Responses of Skeletal Muscle Hypertrophy in Wistar Rats to Different Resistance Exercise Models

Luciano, Thais F.; Marques, Scherolin O.; Pieri, Bruno Luiz da Silva; Souza, Daniela R.; Araújo, Luciano Vieira de; Nesi, Renata Tiscoski; Scheffer, Débora da Luz; Comin, Vitor Hugo; Pinho, Ricardo A.; Muller, A P; Souza, Cláudio Teodoro de

doi:10.33549/physiolres.933256

Cited by 25 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The muscles included in the selected articles were quadriceps femoris (Luciano et al, 2017; Neves et al, 2019), soleus (Cassilhas et al., 2013; Deschenes et al., 1994, 2000, 2015; Grans et al., 2014; Krause Neto & Gama, 2017; Padilha et al, 2017; Padilha et al., 2019; Prestes et al, 2012; Ribeiro et al, 2017; Shamsi et al, 2013), tibialis anterior [TA] (Jung et al., 2015; Lee et al, 2016; Neves et al, 2019; Prestes et al, 2012), gastrocnemius (Cassilhas et al., 2013; Grans et al., 2014; Lee et al, 2016; Ribeiro et al, 2017; Souza et al., 2014; Tibana et al, 2017), plantaris (Cassilhas et al., 2013; Deschenes et al., 2015; Mônico‐Neto et al, 2015; Padilha et al., 2019), FHL (Chi, Hou, Wu, Wang, & Yu, 2020; Gil & Kim, 2015; Hornberger & Farrar, 2004; Lee et al, 2016, 2018; Lee & Farrar, 2003; Padilha et al., 2019; Shamsi et al, 2014), extensor digitorum longus [EDL] (Deschenes et al., 1994; Krause Neto & Gama, 2017; Lim et al, 2018), flexor digitorum profundus [FDP] (Chi et al., 2020; Kwon et al, 2018), flexor digitorum longus [FDL] (Cassilhas et al., 2013), tríceps brachialis (Nascimento et al., 2013) and bíceps brachialis (Souza et al., 2014).…”

Section: Resultsmentioning

confidence: 99%

“…According to Tibana et al (2017), despite no increased muscle mass, LRT is efficient in inducing a significant increase in the mean muscle fibers cross‐sectional area (fCSA) and the capacity of the rodent to carry the load. Yet, other studies corroborate these conclusions, demonstrating that LRT might stimulate hypertrophy of several different types of muscles (Jung et al., 2015; Know, Jang, Cho, Jang, & Lee, 2017; Lim, Gil, Quan, Viet, & Kim, 2018; Luciano et al, 2017; Ribeiro et al, 2017).…”

Section: Introductionmentioning

confidence: 85%

“…Such controversy was generated from the apparent differences found between the equipment used for the training of rodents and humans. However, since the ladder‐based resistance training model (LRT) proposed by Hornberger and Farrar (2004), a large amount of evidence has emerged, and greater control of training variables has been investigated and better controlled in experimental resistance training (Krause Neto et al., 2016, 2018; Luciano et al, 2017; Tibana et al, 2017). Despite this, there is still some doubt as to the efficiency of this training model in stimulating muscle hypertrophy of different muscle types in young and adult rats (Hornberger & Farrar, 2004; Son et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Muscle hypertrophy and ladder‐based resistance training for rodents: A systematic review and meta‐analysis

et al. 2020

View full text Add to dashboard Cite

This study aimed to review the effects of ladder‐based resistance training (LRT) on muscle hypertrophy and strength in rodents through a systematic review with meta‐analysis. We systematically searched PubMed/Medline, SportDiscuss, Scopus, Google Scholar, Science Direct, and Scielo database on May 18, 2020. Thirty‐four studies were included measuring total (mCSA) or mean muscle fibers cross‐sectional area (fCSA) or maximum load‐carrying capacity (MLCC) or muscle mass (MM). About the main results, LRT provides sufficient mechanical stimulation to increase mCSA and fCSA. Meta‐analysis showed a significant overall effect on the fCSA (SMD 1.89, 95% CI [1.18, 2.61], p < .00001, I2 = 85%); however, subgroup analysis showed that some muscle types might not be hypertrophied through the LRT. Meta‐analysis showed a significant training effect on the MM (SMD 0.92, 95% CI [0.52, 1.32], p < .00001, I2 = 72%). Sub‐group analysis revealed that soleus (SMD 1.32, 95% CI [0.11, 2.54], p = .03, I2 = 86%) and FHL (SMD 1.92, 95% CI [1.00, 2.85], p < .0001, I2 = 71%) presented significant training effects, despite moderate heterogeneity levels (I2 = 72%). MLCC increases considerably after a period of LRT, regardless of its duration and the characteristics of the protocols (SMD 12.37, 95% CI [9.36, 15.37], p < .00001, I2 = 90%). Through these results, we reach the following conclusions: (a) LRT is efficient to induce muscle hypertrophy, although this effect varies between different types of skeletal muscles, and; (b) the ability of rodents to carry load increases regardless of the type and duration of the protocol used.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Muscle hypertrophy and ladder‐based resistance training for rodents: A systematic review and meta‐analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Few studies have examined the effects of exercise on Sestrin levels. Luciano and colleagues reported that 12 weeks of resistance training increased Sesn2 protein content in the quadriceps of normal rats (Luciano et al, 2017). Regular exercise increased Sesn2 and Sesn3 expression in lean and obese mice (Liu et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice

Lenhare

Crisol

Silva

et al. 2017

Experimental Gerontology

View full text Add to dashboard Cite

Sestrins and autophagy deficiencies are associated with several aging-related organic dysfunctions and metabolic disorders. Here we evaluate the effects of acute exercise on Sestrin 2 (Sesn2) protein content and autophagy markers in the skeletal muscle of experimental models of aging. Twenty-four months-old C57BL/6J male mice were submitted to a single bout of swimming exercise and the gastrocnemius muscle was evaluated by Western blot. Transcriptomic and phenotypic analysis were also performed by using strains of genetically-diverse BXD mice. The bioinformatics analysis showed a negative correlation between Sesn2 mRNA levels in the skeletal muscle and body weight gain, plasma triglycerides and fasting glucose and positive correlation with several autophagic markers in the muscle of BXD mice. Consistent with these findings, low levels of Sesn2 protein content were observed in the gastrocnemius muscle of C57BL/6J old mice when compared to young group. Interestingly, the acute aerobic exercise induced Sesn2 accumulation and modulated several markers of autophagy in the gastrocnemius muscle old mice, including unc-51-like kinase-1 (Ulk1) phosphorylation and the protein levels of Atg5, Atg7, p62 and LC3-II. Finally, exercise increased insulin sensitivity in old animals, as demonstrated by kITT. Taken together, these findings demonstrated the acutely, aerobic physical exercise recovers Sestrin 2 protein content and induces autophagy in the skeletal muscle of old mice, contributing with the improvement of insulin sensitivity an aging animal model.

show abstract

“…Resistance training promotes micro-injuries in skeletal muscle, with alterations in the cytoskeleton, loss of sarcomeres and structural proteins, and necrosis of muscle fibers, among others (Damas et al, 2018). These changes may be caused by the mechanical stress induced by the training or activation of the calcium degradation pathway and the inflammatory response (Brook et al, 2016;Luciano et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Adaptations of Muscle Tissue of Rats Submitted to Aerobic and Anaerobic Physical Training in Different Ergometer Models

et al. 2018

View full text Add to dashboard Cite

The objective of the present study was to analyze the effects of four different training models, two aerobic and two anaerobic models, in relation to muscular hypertrophy, by means of morphometric analysis of the muscle cells of the soleus muscle and the extensor digitorum longus muscle (EDL). The animals were divided into five groups, control (C), aerobic training in swimming (ATS), resistance training in water (RTW), aerobic training on a treadmill (ATT), and resistance training in climbing (RTC). The aerobic training was performed at 70 % of the anaerobic threshold for 30 minutes, while the RTW was composed of 3 series of 10 jumps, and the RTC 4 series of climbs, both at 80 % of the maximum load. All training protocols were performed for a total period of 4 weeks, 3 times per week. The diameters of the muscle cells were measured by means of histological slides of the EDL and soleus muscles. For the EDL muscle, there was no difference between the ATS and ATT aerobic training models (p = 0.20). However, the RTW presented greater hypertrophy when compared to the RTC (p <0.01). Regarding the soleus muscle, the ATS was responsible for generating greater hypertrophy than the ATT (p <0.01). In addition, the RTC was more efficient at producing hypertrophy than the RTW (p <0.01). In this way, it was concluded that exercise adaptation was according to exercise type, aerobic or anaerobic, and not to the modality used.

show abstract

Responses of Skeletal Muscle Hypertrophy in Wistar Rats to Different Resistance Exercise Models

Cited by 25 publications

References 22 publications

Muscle hypertrophy and ladder‐based resistance training for rodents: A systematic review and meta‐analysis

Muscle hypertrophy and ladder‐based resistance training for rodents: A systematic review and meta‐analysis

Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice

Adaptations of Muscle Tissue of Rats Submitted to Aerobic and Anaerobic Physical Training in Different Ergometer Models

Contact Info

Product

Resources

About