Response to Smith and Brogly <i>et al</i>. commentaries on Zedler <i>et al</i>.

Joyce, Andrew; Zedler, Barbara; Amick, Halle R; Murrelle, E. Lenn; Jones, Hendrée E.

doi:10.1111/add.13608

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“…Inputs for this bias analysis have been previously questioned as the assumptions informing these are subjective and results vary by slight changes in their inputs. 35 Our findings extend this work by using an internal validation study to inform the bias parameters and draw conclusions from one study center limiting heterogeneity in treatment practices. Using more conservative bias parameters informed from the validation cohort slightly weakened the impact of unmeasured confounding on our results by comparison.…”

Section: Discussionsupporting

confidence: 64%