Response to letter to editor regarding Immunoglobulin G4‐related disease in a dog

Moore, A Russell; Colopy, Lydia J.; Shiu, Kai‐Biu; Snyder, Laura A.; Avery, Anne C.; Rout, Emily D.

doi:10.1111/jvim.15733

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…90 The diagnostic criteria for IgG4-related disease(s) in dogs needs further clarification and consensus before a definitive diagnosis can be confirmed. 43,91 Also serum IgG4 concentrations have been noted to be high in other dogs with pancreatitis. 44 However, strict diagnostic criteria are required to prevent misclassification of other inflammatory or neoplastic diseases as IgG4-related disease.…”

Section: Autoimmune Pancreatitis Igg4-related Diseasementioning

confidence: 99%

“…Many of these dogs have concurrent keratoconjunctivitis sicca, xerostomia, proteinuria, and other immune‐mediated disorders 90 . The diagnostic criteria for IgG4‐related disease(s) in dogs needs further clarification and consensus before a definitive diagnosis can be confirmed 43,91 . Also serum IgG4 concentrations have been noted to be high in other dogs with pancreatitis 44 .…”

Section: Etiology and Potential Risk Factors For Pancreatitismentioning

confidence: 99%

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New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Cridge

Lim

Algül

et al. 2022

Veterinary Internal Medicne

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While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors for pancreatitis in dogs, allowing for improved awareness and detection of potential dog‐specific risk factors, which might guide the development of disease prevention strategies. Additionally, we review important advances in our understanding of the pathophysiology of pancreatitis and potential areas for therapeutic manipulation based thereof. The outcome of pathophysiologic mechanisms and the development of clinical disease is dependent on the balance between stressors and protective mechanisms, which can be evaluated using the critical threshold theory.

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Section: Autoimmune Pancreatitis Igg4-related Diseasementioning

confidence: 99%

Section: Etiology and Potential Risk Factors For Pancreatitismentioning

confidence: 99%

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Cridge

Lim

Algül

et al. 2022

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…26 Although these IgG4 + plasma cells were detected, there is no consensus on how to definitively diagnose IgG4-related disease in dogs and further investigation and validation is required. 42 To the authors' knowledge, no validated IHC for canine IgG4-related disease exists and so, at this stage, no further tests were performed on the histology samples available for the cases presented in this study.…”

Section: Discussionmentioning

confidence: 99%

Canine idiopathic orbital inflammation: A case series of four affected dogs (five orbits)

Freitas¹,

Taeymans²,

Knott³

et al. 2022

Veterinary Ophthalmology

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In humans, idiopathic orbital inflammation (IOI) is a diagnosis attributed to benign, inflammatory orbital conditions without identifiable local or systemic cause. We describe the clinical signs, imaging and histopathological findings, management and outcome of four dogs diagnosed with IOI. Methods: Multicentric retrospective study.Results: A total of four dogs (five orbits) of three different breeds (three cases were English Springer Spaniels [ESS] or ESS-cross) and ages ranging from 3 to 12 years were included. Initial presenting signs were unilateral and included exophthalmos, enophthalmos, globe deviation, thickening and protrusion of the third eyelid and conjunctival hyperemia. Computed tomography and magnetic resonance imaging identified heterogeneous space-occupying, contrast-enhancing orbital lesions in all cases. Sparing of the retrobulbar space was detected in four of five orbits. Histopathology revealed mixed inflammatory infiltrates of lymphocytes, plasma cells, and histiocytes. Immunohistochemistry was performed in two cases highlighting the presence of histiocytes and lymphocytes, predominantly T cells.Resolution of clinical signs was achieved in two cases managed with oral immunosuppressant medication (corticosteroids alone or combined with cyclosporine or azathioprine), one went into spontaneous remission, one resolved with topical corticosteroids, and one underwent exenteration. Recurrence occurred in two cases within 15 months of initial diagnosis and required further immunosuppressant medication. One case developed signs in the contralateral orbit within 8 months of presentation.Conclusions: IOI is an uncommon condition in dogs. Its diagnosis relies on the combination of advanced imaging and histology. As in humans, it appears that spontaneous remission and recurrence may occur requiring long-term immunosuppressant medication.

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Response to letter to editor regarding Immunoglobulin G4‐related disease in a dog

Cited by 2 publications

References 8 publications

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

Canine idiopathic orbital inflammation: A case series of four affected dogs (five orbits)

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