Response to letter to Editor by Gatterer and Burtscher concerning splenic contraction in different situations

Schagatay, Erika; Holmström, Pontus

doi:10.1007/s00421-021-04704-6

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…5 ). In fact, our data contradict the recent series of letters to the editor by Schagatay and Holmström, ( 2021 ) and Engan et al ( 2021 ), who suggested that splenic emptying augments O 2 transport to active tissues (via RBC release), under all circumstances, including aerobic exercise. Our work also addresses, at least in part the on-going debate in the literature (Schagatay and Holmström, 2021 ; Gatterer and Burtscher 2021 ), regarding the role of the spleen in O 2 transport under different scenarios, including standardized laboratory conditions at sea level.…”

Section: Discussioncontrasting

confidence: 94%

“…However, the role of the spleen in O 2 transport during aerobic exercise has not been carefully studied. Moreover, direct evidence that splenic contraction also augments aerobic performance during exercise in humans is lacking, as there is still an on-going debate in the literature regarding the role of the spleen in O 2 transport under different scenarios (Gatterer and Burtscher 2021 ; Schagatay and Holmström 2021 ; Holmström et al 2021b ). Therefore, the correlation between the spleen volume changes, circulating RBC release and uptake parameters was explored here.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, this was not observed in splenectomized individuals (Bakovic et al 2003 ). Notably, compelling evidence that splenic emptying also enhances aerobic performance in humans is still missing, despite recent letters to the editor by Schagatay and Holmström ( 2021 ) and Engan et al ( 2021 ), suggesting that splenic emptying additionally facilitates O 2 transport to active tissues (via RBC release), under all circumstances, including aerobic exercise. Previous studies examining changes in spleen volume via ultrasound imaging during upright aerobic exercise were limited to pre/post data collection protocols (Sperlich et al 2015 ; Lodin-Sundström et al 2021 ), and the rate of splenic volume reduction remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants

et al. 2022

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Purpose The role of splenic emptying in O 2 transport during aerobic exercise still remains a matter of debate. Our study compared the differences in spleen volume changes between aerobically trained and untrained individuals during step-transition supine cycling exercise at moderate-intensity. We also examined the relationship between spleen volume changes, erythrocyte release, and O 2 uptake parameters. Methods Fourteen healthy men completed all study procedures, including a detailed medical examination, supine maximal O 2 uptake ( max.) test, and three step-transitions from 20 W to a moderate-intensity power output, equivalent to uptake at 90% gas exchange threshold. During these step-transitions pulmonary , near-infrared spectroscopy of the vastus lateralis , and cardiovascular responses were continuously measured. In parallel, minute-by-minute ultrasonic measurements of the spleen were performed. Blood samples were taken before and immediately after step-transition cycling. Results On average, max. was 10 mL kg min −1 ( p = 0.001) higher in trained compared to their aerobically untrained peers. In response to supine step-transition cycling, the splenic volume was significantly reduced, and the largest reduction (~ 106 to 115 mL, ~ 38%, p = 0.001) was similar in both aerobically trained and untrained individuals. Erythrocyte concentration and platelet count transiently increased after exercise cessation, with no differences observed between groups. However, the vastus lateralis deoxygenation amplitude was 30% ( p = 0.001) greater in trained compared to untrained individuals. No associations existed between: (i) spleen volumes at rest (ii) spleen volume changes (%), (iii) resting hematocrit and oxygen uptake parameters. Conclusion Greater splenic emptying and subsequent erythrocyte release do not lead to a slower , regardless of individual max. readings.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants

et al. 2022

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Spleen emptying does not correlate with faster oxygen kinetics during a step-transition supine cycling

Zubac

Obad

Bošnjak³

et al. 2021

Appl. Physiol. Nutr. Metab.

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This manuscript quantified spleen volume changes and examined the relationship between those changes and V̇O2 kinetics during supine cycling. Ten volunteers (age=22±3), completed three step-transitions from 20 W to their power output at 90% gas exchange threshold. Ultrasonic measurements of the spleen were performed each minute. The largest spleen volume reduction was 105 mL (p=.001). No associations existed between: i) spleen volumes at rest ii) spleen volume changes (%) and τV̇O2p. Larger resting spleen volume and greater emptying do not correlate with a faster τV̇O2p. Novelty: • Greater splenic contractions do not augment τV̇O2p, irrespective of spleen emptying and subsequent erythrocyte release.

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Response to letter to Editor by Gatterer and Burtscher concerning splenic contraction in different situations

Cited by 2 publications

References 6 publications

No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants

No differences in splenic emptying during on-transient supine cycling between aerobically trained and untrained participants

Spleen emptying does not correlate with faster oxygen kinetics during a step-transition supine cycling

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