1986
DOI: 10.1038/ki.1986.193
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Responses of in vivo renal microvessels to dopamine

Abstract: The split hydronephrotic kidney preparation was used to directly observe the effects of locally applied dopamine on the in vivo diameters of renal vessels. Dopamine (1 X 10(-6) to 3 X 10(-5) M) produced a concentration-dependent dilation of the arcuate and interlobular arteries and afferent arterioles. Efferent arterioles near the glomeruli also dilated to dopamine but the dilation was less than that of the preglomerular vessels. Higher dopamine concentrations (3 X 10(-4) and 1 X 10(-3) M) produced more variab… Show more

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Cited by 69 publications
(27 citation statements)
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“…At low concentrations, dopamine activates D1 and D2 receptors and dilates interlobular arteries and both the afferent and efferent arterioles, resulting in an increased renal blood flow and a marked natriuretic response. At high concentrations, however, dopamine induces renal vasoconstriction via activation of the ␣-adrenergic receptors (22,29). We previously demonstrated that dopamine is a preferred physiological substrate of PMAT (5).…”
Section: Discussionmentioning
confidence: 99%
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“…At low concentrations, dopamine activates D1 and D2 receptors and dilates interlobular arteries and both the afferent and efferent arterioles, resulting in an increased renal blood flow and a marked natriuretic response. At high concentrations, however, dopamine induces renal vasoconstriction via activation of the ␣-adrenergic receptors (22,29). We previously demonstrated that dopamine is a preferred physiological substrate of PMAT (5).…”
Section: Discussionmentioning
confidence: 99%
“…Dopamine is synthesized in the proximal tubule and is released as a paracrine and autocrine hormone to act on different receptors in the renal tubules, glomeruli, and renal blood vessels (2,29). Dopamine exerts profound effects on renal hemodynamics in a dosedependant manner (22,29). At low concentrations, dopamine activates D1 and D2 receptors and dilates interlobular arteries and both the afferent and efferent arterioles, resulting in an increased renal blood flow and a marked natriuretic response.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…hydronephrotic kidney of the rat [4], thus supporting the Introduction concept of a vasodilating effect of specific dopaminergic D 1 -receptor activation, which at higher doses is opposed by In anaesthetized dogs [1] and rats [2], low doses of dopamine decreased renal vascular resistance, whereas higher doses an action of a-adrenergic receptors [5,6]. Another important effect of dopamine, which does not occur with other caused vasoconstriction.…”
mentioning
confidence: 77%
“…This effect can be largely explained by a direct vasodilatating action on renal arterioles secondary to stimulation of vascular DAI receptors [2,25].…”
Section: Methodsmentioning
confidence: 99%