Responses of sericotropin to toxic and pathogenic challenges: possible role in defense of the wax moth Galleria mellonella

Shaik, Haq Abdul; Mishra, Archana; Sehadová, Hana; Kodrı́k, Dalibor

doi:10.1016/j.cbpc.2019.108633

Cited by 9 publications

(9 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the expression of two AMPs belonging to defensins, i.e., galiomicin and gallerimycin, has been detected in the brains of G. mellonella larvae after injection of Habrobracon hebetor venom or topical application of the entomopathogenic nematode Steinernema carpocapse . However, the role of these peptides in the G. mellonella nervous system has not been investigated yet [ 31 ]. In this study, the upregulation of the sericotropin gene and peptide was also detected in the brains of challenged larvae.…”

Section: Amps In the Nervous Systemmentioning

confidence: 99%

“…It has been demonstrated that synthetic peptides derived from the N- and C-terminal parts of sericotropin exhibited antibacterial activity against Xenorhabdus spp. bacteria, i.e., symbionts of S. carpocapse , suggesting an antimicrobial role of sericotropin expressed in the G. mellonella brain [ 31 ]. In the brains of the honeybee A. meliffera infected with deformed wing virus (DWV), transcriptomic and metabolomic analyses revealed overexpression of genes encoding proline-rich AMPs, abaecin and apidaecin, as well as hymenoptaecin and an increased level of these peptides [ 32 ].…”

Section: Amps In the Nervous Systemmentioning

confidence: 99%

See 1 more Smart Citation

Unraveling the Role of Antimicrobial Peptides in Insects

Stączek

Cytryńska

Zdybicka-Barabas

2023

IJMS

View full text Add to dashboard Cite

Antimicrobial peptides (AMPs) are short, mainly positively charged, amphipathic molecules. AMPs are important effectors of the immune response in insects with a broad spectrum of antibacterial, antifungal, and antiparasitic activity. In addition to these well-known roles, AMPs exhibit many other, often unobvious, functions in the host. They support insects in the elimination of viral infections. AMPs participate in the regulation of brain-controlled processes, e.g., sleep and non-associative learning. By influencing neuronal health, communication, and activity, they can affect the functioning of the insect nervous system. Expansion of the AMP repertoire and loss of their specificity is connected with the aging process and lifespan of insects. Moreover, AMPs take part in maintaining gut homeostasis, regulating the number of endosymbionts as well as reducing the number of foreign microbiota. In turn, the presence of AMPs in insect venom prevents the spread of infection in social insects, where the prey may be a source of pathogens.

show abstract

Section: Amps In the Nervous Systemmentioning

confidence: 99%

Section: Amps In the Nervous Systemmentioning

confidence: 99%

Unraveling the Role of Antimicrobial Peptides in Insects

Stączek

Cytryńska

Zdybicka-Barabas

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Various scientific research has been conducted on the molecular and biochemical aspects of AP to improve the biosynthesis of its active ingredients i.e., andrographolide (AGL) [2]. The strong effects of AGL alike toxins, insecticides interfering with molting hormone pools-controlled insect pests thereby saving food crops with global economic benefit [3][4][5]. A decade of proliferating scientific research with AGL based on the active components established its multifarious pharmacological effect as an anti-bacterial, anti-viral, and anti-inflammation [6,7].…”

Section: Introductionmentioning

confidence: 99%

Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health

et al. 2021

Self Cite

View full text Add to dashboard Cite

Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C20H30O5) isolated from Andrographis paniculate (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.

show abstract

“…In recent years, invertebrate experimental animals have been used to study bacterial infection and host interactions (Shaik, Mishra, Sehadová, & Kodrík, 2020;Lapointe, McCarthy, Dunphy, & Mandato, 2020). In addition, invertebrate infection models are frequently used in the fields of medicine, pharmacy and veterinary medicine (Matsumoto, Ishii, Shimizu, Kawamoto, & Sekimizu, 2017;Ishii, Matsumoto, Yamada, Abe, & Sekimizu, 2017;Singulani, Scorzoni, De Oliveira, Marcos, & Assato, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, invertebrate infection models are frequently used in the fields of medicine, pharmacy and veterinary medicine (Matsumoto, Ishii, Shimizu, Kawamoto, & Sekimizu, 2017;Ishii, Matsumoto, Yamada, Abe, & Sekimizu, 2017;Singulani, Scorzoni, De Oliveira, Marcos, & Assato, 2018). In particular, Galleria mellonella (Lepidoptera: Pyralidae) larvae have been used as model organisms in many studies on bacterial pathogenicity or the efficacy of antibiotic treatments (Rossoni et al, 2017;Shaik et al, 2020;Lapointe, McCarthy, Dunphy, & Mandato, 2020). The large surface area of G. mellonella larvae and the easy isolation of hemolymph provide advantages for physiological and biochemical studies (Andrejko, Zdybicka-Barabas, & Cytryńska, 2014;Tsai, Loh, & Proft, 2016).…”

Section: Introductionmentioning

confidence: 99%

Physiological and Biochemical Effects of Klebsiella oxytoca Infection on Model Organism Galleria mellonella L.

Sugeçti

Çelik²,

Büyükgüzel³

et al. 2021

jers

View full text Add to dashboard Cite

In this study, the physiological and biochemical response of model insect Galleria mellonella due to Klebsiella oxytoca infection was investigated. Changes in metabolic enzyme activities such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), amylase (AMYL) and gamma glutamyl transferase (GGT) occurred due to K. oxytoca infection. In addition, amounts of non-enzymatic antioxidant such as uric acid (UA), bilirubin (BIL) and albumin (ALB) were altered in G. mellonella hemolymph due to infection. The results obtained from this study showed that G. mellonella can be used as a model organism in the evaluation of the physiological effects of K. oxytoca infection on the host.

show abstract

Responses of sericotropin to toxic and pathogenic challenges: possible role in defense of the wax moth Galleria mellonella

Cited by 9 publications

References 61 publications

Unraveling the Role of Antimicrobial Peptides in Insects

Unraveling the Role of Antimicrobial Peptides in Insects

Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health

Physiological and Biochemical Effects of Klebsiella oxytoca Infection on Model Organism Galleria mellonella L.

Contact Info

Product

Resources

About