Response to Methylprednisolone Pulse Therapy in Refractory Childhood Pyoderma Gangrenosum : A Case Report

Abstract

Pyoderma gangrenosum is a rare, non-infectious, immune mediated, neutrophilic dermatosis associated with underlying systemic disease in 50% of cases. Brocq first described pyoderma gangrenosum in 1916.It is common in fourth and fifth decade. But childhood PG, reported was 4% percent. PG has been associated with systemic disorders like inflammatory bowel disease, arthritis, haematological disorders, autoimmune diseases, solid organ tumors, drugs etc. First line of management for PG is oral corticosteroids, dapsone and other sulphones. Other immunosuppresants are used as second line of treatment. Here we report a case of childhood PG not responding to conventional treatment but responded to methylprednisolone pulse therapy.