“…An increase in GST activity was found in the hepatopancreas of Chasmagnathus granulatus after MCs exposure representing a greater detoxification capacity through conjugation of MCs with glutathione (GSH) (Pinho et al, 2003). The depletion of the hepatic GSH after exposure to MC-LR was observed in the studies with goldfish (Xu et al, 1998) and common carp (Li et al, 2003). On the other hand, several recent studies have shown that exposure to MCs or to microcystic cyanobacterial extract results in transient elevation of intracellular GSH content, both in vitro (Ding et al, 2000) and in vivo (Gehringer et al, 2004).…”