Responses of neurons in the dorsal nucleus of the lateral lemniscus of cat to binaural tonal stimulation.

Brugge, John F.; Anderson, D. J.; Aitkin, Lindsay

doi:10.1152/jn.1970.33.3.441

Cited by 181 publications

(77 citation statements)

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“…Histological reconstruction of the midbrain and brain stem of this animal confirmed the location of an electrolytic lesion at this neuron's recording site to be in the DNLL. Neurons in the DNLL, which is a GABAergic projection nucleus to the IC (Adams and Mugnaini 1984;Batra and Fitzpatrick 2002;Kelly and Li 1997;Zhang et al 1998), show a high degree of phase-locking and high, sustained discharge rates Brugge et al 1970) compared with IC neurons, as Fig. 5B suggests.…”

Section: Sensitivity To the Periodicity Of Am Sounds Below The Icmentioning

confidence: 85%

Neural Sensitivity to Periodicity in the Inferior Colliculus: Evidence for the Role of Cochlear Distortions

McAlpine

2004

Journal of Neurophysiology

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McAlpine, David. Neural sensitivity to periodicity in the inferior colliculus: evidence for the role of cochlear distortions. J Neurophysiol 92: 1295-1311, 2004. First published May 5, 2004 10.1152/ jn.00034.2004. Responses of low characteristic-frequency (CF) neurons in the inferior colliculus were obtained to amplitude-modulated (AM) high-frequency tones in which the modulation rate was equal to the neuron's CF. Despite all spectral components lying outside the pure tone-evoked response areas, discharge rates were modulated by the AM signals. Introducing a low-frequency tone (CF Ϫ 1 Hz) to the same ear as the AM tones produced a 1-Hz beat in the neural response. Introducing a tone (CF Ϫ 1 Hz) to the opposite ear to the AM tone also produced a beat in the neural response, with the beat at the period of the interaural phase difference between the CF Ϫ 1 Hz tone in one ear, and the AM rate in the other ear. The monaural and interaural interactions of the AM signals with introduced pure tones suggest that AM tones generate combination tones, (inter-modulation distortion) on the basilar membrane. These interact with low-frequency tones presented to the same ear to produce monaural beats on the basilar membrane, modulating the responses of inferior colliculus (IC) neurons on the 1-Hz period of the monaural beats or interacting binaurally with neural input generated in response to stimulation of the opposite ear. The auditory midbrain appears to show a robust representation of cochlear distortions generated by amplitude-modulated sounds.

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Section: Sensitivity To the Periodicity Of Am Sounds Below The Icmentioning

confidence: 85%

Neural Sensitivity to Periodicity in the Inferior Colliculus: Evidence for the Role of Cochlear Distortions

McAlpine

2004

Journal of Neurophysiology

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“…First, as in other mammals, it is part of the binaural pathway and contains many EI cells (Brugge et al, 1970;Covey, 1993;Markovitz and Pollak, 1993;Kelly et al, 1998). Second, many EI cells in the gerbil DNLL show persistent inhibition evoked by binaural signals that favor the ear ipsilateral to the DNLL.…”

Section: Discussionmentioning

confidence: 98%

Inhibiting the Inhibition: A Neuronal Network for Sound Localization in Reverberant Environments

et al. 2007

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The precedence effect describes the phenomenon whereby echoes are spatially fused to the location of an initial sound by selectively suppressing the directional information of lagging sounds (echo suppression). Echo suppression is a prerequisite for faithful sound localization in natural environments but can break down depending on the behavioral context. To date, the neural mechanisms that suppress echo directional information without suppressing the perception of echoes themselves are not understood. We performed in vivo recordings in Mongolian gerbils of neurons of the dorsal nucleus of the lateral lemniscus (DNLL), a GABAergic brainstem nucleus that targets the auditory midbrain, and show that these DNLL neurons exhibit inhibition that persists tens of milliseconds beyond the stimulus offset, so-called persistent inhibition (PI). Using in vitro recordings, we demonstrate that PI stems from GABAergic projections from the opposite DNLL. Furthermore, these recordings show that PI is attributable to intrinsic features of this GABAergic innervation. Implementation of these physiological findings into a neuronal model of the auditory brainstem demonstrates that, on a circuit level, PI creates an enhancement of responsiveness to lagging sounds in auditory midbrain cells. Moreover, the model revealed that such response enhancement is a sufficient cue for an ideal observer to identify echoes and to exhibit echo suppression, which agrees closely with the percepts of human subjects.

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“…The envelope processor implements the interaction between excitation from the output of the binaural coincidence detector with delayed inhibition from the same output. Possible anatomical substrates for an ITD-sensitive inhibitory input to the IC, include projections from the dorsal nucleus of the lateral lemniscus (Adams and Mugnaini 1984;Brugge et al 1970) and intrinsic inhibitory connections within the IC (Oliver et al 1994). The envelope processor stage of the model, with the interaction of short excitation with delayed, long-lasting inhibition, is similar to existing models of IC responses to AM acoustic stimuli (Nelson and Carney 2004).…”

Section: Phenomenological Model For Itd Tuningmentioning

confidence: 89%

Sensitivity of Inferior Colliculus Neurons to Interaural Time Differences in the Envelope Versus the Fine Structure With Bilateral Cochlear Implants

Smith¹,

Delgutte²

2008

Journal of Neurophysiology

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Smith ZM, Delgutte B. Sensitivity of inferior colliculus neurons to interaural time differences in the envelope versus the fine structure with bilateral cochlear implants. J Neurophysiol 99: 2390 -2407, 2008. First published February 20, 2008 doi:10.1152/jn.00751.2007. Bilateral cochlear implantation seeks to improve hearing by taking advantage of the binaural processing of the central auditory system. Cochlear implants typically encode sound in each spectral channel by amplitude modulating (AM) a fixed-rate pulse train, thus interaural time differences (ITD) are only delivered in the envelope. We investigated the ITD sensitivity of inferior colliculus (IC) neurons with sinusoidally AM pulse trains. ITD was introduced independently to the AM and/or carrier pulses to measure the relative efficacy of envelope and fine structure for delivering ITD information. We found that many IC cells are sensitive to ITD in both the envelope (ITD env ) and fine structure (ITD fs ) for appropriate modulation frequencies and carrier rates. ITD env sensitivity was generally similar to that seen in normal-hearing animals with AM tones. ITD env tuning generally improved with increasing modulation frequency up to the maximum modulation frequency that elicited a sustained response in a neuron (tested Յ160 Hz). ITD fs sensitivity was present in about half the neurons for 1,000 pulse/s (pps) carriers and was nonexistent at 5,000 pps. The neurons that were sensitive to ITD fs at 1,000 pps were those that showed the best ITD sensitivity to low-rate pulse trains. Overall, the best ITD sensitivity was found for ITD contained in the fine structure of a moderate rate AM pulse train (1,000 pps). These results suggest that the interaural timing of current pulses should be accurately controlled in a bilateral cochlear implant processing strategy that provides salient ITD cues.

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Responses of neurons in the dorsal nucleus of the lateral lemniscus of cat to binaural tonal stimulation.

Cited by 181 publications

References 0 publications

Neural Sensitivity to Periodicity in the Inferior Colliculus: Evidence for the Role of Cochlear Distortions

Neural Sensitivity to Periodicity in the Inferior Colliculus: Evidence for the Role of Cochlear Distortions

Inhibiting the Inhibition: A Neuronal Network for Sound Localization in Reverberant Environments

Sensitivity of Inferior Colliculus Neurons to Interaural Time Differences in the Envelope Versus the Fine Structure With Bilateral Cochlear Implants

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