2020
DOI: 10.3389/fcell.2020.603392
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Responses of Intestinal Microbiota and Immunity to Increasing Dietary Levels of Iron Using a Piglet Model

Abstract: Iron is an essential metal for both animals and microbiota. In general, neonates and infants of humans and animals are at the risk of iron insufficiency. However, excess dietary iron usually causes negative impacts on the host and microbiota. This study aimed to investigate overloaded dietary iron supplementation on growth performance, the distribution pattern of iron in the gut lumen and the host, intestinal microbiota, and intestine transcript profile of piglets. Sixty healthy weaning piglets were randomly a… Show more

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Cited by 15 publications
(7 citation statements)
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References 51 publications
(58 reference statements)
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“…Interestingly, previous literature indicated a possible positive correlation between Actinobacteria and PC(39:6), 73 which match what we have observed here of PC(39:6) with Enterorhabdus. In addition, a link or possibly a positive correlation between the abundance of Lactobacillus and the host's absorption/absorption rate of Fe was observed, 74,75 which matches our study of a slightly greater (although not significant) abundance of Lactobacillus in the Th3/+ mouse compared to the control group. Nevertheless, establishing causality between altered intestinal microbiome and metabolic dysfunction requires follow-up studies involving recolonization of germ-free or antibiotics-treated Th3/+ mice.…”
Section: G U R Esupporting
confidence: 87%
“…Interestingly, previous literature indicated a possible positive correlation between Actinobacteria and PC(39:6), 73 which match what we have observed here of PC(39:6) with Enterorhabdus. In addition, a link or possibly a positive correlation between the abundance of Lactobacillus and the host's absorption/absorption rate of Fe was observed, 74,75 which matches our study of a slightly greater (although not significant) abundance of Lactobacillus in the Th3/+ mouse compared to the control group. Nevertheless, establishing causality between altered intestinal microbiome and metabolic dysfunction requires follow-up studies involving recolonization of germ-free or antibiotics-treated Th3/+ mice.…”
Section: G U R Esupporting
confidence: 87%
“…This would suggest that children who received supplementation in the last 12 months and who present diarrhoea could be receiving excess Fe. The excessive Fe concentrations not being absorbed in the duodenum would enter the colon and be used by pathogenic bacteria to the detriment of commensal bacteria (31) . The amount of Fe in supplementation modifies the composition of the infant gut microbiota and increases faecal calprotectin levels, a marker of gut inflammation associated with an increased incidence of diarrhoea (23) .…”
Section: Discussionmentioning
confidence: 99%
“…However, iron is a factor that causes the Fenton reaction [13], and iron administration cause energy depletion in piglets with immature oxidative stress defense systems [32]. Therefore, setting the iron dosage according to the rearing condition of piglets is a very important issue in iron-administered rearing [10,11,[33][34][35][36].…”
Section: Physiological Effectmentioning
confidence: 99%
“…In piglet rearing, iron supplements are administered to piglets to prevent iron deficiency anemia during the growth process [10][11][12]. However, since iron is a factor that causes the Fenton reaction [13], piglets with immature oxidative stress defense systems may exhaust energy to cope with such stress.…”
Section: Introductionmentioning
confidence: 99%