intervention early are subject to a significantly larger number of procedures during follow-up. 58–61 Hence, the treatment approach to IC should be both staged and selective, in accordance with current guidelines.…”
Section: Evidence For Revascularization In Padmentioning
confidence: 98%
“…Finally, our search strategy yielded 22 reports of 9 relevant studies. [22][23][24][25][26][27][28][29][30] Data of longest follow-up from each study were used. Overall risk of bias was low for all studies (Supplemental Figure 1, Supplemental Digital Content 1, http://links.lww.com/SLA/E413).…”
Section: Search Resultsmentioning
confidence: 99%
“…Six RCTs did not describe the outcomes of our interest. Finally, our search strategy yielded 22 reports of 9 relevant studies 22–30 . Data of longest follow-up from each study were used.…”
Section: Resultsmentioning
confidence: 99%