Responses of IGF-I to endogenous increases in growth hormone after heavy-resistance exercise

Kraemer, William J.; Aguilera, B. A.; Terada, Makoto; Newton, Robert U.; Lynch, J. M.; Rosendaal, Gonny; McBride, Jeffrey M.; Gordon, Scott E.; Häkkinen, Keijo

doi:10.1152/jappl.1995.79.4.1310

Cited by 104 publications

(65 citation statements)

References 22 publications

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“…The indisputable importance of the hippocampus in learning and memory and the role of BDNF in mediating hippocampal synaptic plasticity are well established [17][18][19][20]; while additional evidence indicates a role for insulin-like growth factor (IGF-1) in mediating the cognitive effects of exercise [21][22][23]. Interestingly, serum BDNF concentration has repeatedly been reported to increase following exercise in humans [9,[24][25][26] (for review see [27]), while IGF-1 responses to exercise are more variable [28][29][30].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males

Griffin

Mullally

Foley

et al. 2011

Physiology & Behavior

438

324

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Physical activity has been reported to improve cognitive function in humans and rodents, possibly via a brain-derived neurotrophic factor (BDNF)-regulated mechanism. In this study of human subjects, we have assessed the effects of acute and chronic exercise on performance of a face-name matching task, which recruits the hippocampus and associated structures of the medial temporal lobe, and the Stroop word-colour task, which does not, and have assessed circulating concentrations of BDNF and IGF-1 in parallel. The results show that a short period of high-intensity cycling results in enhancements in performance of the face-name matching, but not the Stroop, task. These changes in cognitive function were paralleled by increased concentration of BDNF, but not IGF-1, in the serum of exercising subjects. 3 weeks of cycling training had no effect on cardiovascular fitness, as assessed by VO 2 scores, cognitive function, or serum BDNF concentration. Increases in fitness, cognitive function and serum BDNF response to acute exercise were observed following 5 weeks of aerobic training. These data indicate that both acute and chronic exercise improve medial temporal lobe function concomitant with increased concentrations of BDNF in the serum, suggesting a possible functional role for this neurotrophic factor in exercise-induced cognitive enhancement in humans.

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Section: Accepted M Manuscriptmentioning

confidence: 99%

Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males

Griffin

Mullally

Foley

et al. 2011

Physiology & Behavior

438

324

View full text Add to dashboard Cite

show abstract

“…In contrast to this view, Wallace et al demonstrated similar relative changes in serum levels of tIGF-I, IGFBP-3 and acid-labile subunit (ALS) during a 30-min bout of moderate exercise [5]. However, increased IGF-I concomitantly with unchanged IGFBP-3 has also been reported [22]. …”

Section: Acute Changes In Total Igf-i In Relation To a Bout Of Exercisementioning

confidence: 99%

Exercise and Circulating Insulin-Like Growth Factor I

Berg

Bang²

2004

Horm Res Paediatr

103

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Determinations of serum concentrations of total insulin-like growth factor I (tIGF-I) are important in the diagnosis, monitoring of treatment and safety evaluation of patients with growth disorders and/or metabolic disease. It is well established that tIGF-I status varies over time. Changes in tIGF-I levels in relation to an acute bout of exercise or repeated bouts, known as training, are likely to contribute to this variation. Serum tIGF-I has also been found to be of predictive value in growth prediction models employed before the start of growth hormone (GH) treatment. Furthermore, IGF-I generation tests have been suggested to be of value in the assessment of the growth response to GH administration in patients suspected of GH deficiency with or without some degree of GH insensitivity. This is discussed elsewhere in this issue. Recent progress in our understanding of growth hormone-dependent and -independent expression of the IGF1 gene in skeletal muscle and the role of sufficient energy intake during training for muscle and liver generation of IGF-I raises important questions regarding their relative contribution to the circulating pool of IGF-I. The present review is focused on circulating levels of tIGF-I in relation to a single bout of exercise or to a period of training. In addition, the expression of IGF-I locally in muscle in response to these stimuli will be discussed.

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“…The effects of exercise on the GH/IGF-I axis have been investigated. A large number of studies indicate that GH levels increase 10 minutes after the beginning of training and may increase up to 100-fold, especially in response to anaerobic exercise and hypoxia [24][25][26] . Daytime exercise has also been shown to increase GH secretion during sleep 27 .…”

Section: Gh Abusementioning

confidence: 99%

“…The physiological increase in GH levels seen in normal exercise makes it hard to differentiate this increase from that caused by external GH administration, as in doping situations. The reports of the effect of exercise upon IGF-I have also been conflicting, some of them showing no increase 26,29 , while in others 30,31 IGF-I was increased in a manner dependent on the exercise intensity.…”

Section: Gh Abusementioning

confidence: 99%