Response to Ultraviolet Radiation in a Simple Eukaryote (Yeast): Genetic Control and Biological Consequences

The Second ECVAM Workshop on Phototoxicity Testing

“…When using yeast, DNA damage can be demonstrated by comparing the responses of DNA repair-deficient strains with those of DNA repair-competent strains (37). In this way, even the specific mechanism of photoinduced lethality can be assessed, since mutant strains are available in all known DNA repair pathways (38).…”

“…The use of such mutants can significantly improve the sensitivity of the test. Furthermore, photomutagenicity and mitotic recombination can readily be assessed (37,39).…”