Response to lithium of a cell surface ECTO-NOX protein with time-keeping characteristics

Kromkowski, Jessica; Hignite, Heather; Morré, Dorothy M.; Morré, D. James

doi:10.1016/j.neulet.2008.04.001

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…In BAT, the hydroquinone (NADH) oxidase ENOX1 was reduced by 1.7-fold in younger vs. older cohorts. The ENOX1 protein has been found to display a robust time-dependent enzymatic oscillation (Klein and Melton 1996;Jiang et al 2008;Kromkowski et al 2008). While the oscillations of ENOX1 are ultradian with a period length of 24 min, unlike the circadian clock, its periodicity can be modulated by lithium chloride, an inhibitor of GSK3β and known modifier of circadian activity (Klein and Melton 1996;Padiath et al 2004;Kromkowski et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Biological aging alters circadian mechanisms in murine adipose tissue depots

Sutton

Ptitsyn

Floyd

et al. 2012

AGE

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Biological aging alters the metabolism and volume of adipose tissue depots. Recent evidence suggests that circadian mechanisms play a role in promoting adipogenesis, obesity, and lipodystrophy.The current study compared cohorts of younger (5-9 months) and older (24-28 months) C57BL/6 mice as a function of biological age and circadian time. Advanced age significantly reduced the weight of the AGE (2013) 35:533-547 DOI 10.1007 Electronic supplementary material The online version of this article (doi:10.1007/s11357-012-9389-7) contains supplementary material, which is available to authorized users. brown, epididymal, inguinal, and retroperitoneal adipose depots but not total body weight. The older mice reduced their physical activity by >50% and delayed their activity initiation after light offset. The expressed transcriptome in brown and white adipose depots and liver of both cohorts displayed evidence of circadian rhythmicity; however, the oscillating mRNAs differed significantly between age groups and across tissues. The amplitude of Cry1, a component of the negative arm of the circadian apparatus, and downstream regulators such as Rev-erbα were elevated in the older relative to the younger cohorts as a function of circadian time. Overall, transcript levels differed significantly for 557 (inguinal adipose), 1,016 (liver), and 1,021 (brown adipose) expressed sequences between the cohorts as a function of age. These included transcripts encoding proteins within the canonical and non-canonical Wnt pathways. Since the Wnt pathway regulates adipose stem cell differentiation and shares a critical enzyme, glycogen synthase kinase 3β, with the circadian mechanism, the intersection between these two fundamental regulatory mechanisms merits further investigation with respect to biological aging of adipose tissues.

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