Response to OK-432 sclerotherapy in the treatment of cervical lymphangioma with submucosal extension to the airway

Manzini, Michelle; Schweiger, Cláudia; Manica, Denise; Kuhl, Gabriel

doi:10.1016/j.bjorl.2016.04.016

Cited by 8 publications

(11 citation statements)

References 5 publications

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“…Copley at al reported a case of CH in the axilla, which was managed by ultrasound guided aspiration but it was unsuccessful due to recurrence, which was then managed success fully by total excision [30]. Failure and complications of sclerotherapy due to immune response to OK-432 in multiloculated, microcystic and mixed variety of CH have also been frequently reported [31].…”

Section: Discussionmentioning

confidence: 99%

Adult-Onset Cystic Hygroma in Axilla: A Rare Case Report From India and Literature Review

Pandey¹,

Kumar²,

Maheshwari³

et al. 2021

IJMMR

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Background. Cystic hygroma (CH), occurs in 1/6000 live births and in 90% of cases develops in age less than 2 years old. They are mainly located in cervicofacial region. Adult-onset CH is very rare. Objective. The aim of this study is to review literature to discuss the clinical presentation, diagnosis, and treatment of CH in adults through a case report of unilocular CH in the axillary region in an adult male from India. Methods. A first case report of unilocular CH in axillary region in an adult male from India is being investigated. Results. Here we report a case of unilocular CH in the axillary region in a 49-year-old male with a 14x16x8 cm cystic swelling in left axilla with a history of aspiration failure. Contrast-enhanced MRI (CEMRI) showed well-defined thin walled, unilocular cystic lesion which appeared hyperintense on T2 & STIR and hypointense on T1W1 and showed thin peripheral rim of enhancement on post contrast images. The patient underwent surgical excision and the diagnosis of a pathological CH was established. His postoperative recovery was uneventful and had no evidence of recurrence. Conclusion. Due to rarity of adult-onset unilocular CH in axilla, its evaluation for prompt diagnosis and definitive treatment to prevent recurrence and complications is urgent. Furthermore, this is the first reported case from India which has been successfully managed at a peripheral hospital in Northeast-India and our report of this case contributes to the evidences supporting the role of CH in a differential diagnosis for masses in the adult axilla, especially in acute phase with no predisposing factors.

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Section: Discussionmentioning

confidence: 99%

Adult-Onset Cystic Hygroma in Axilla: A Rare Case Report From India and Literature Review

Pandey¹,

Kumar²,

Maheshwari³

et al. 2021

IJMMR

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“…These complications may be related to friction and trauma due to discomfort caused by the neck mass in children. Although 1.6-16% of lymphatic malformations subside naturally and 15-70% have mild symptoms and only need outpatient follow-up, 7 approximately 50% of cervical lymphatic malformations, especially those complicated by haemorrhage and infection, cause compression and distortion of important adjacent organs, affecting breathing, swallowing, and making sounds, and can be life-threatening. Therefore, surgery, radiotherapy, or interventional therapy must be carried out.…”

Section: Main Ndingsmentioning

confidence: 99%

“…Moreover, the incidence of complications from surgery is 19-33%, the postoperative recurrence rate is 53%, and the mortality rate is 6%. 7,27 Therefore, interventional sclerotherapy is a better choice for recurrent and surgically unresectable lesions, reducing tumour volume before surgery, reducing injury, and improving aesthetic appearance. 7,28 Sclerotherapy has thus become the primary treatment for cervical lymphatic malformations; however, it has side effects such as metabolic acidosis, hyperhaemoglobinaemia, and cellulitis.…”

Section: Main Ndingsmentioning

confidence: 99%

“…7,27 Therefore, interventional sclerotherapy is a better choice for recurrent and surgically unresectable lesions, reducing tumour volume before surgery, reducing injury, and improving aesthetic appearance. 7,28 Sclerotherapy has thus become the primary treatment for cervical lymphatic malformations; however, it has side effects such as metabolic acidosis, hyperhaemoglobinaemia, and cellulitis. 29 Therefore, patients with large-volume or multilocular cysts should undergo sclerotherapy in stages or for residual lesions after surgical resection to avoid toxic side effects.…”

Section: Main Ndingsmentioning

confidence: 99%

“…4,5 Its clinical manifestations depend on the in ltration location and growth rate, and approximately 15-70% of patients have mild symptoms. [6][7][8] Diagnosis is based on intracystic uid echoic, a thick of cystic wall, and the cyst location; additionally, medical history and clinical manifestations are helpful for diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonographic diagnosis, classification, and treatment of cervical lymphatic malformation in paediatric patients: a retrospective study

Wang

Geng

et al. 2020

Preprint

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Background: To explore the imaging features, key diagnostic points, classification, treatment, and prognosis of cervical lymphatic malformation. Methods: Overall, 320 patients diagnosed with cervical lymphatic malformation were retrospectively analysed in our hospital between 1 January 2014 and 31 December 2017. Imaging modalities included colour Doppler ultrasound, magnetic resonance imaging, and contrast-enhanced computed tomography. Cervical lymphatic malformations were classified by cyst diameter. Treatments included interventional therapy, surgery, and expectant treatment. Results: Cervical lymphatic malformation was identified in 320 of 1,192 patients with lymphatic malformation, the sensitivity of ultrasonographic diagnosis was 99.38% (318/320). Cervical lymphatic malformation was classified as mixed, macrocystic, and microcystic in 184 (57.5%), 117 (36.56%), and 19 (5.94%) patients, respectively. Sixty-four (20%), ten (3.12%), seven (2.19%), and three (0.94%) patients experienced intracystic haemorrhage, infection, concurrent intracystic haemorrhage and infection, and calcification, respectively. Among 260 (81.25%) patients who underwent interventional sclerotherapy, 163 (50.94%) received it once and 96 (30%) received it two or more times. Twenty-eight (8.75%), five (1.56%), and 27 (8.44%) patients underwent surgical resection, interventional sclerotherapy plus surgery, and expectant management, respectively. Conclusions: Ultrasonography is useful for diagnosing definitely cervical lymphatic malformation. Interventional therapy is the first choice for children with confirmed cervical lymphatic malformation.

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OK-432 Sclerotherapy of Giant Cervicomediastinal Cystic Hygroma

Wang¹,

Li³

et al. 2022

Journal of Craniofacial Surgery

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Cystic hygroma is one type of the benign malformations and typically located in the neck, clavicle, and others, in children under the age of 5 years. However, the incidence of giant cervicomediastinal giant cystic hygroma is very rare, especially in adulthood. Such a location and age make its diagnosis difficult because they are usually asymptomatic. Complete surgical resection seems impossible while multiple sites are involved. Herein, we present a case of giant cervicomediastinal cystic hygroma, describing the clinical presentation, radiographic features, and OK-432 sclerotherapy. In conclusion, repeated OK-432 sclerotherapy may be an effective treatment option in giant cervicomediastinal cystic hygroma. Pay close attention to patient’s symptoms and vital signs, adjusting the OK-432 dose throughout the process.

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Response to OK-432 sclerotherapy in the treatment of cervical lymphangioma with submucosal extension to the airway

Cited by 8 publications

References 5 publications

Adult-Onset Cystic Hygroma in Axilla: A Rare Case Report From India and Literature Review

Adult-Onset Cystic Hygroma in Axilla: A Rare Case Report From India and Literature Review

Ultrasonographic diagnosis, classification, and treatment of cervical lymphatic malformation in paediatric patients: a retrospective study

OK-432 Sclerotherapy of Giant Cervicomediastinal Cystic Hygroma

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