Responses of neuronal nitric oxide synthase expression in the brainstem to electroacupuncture Zusanli (ST 36) in rats

Ma, Sheng-Xing; Ma, Jun; Moise, Georgette; Li, Xiyan

doi:10.1016/j.brainres.2004.12.029

Cited by 37 publications

(35 citation statements)

References 33 publications

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“…Wu et al [49] showed that acupuncture at VB-34 (Yanglingquan) results in the reduction of the SBP and prevented the hypertrophy of the heart muscle cells in spontaneously hypertensive rats (SHR). Similarly, EA at ST-36 (Zusanli) for 20 min promoted a depressant effect on the MAP in rats with induced hypertension, mediated by NO in periaqueductal gray substance through activation of inhibitors of the sympathetic system and the mitigation of cardiac activity [18,29,33] . MO at BL-15 (Xinxhu) and BL-27 (Xiaochangshu) points in SHR rats resulted in a decrease in MAP [25] .…”

Section: Discussionmentioning

confidence: 99%

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Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

Paterno

Freire

Soares³

et al. 2008

Kidney Blood Press Res

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Background/Aim: Chronic kidney disease is a worldwide public health problem and the prevention of its progression is still a major challenge in nephrology. Specific therapies that inhibit or attenuate this process are neither available nor satisfactory. Traditional Chinese medicine has been increasingly recognized as an effective therapeutic approach in several fields of medicine. The aim of this study was to investigate the effects of electroacupuncture (EA) and moxibustion (MO) in an experimental model of progressive renal disease in rats. Methods: Twenty-one male Wistar rats were submitted to 5/6th nephrectomy (NX) and assessed 8 weeks later and were divided into three groups: NX = only 5/6 NX, NX-AS = 5/6 NX and a 20-min EA-MO session in sham points, and NX-AM = 5/6 NX and a 20-min EA-MO session in three real acupuncture points. The treatment consisted of 16 sessions twice a week. Renal function, urine volume, serum creatinine, 24-hour proteinuria, direct and indirect blood pressure, glomerulosclerosis and tubulointerstitial fibrosis indices were assessed. Results: The NX-AM group showed a significant decrease in all investigated parameters when compared to the control groups. Conclusion: Our results suggest that EA and MO attenuated the progression of renal disease in the experimental model of 5/6 NX.

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Section: Discussionmentioning

confidence: 99%

“…The choice of these acupoints was based on their reported abilities to produce hypotensive responses as well as to participate in the central regulation of renal and cardiovascular responses [16,18,22,25,29] . Zusanli (ST-36) point also promotes analgesic and anti-inflammatory effects.…”

Section: Ea and Momentioning

confidence: 99%

Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

Paterno

Freire

Soares³

et al. 2008

Kidney Blood Press Res

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“…[13][14][15]26,27 Whether and how these neural-humoral factors are involved in mediating neural plasticity in somatic motor function remain to be examined.…”

Section: Discussionmentioning

confidence: 99%

“…It is conceivable that this unique mechanism, although still unclear, would relate to the effects of afferent inputs associated with the stimulation. Cumulative evidence indicates that afferent inputs during acupuncture, electroacupuncture, or transcutaneous ES may activate various supraspinal regions in the CNS, 24,25 affect secretion of neurotransmitters or neuropeptides, 14,26,27 and alter excitability and plasticity of the motor system. 28,29 For example, one recent study demonstrated that acupuncture with the "lifting and thrusting technique" at the acupoint Shousanli (LI-10) on the right forearm for 10 to 15 minutes significantly facilitated the transcranial magnetic stimulation evoked potential (MEP) recorded from the right first dorsal interosseous muscle.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Effect of Unilateral Electroacupuncture on Muscle Strength

Huang

Zhou

Lü

et al. 2007

The Journal of Alternative and Complementary Medicine

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Objectives: This study aimed to examine the bilateral effect of 4 weeks of unilateral electroacupuncture on leg muscle strength.Design: The effect of unilateral electroacupuncture at two selected acupoints, Zusanli (ST-36) and Xiajuxu (ST-39), which are located on the anterior tibialis muscle, on dorsiflexion strength was evaluated by statistical analyses of the interactions between the muscle strength pre and post 4 weeks of intervention, between the two legs, and between an experimental and a control group.Settings/location: The trial was carried out in the exercise rehabilitation laboratory at Tianjin University of Sport.Subjects: Thirty (30) healthy men with an average age of 20.9 Ϯ 2.98 (SD) years were randomly allocated into an electroacupuncture group (EG) and a control group (CG). They were physically active, but without specific strength training or previous experience of acupuncture.Interventions: Participants in the EG were given 3 sessions of electroacupuncture per week. In each session, the electroacupuncture was applied to the right leg at the acupoints with 8 duty cycles of 1 minute on and 1 minute off, pulse width of 1 millisecond, frequency of 40 Hz, and intensity of 30-40 V. Participants in the CG group kept their normal daily activities without additional intervention.Outcome measures: The maximum strength in dorsiflexion of each leg was examined by having participants lift weights in the range of motion of ϳ20°at the ankle joint.Results: Repeated-measures analysis of variance with Bonferroni adjustment detected significant increase in strength of both legs (right 21.3%, left 15.2%) in the EG (p Ͻ 0.05) and the increase was significantly higher than that of the CG (p Ͻ 0.05). The CG showed no significant change (right 3.0%, left 4.8%), post-treatment.Conclusions: Unilateral electroacupuncture at the selected acupoints improved muscle strength of both limbs. These findings may have implications in physical therapy and rehabilitation settings. 539

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“…Traditionally, hypertension in CKD was viewed as largely volume-dependent, but now there is increasing evidence that the activation of the SNS often accompanies CKD and, therefore, could contribute to elevation of arterial pressure, including its influence on fluid retention. The beneficial effect of EA-MO on blood pressure has been confirmed by several clinical and experimental studies described in the literature [7,35,36,37,38,39,40,41]. …”

Section: Discussionmentioning

confidence: 59%

Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats

Paterno¹,

Bergamaschi

Campos

et al. 2012

Kidney Blood Press Res

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Background/Aim: Chronic kidney disease (CKD) is an increasing major public health problem worldwide. The sympathetic nervous system and nitric oxide play an important role in the pathogenesis of CKD. Traditional Chinese medicine has accumulated thousands of years of therapeutic experiences. Electroacupuncture (EA) and moxibustion (MO) are two such therapeutic strategies. The aim of this study was to investigate the renal and hemodynamic effects of EA-MO in an experimental model of a CKD. Methods: Male Wistar rats submitted to 5/6th nephrectomy (5/6 NX) were studied for 8 weeks. There were four groups: (1) control, normal rats; (2) NX, 5/6 NX only; (3) NX-AS, 5/6 NX and EA-MO session using sham points, and (4) NX-AM, 5/6 NX and EA-MO session using real acupoints. Biochemical and blood pressure studies, renal sympathetic nerve activity measurements, nitric oxide levels and the histopathological indices were assessed. Results: The EA- and MO-treated group presented significant improvement in all measured functional and histopathological parameters. Conclusion: These findings suggest that EA-MO had beneficial effects on CKD. This effect was probably achieved by the modulation of the renal sympathetic nerve activity and nitric oxide levels, leading to decreased blood pressure, which is associated with less proteinuria.

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Responses of neuronal nitric oxide synthase expression in the brainstem to electroacupuncture Zusanli (ST 36) in rats

Cited by 37 publications

References 33 publications

Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

Bilateral Effect of Unilateral Electroacupuncture on Muscle Strength

Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats

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