Response to “Letter to Fowler <i>et al.</i> 2008”

Fowler, Sharon P.; Stern, Michael P.; Williams, Ken; Hazuda, Helen P.; Hunt, Kelly J.; Resendez, Roy G.

doi:10.1038/oby.2008.624

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…ADI of all approved additives is the daily ingestion over a lifetime, without appreciable health risk, and is allocated by European Food Safety Authority (EFSA, 2009). Several studies bring in the question about the safety of food additives, mainly artificial sweeteners, reporting a similar, and sometimes stronger, relationship between the consumption of diet soda and the prevalence of metabolic syndrome, when compared to the consumption of regular soda (Nettleton et al, 2009;Fowler et al, 2008;Lutsey et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Risk assessment of additives through soft drinks and nectars consumption on Portuguese population: A 2010 survey

Diogo

Silva

Pena

et al. 2013

Food and Chemical Toxicology

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This study investigated whether the Portuguese population is at risk of exceeding ADI levels for acesulfame-K, saccharin, aspartame, caffeine, benzoic and sorbic acid through an assessment of dietary intake of additives and specific consumption of four types of beverages, traditional soft drinks and soft drinks based on mineral waters, energetic drinks, and nectars. The highest mean levels of additives were found for caffeine in energetic drinks, 293.5mg/L, for saccharin in traditional soft drinks, 18.4 mg/L, for acesulfame-K and aspartame in nectars, with 88.2 and 97.8 mg/L, respectively, for benzoic acid in traditional soft drinks, 125.7 mg/L, and for sorbic acid in soft drinks based on mineral water, 166.5 mg/L. Traditional soft drinks presented the highest acceptable daily intake percentages (ADIs%) for acesulfame-K, aspartame, benzoic and sorbic acid and similar value for saccharin (0.5%) when compared with soft drinks based on mineral water, 0.7%, 0.08%, 7.3%, and 1.92% versus 0.2%, 0.053%, 0.6%, and 0.28%, respectively. However for saccharin the highest percentage of ADI was obtained for nectars, 0.9%, in comparison with both types of soft drinks, 0.5%. Therefore, it is concluded that the Portuguese population is not at risk of exceeding the established ADIs for the studied additives.

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Section: Introductionmentioning

confidence: 99%

Risk assessment of additives through soft drinks and nectars consumption on Portuguese population: A 2010 survey

Diogo

Silva

Pena

et al. 2013

Food and Chemical Toxicology

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“…3 Several NAS compounds have been FDAapproved and are generally considered safe. 3 However, several studies suggested that counterintuitive links may exist between NAS consumption and the same ailments of the metabolic syndrome they are meant to prevent, such as weight gain, 4,5 cardiovascular disease, 6,7 and type II diabetes mellitus. 8,9 Several physiological mechanisms have been suggested for these phenomena, such as stimulation of intestinal sugar absorption, 10 disruption of the ability of sweet taste to signal caloric consequences, 11,12 an increase in appetite 13 and impaired glycemic or insulin responses.…”

Section: Introductionmentioning

confidence: 99%

Non-caloric artificial sweeteners and the microbiome: findings and challenges

et al. 2015

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These authors equally contributed to this work. N on-caloric artificial sweeteners (NAS) are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing controversy regarding their potential ability to promote metabolic derangements in some humans. We recently demonstrated that NAS consumption could induce glucose intolerance in mice and distinct human subsets, by functionally altering the gut microbiome. In this commentary, we discuss these findings in the context of previous and recent works demonstrating the effects of NAS on host health and the microbiome, and the challenges and open questions that need to be addressed in understanding the effects of NAS consumption on human health.

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Response to “Letter to Fowler et al. 2008”

Cited by 2 publications

References 5 publications

Risk assessment of additives through soft drinks and nectars consumption on Portuguese population: A 2010 survey

Risk assessment of additives through soft drinks and nectars consumption on Portuguese population: A 2010 survey

Non-caloric artificial sweeteners and the microbiome: findings and challenges

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