Response to Letter to the editor: ‘Psoriasis dermatitis: an overlap condition of psoriasis and atopic dermatitis in children’

Docampo, A.; Sánchez-Pujol, María José; Belinchón, Isabel; Miralles, J.; Lucas, Anna; García, L.; Cuesta, Laura; Berbegal, L.; Quecedo, Esther; Millán, Fernando; Esteve, Antonio Franco; Sánchez, Elena Moya; Díaz, Tania; Bernat, John Raymond; Betlloch, Isabel

doi:10.1111/jdv.15716

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…These results may indicate a large variety in the scope of AD and PS endotypes, which is currently being studied (15) Patients with concomitant AD and PS and PS and AD had a similar distribution of the affected skin areas. The results of this study are largely consistent with the observations of other authors (5). However, important clinical information is that boys and overweight patients are more likely to suffer from concomitant AD and PS.…”

Section: Discussionsupporting

confidence: 92%

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Atopic dermatitis and psoriasis as overlapping syndromes.

Bożek

Zając

Krupka

2020

Preprint

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Background: Concomitant atopic dermatitis (AD) and psoriasis (PS) are not common. However, both diseases are still of interest because of their comprehensive and diverse mechanism. The aim of the study was to present the clinical and immunological profile of patients with concomitant AD and PS coexist in comparison to patients with one of these diseases.Methods: In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2 yrs. were compared with similar 41 patients with only AD (5.3± 5.1 yrs) and with 28 with PS (6.4± 4.3 yrs). All patients underwent the dermatological examination including SCORAD and PASI questionnaire. TNF-α, IFN-γ, Il-2, Il-4, Il-5, Il-6, Il-8, Il-12, I-17, Il-18, Il-22, Il-33, TARC/CCL17 were measured by the use ELISA method and according manufacturer (ThermoFischer Scientific, US).Results: Patients with concomitant AD and PS were frequently boys or with overweight and with a proportional area distribution of skin lesions. A positive family history of atopic disease was more frequently reported by children with concomitant AD and PS, and with AD vs. PS. Significant differences were observed in the concentration of Il-17 in patients with AD and PS compared with that in AD or PS patients as follows: 9.1±3.7 pg/ml vs. 4.8±2.9 pg/ml and 5.2±3.9 pg/ml (PD vs. AD, p = 0.01; PD vs. PS, p = 0.03).Conclusion: AD and PS might coexist as overlapping disease. The role of T-helper 17 may be more meaningful than it appeared.

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Section: Discussionsupporting

confidence: 92%

“…The are evidence that AD and PS can co-exist as overlapping syndrome: psoriasis-dermatitis (1). This condition has various hypotheses of origin (5,6) The aim of the study was to assess clinical characteristics and cytokine pro le in children with AD and concomitant PS in comparison to those with AD or PS.…”

Section: Introductionmentioning

confidence: 99%

Atopic dermatitis and psoriasis as overlapping syndromes.

Bożek

Zając

Krupka

2020

Preprint

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“…As in other observations, there was a preponderance of males in the ADPS group, but it is difficult to explain this relationship. 4,11 A potential explanation is that a different immune and hormonal profile determine the emergence of such a disease.…”

Section: Discussionmentioning

confidence: 99%

Immunological differences between atopic dermatitis, psoriasis, and their combination in adult patients

Krupka

Bożek

Drewienkowska

et al. 2022

Allergol Immunopathol

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Objectives: The simultaneous occurrence of psoriasis (PS) dominated by Th1 lymphocytes and atopic dermatitis (AD) driven by Th2 cells is rare. This study analyzed a group of adult patients with concomitant PS and AD (ADPS) and compared the cytokine profiles of these patients with those of subjects with homogenous PS or AD and healthy controls. Materials and methods: All patients underwent dermatological examinations, including assess-ment of Scoring Atopic dermatitis (SCORAD) index and Psoriasis Area Severity Index (PASI) scores, TNF-α, IFN-γ, Il-2, Il-4, Il-5, Il-6, Il-8, Il-12, I-17A, Il-18, Il-22, Il-33, and T. There were 39 patients with a diagnosis of ADPS, 45 patients with PS, 47 patients with AD, and 42 healthy controls. Results: Patients with ADPS were mainly men with a proportional distribution of skin lesion areas. Significant differences were observed in the concentration of Il-17A between patients with ADPS and those with AD or PS and controls, which were as follows: 16.1 ± 5.4, 5.8 ± 2.1, 5.0 ± 3.1, and 3.3 ± 1.8 pg/mL, respectively. In conclusion, AD and PS might coexist as a combi-nation disease. The role of T helper 17 cells may be more essential than previously thought.

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“…2 Histologically, chronic psoriasis lesions share many overlapping features with AD, and some subsets of AD with IL-17 predominance (ie, intrinsic, pediatric, presentation in Asian patients) exhibit a psoriasiform appearance. 3,4 Atopic dermatitis and psoriasis are considered 2 distinct conditions because AD is a helper T cell (T H 2)driven disease with subsequent overproduction of IL-4 and IL-13 and psoriasis is a T H 17 cell-driven disease with overproduction of IL-17 3 ; however, the shared features of AD and psoriasis represent an underlying immunopathological spectrum 2,5,6 in which one condition can develop following treatment of the other condition (immunological shift in pathways), both conditions can occur at different times in a patient's life with alternating cycles of disease flares, or both conditions can coexist as an overlapping syndrome. 1,2 A retrospective study from 2012 to 2019 estimated the prevalence of concomitant AD and psoriasis in the United States at 1.3%, with AD following the diagnosis of psoriasis in 67% of cases.…”

Section: Case Reportmentioning

confidence: 99%

“…Concurrent AD and psoriasis-when both diseases flare simultaneously-is the rarest scenario. 2,5 Treatment modalities for AD include topical corticosteroids, which act on immune cells to suppress the release of proinflammatory cytokines, as well as dupilumab, which offers targeted blockade of involved cytokines IL-4 and IL-13. Psoriasis can be treated with multiple immune modulators, including topical corticosteroids and vitamin D analogs, as well as systemic medications that reduce T-cell activation and inflammatory cytokines through targeting of IFN-γ, IL-2, tumor necrosis factor α, IL-17, and IL-23.…”

Section: Dual Biologics For Concurrent Ad and Psoriasismentioning

confidence: 99%

Concurrent Atopic Dermatitis and Psoriasis Successfully Treated With Dual Biologic Therapy

Kaszycki

2023

Cutis

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Response to Letter to the editor: ‘Psoriasis dermatitis: an overlap condition of psoriasis and atopic dermatitis in children’

Cited by 7 publications

References 9 publications

Atopic dermatitis and psoriasis as overlapping syndromes.

Atopic dermatitis and psoriasis as overlapping syndromes.

Immunological differences between atopic dermatitis, psoriasis, and their combination in adult patients

Concurrent Atopic Dermatitis and Psoriasis Successfully Treated With Dual Biologic Therapy

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