Response To Tissue Injury

Peled, Ziv M.; Chin, Gyu S.; Liu, Wei; Galliano, Robert; Longaker, Michael T.

doi:10.1016/s0094-1298(20)32755-3

Cited by 30 publications

(13 citation statements)

References 84 publications

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“…In human wound healing, an incisional wound is primarily reepithelialized within 24 to 48 hours. 18 In our study, epithelial proliferation was prominent on day 1 after surgery, and this period was similar to that in studies of mouse corneal epithelium19 and oral keratinocytes in vitro.l? Fibroblasts constitute the primary mesen-chymal cell type, and they migrate and proliferate in the cutaneous wound, stimulated by cytokines such as platelet-derived growth factor."…”

Section: Discussionsupporting

confidence: 88%

Cell Production in Injured Vocal Folds: A Rat Study

Tateya

Tateya²,

Lim³

et al. 2006

Ann Otol Rhinol Laryngol

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Section: Discussionsupporting

confidence: 88%

Cell Production in Injured Vocal Folds: A Rat Study

Tateya

Tateya²,

Lim³

et al. 2006

Ann Otol Rhinol Laryngol

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“…Excessive deposition of disorganized collagen type I has been observed during the remodeling phase of dermal injury. 18,19 In the current experiment, collagen type I expression was significantly increased at 72 hours after injury compared to 2 and 4 hours after injury, and nonsignificantly increased at 72 hours after injury compared to control. Collagen type III expression was significantly increased at 72 hours after injury compared to 2, 4, and 8 hours, and significantly increased at 24 and 48 hours after injury compared to 4 hours after injury.…”

Section: Discussionmentioning

confidence: 40%

Extracellular Matrix Gene Expression after Vocal Fold Injury in a Rabbit Model

Rousseau

Ge²,

Ohno³

et al. 2008

Ann Otol Rhinol Laryngol

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Objectives We determined the expression of matrix metalloproteinase (MMP)–1, MMP-9, collagen types I and III, and fibronectin from rabbit vocal folds after injury. Methods Thirty rabbits were involved in this study. Five animals were assigned to each time period. Noninjured vocal fold specimens were collected as a control. Gene expression was analyzed at 2, 4, 8, 24, 48, and 72 hours after injury by use of real-time polymerase chain reaction. Results Compared to 2 hours after injury, MMP-1 expression was increased at 4, 8, 24, 48, and 72 hours. Compared to 4 hours, MMP-1 expression was increased at 8, 24, 48, and 72 hours. Compared to the control specimens, MMP-9 expression was increased at 4, 8, 24, 48, and 72 hours. Compared to 2 hours, MMP-9 expression was increased at 4, 8, 24, 48, and 72 hours. Compared to 2 and 4 hours, collagen type I expression was increased at 72 hours. Collagen type III expression was increased at 72 hours compared to 2, 4, and 8 hours. Compared to 2 hours, fibronectin expression was increased at 24, 48, and 72 hours. Conclusions Results revealed time-dependent changes in expression of MMP-1, MMP-9, collagen types I and III, and fibronectin from rabbit vocal folds after injury. Future experiments are planned to investigate the effects of phonation on expression of these genes after injury.

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“…Epithelial cell migration and proliferation are stimulated by the absence of neighboring cells at the wound margin and/or by the release of growth factors, concomitant with the increase in receptors for growth factors in epithelial cells. 4 Since basement membrane is absent, epithelial cells use the provisional matrix that comprises mainly fibrin and fibronectin as substrata for migration. 3 Complete reepithelization allows the restoration of skin barrier functions; these include defense against microorganisms, protection from trauma, and prevention of water loss.…”

Section: Reepithelization Remodeling and Scar Formationmentioning

confidence: 99%

“…These recruit inflammatory cells such as neutrophils and macrophages as well as fibroblasts and endothelial cells to the site of the wound. 2,4 During granulation tissue formation, fibroblasts and endothelial cells proliferate and move into the wound space leading to extracellular matrix deposition and angiogenesis, which are typical features of granulation tissue formation. 2 New blood vessels are important to sustain the development of granulation tissue.…”

mentioning

confidence: 99%

Cutaneous Wound Healing: Myofibroblastic Differentiation and in Vitro Models

Amadeu

Coulomb

Desmoulière

et al. 2003

The International Journal of Lower Extremity Wounds

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Wound healing is an interactive, dynamic 3-phased process. During the formation of granulation tissue, many fibroblastic cells acquire some morphological and biochemical smooth muscle features and are called myofibroblasts. Myofibroblasts participate in both granulation tissue formation and remodeling phases. Excessive scarring, which is a feature of impaired healing, is a serious health problem that may affect the patient's quality of life. The treatment costs of such lesions are high, and often, the results are unsatisfactory. To understand the wound healing process better and to promote improvement in human healing, models are needed that can predict the in vivo situation in humans. In vitro models allow the study of cell behavior in a controlled environment. Such modeling partitions and reduces to small scales behavior perceived in vivo. This article is focused on "fibroblasts". In vitro models to study wound healing, the role of (myo)fibroblasts, and skin reconstruction in tissue replacement and promotion of wound healing are discussed.

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Response To Tissue Injury

Cited by 30 publications

References 84 publications

Cell Production in Injured Vocal Folds: A Rat Study

Cell Production in Injured Vocal Folds: A Rat Study

Extracellular Matrix Gene Expression after Vocal Fold Injury in a Rabbit Model

Cutaneous Wound Healing: Myofibroblastic Differentiation and in Vitro Models

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