Responses of selected biomarkers, female reproductive hormones and tissue changes in non-pregnant does challenged with Mannheimia haemolytica serotype A2 and its outer membrane protein (OMP) immunogen

Boorei, Mohamed Abdirahman; Paul, Bura Thlama; Jesse, Faez Firdaus Abdullah; Chung, Eric Lim Teik; Lila, Mohd Azmi Mohd

doi:10.1016/j.micpath.2022.105674

Cited by 1 publication

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“…haemolytica is currently classified into 12 serotypes based on the results of experiments conducted by Angen et al [8]. Serotypes A1, A2, and A6 are the most commonly isolated serotypes worldwide [9], with serotype A2 being the primary pathogen in sheep and goats [10]. M. haemolytica is an acute infectious pathogen that can cause sepsis and tissue hemorrhaging [11].…”

Section: Introductionmentioning

confidence: 99%

Immune Cells in the Spleen of Mice Mediate the Inflammatory Response Induced by Mannheimia haemolytica A2 Serotype

Jiao,

Jiang,

Meng

et al. 2024

Animals

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(1) Background: Mannheimia haemolytica (M. haemolytica) is an opportunistic pathogen and is mainly associated with respiratory diseases in cattle, sheep, and goats. (2) Methods: In this study, a mouse infection model was established using a M. haemolytica strain isolated from goats. Histopathological observations were conducted on various organs of the mice, and bacterial load determination and RNA-seq analysis were specifically performed on the spleens of the mice. (3) Results: The findings of this study suggest that chemokines, potentially present in the spleen of mice following a M. haemolytica challenge, may induce the migration of leukocytes to the spleen and suppress the release of pro-inflammatory factors through a negative feedback regulation mechanism. Additionally, an interesting observation was made regarding the potential of hematopoietic stem/progenitor cells congregating in the spleen to differentiate into immune cells, which could potentially collaborate with leukocytes in their efforts to counteract M. haemolytica invasion. (4) Conclusions: This study revealed the immune regulation mechanism induced by M. haemolytica in the mouse spleen, providing valuable insights into host–pathogen interactions and offering a theoretical basis for the prevention, control, and treatment of mannheimiosis.

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