Responses of sex steroid hormones to different intensities of exercise in endurance athletes

Abstract

New Findings r What is the central question of this study?What is the effect of different exercise intensities on sex steroid hormone concentrations in individuals with different degrees of physical fitness? r What is the main finding and its importance?In endurance athletes, serum concentrations of sex steroid hormones increased only with high-intensity exercise. Moreover, different responses of sex steroid hormone secretions were induced by different exercise intensities in individuals with low and high levels of physical fitness.Previous studies have shown that acute exercise elevates sex steroid hormone concentrations in rodents and that sprint exercise increases circulating testosterone in healthy young men. However, the effect of different exercise intensities on sex steroid hormone responses at different levels of physical fitness is still unclear. In this study, we compared circulating sex steroid hormone responses at different exercise intensities in athletes and non-athletes. Eight male endurance athletes and 11 non-athletes performed two 15 min sessions of submaximal exercise at 40 and 70% peak oxygen uptake (V O 2 peak ), respectively, and exercised at 90%V O 2 peak until exhaustion. Venous blood samples were collected during the last minute of each submaximal exercise session and immediately after exhaustion. Acute exercise at 40, 70 and 90%V O 2 peak induced significant increases in serum dehydroepiandrosterone (DHEA) and free testosterone concentrations in non-athletes. On the contrary, only 90%V O 2 peak exercise led to an increase in serum DHEA and free testosterone concentrations in athletes. Serum 5α-dihydrotestosterone concentrations increased with 90%V O 2 peak exercise in both athletes and non-athletes. Additionally, serum estradiol concentrations were significantly increased at moderate and high exercise intensities in both athletes and non-athletes. These results indicate that in endurance athletes, serum sex steroid hormone concentrations, especially serum DHEA and 5α-dihydrotestosterone concentrations, increased only with high-intensity exercise, suggesting that different responses of sex steroid hormone secretion are induced by different exercise intensities in individuals with low and high levels of physical fitness. In athletes, therefore, high-intensity exercise may be required to increase circulating sex steroid hormone concentrations.

Energy Constraint as a Novel Mechanism Linking Exercise and Health

“…Men also show an inverse relationship between reproductive investment and physical activity. As with inflammation and HPA activity, testosterone levels rise during exercise, but endurance athletes exhibit lower baseline levels and a blunted exercise-induced rise (29,31,72). Morning salivary testosterone is also lower among men in physically active non-industrial populations compared with those in less active, industrialized countries (21).…”

“…The suppressive effects of exercise are often attributed to "energy stress" or inadequate intake (24,27,35,49,72,76). But with the superabundance of food energy in modern industrialized populations, it is unclear why increased physical activity should result in energy stress, unless TEE is constrained.…”

Vigorous Physical Activity is Associated with Regular Aerobic Exercise-Induced Increased Serum Testosterone Levels in Overweight/Obese Men

“…Several studies have reported that acute aerobic exercise increases circulating testosterone levels in men [20][21][22][23][24]. Therefore, it is possible that regular aerobic exercise increases circulating testosterone levels.…”

Acute responses of comprehensive gonadosteroids and corticosteroids to resistance exercise before and after 10 weeks of supervised strength training

“…Further evidence that acute exercise may modify the assumed gonadosteroid conversion pathway (i.e. DHEA‒androstenedione‒testosterone‒5α‐dihydrotestosterone) was observed by Sato and colleagues (). In their study, low‐intensity endurance exercise increased DHEA and free testosterone concentrations in untrained subjects, but 5α‐dihydrotestosterone increased only during high‐intensity endurance exercise.…”