Response to Letters Regarding Article, “Risks Associated With Statin Therapy: A Systematic Overview of Randomized Clinical Trials”

Prevalence of Musculoskeletal Pain and Statin Use

“…Our finding of a significant association between musculoskeletal pain and statin use are compatible with prior observational [10][11][12]14 and post-marketing surveillance studies of statins, but conflict with randomized clinical trials of statin therapy that show no significant association of statins with myalgia. 14 These differences may be caused by characteristics of participants involved in clinical trials, who may differ from patients using statins in the general population.…”

Clinical Perspective: Statins and the Liver—Harmful or Helpful?

“…However, since their introduction more than 20 years ago, the vast number of instances of statin-related hepatic events have been minor, reversible, asymptomatic, non-progressive ALT elevations. Looking back at the randomized clinical trials comprising more than 60,000 patients [33],while mild asymptomatic elevations were recorded in as many as 5 % of subjects, only about 1 % of subjects developed ALT elevations above 3 times the upper limit of normal, which was often not different from the incidence rate seen among placebo recipients [7,[33][34][35][36]. And when individual cases of significant hepatic injury seen in some of the clinical studies were scrutinized, the alleged statin was often exonerated [7].…”

Neue Aspekte der perioperativen Statintherapie

“…Ob dieser Anstieg mit einer statininduzierten Hepatotoxizität zusammenhängt, ist noch nicht abschließend geklärt [3,50]. Im Rahmen von Studien zum perioperativen Einsatz von Statinen sind Nebenwirkungen sehr selten [27,46,48]. So konnten Schouten et al [48] …”