Responses of testosterone hormone and important inflammatory cytokines in bucks after challenge with Mannheimia haemolytica A2 and its LPS endotoxin

Azhar, Nur Amira; Paul, Bura Thlama; Jesse, Faez Firdaus Abdullah; Chung, Eric Lim Teik; Isa, Kamarulrizal Mat; Lila, Mohd Azmi Mohd; Haron, Abd Wahid

doi:10.1007/s11250-021-02683-6

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…Similarly, Umer et al (2020) described the findings in bucks infected with Corynebacterium pseudotuberculosis showed irregular shrinkage of lumen, oedema, degeneration and necrosis of spermatogonia cells within seminiferous tubules as well as sloughing, degeneration and germinal epithelium necrosis. A recent study conducted by Azhar et al (2021) on bucks challenged with M. haemolytica serotype A2 and its lipopolysaccharide (LPS) endotoxin indicated that infection of M. haemolytica A2 and its LPS potentially disrupt normal pathophysiological responses which would alter the reproductive functions of bucks. This, in turn, leads to reproductive inefficiency in infected animals.…”

Section: Negative Effects Of Bacterial Infection On Male Reproductive...mentioning

confidence: 99%

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

2023

Int J Vet Sci

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Pneumonia is the inflammation of lung parenchyma due to various organisms resulting in numerous manifestations and sequelae. The environment in the tropical regions provides optimal conditions for infection to occur in small ruminants. Mannheimiosis caused by Mannheimia haemolytica is the most frequent isolated bacteria causing pneumonia in small ruminants. The bacteria may cause an acute infection which can lead to death without proper diagnosis and treatment. To date, there are still scarce study on the effect of anti-microbial and anti-inflammatory treatments on reproductive physiology that warrants investigation. Hence, this review paper aims to focus on the possible effect of a combined usage of anti-microbial and anti-inflammatory treatments toward male reproductive physiology.

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Section: Negative Effects Of Bacterial Infection On Male Reproductive...mentioning

confidence: 99%

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

2023

Int J Vet Sci

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“…The pathological manifestations of mastitis caused by M. haemolytica include ecchymosis and ecchymotic bleeding, accompanied by neutrophil infiltration and, in advanced stages, congestion, hemorrhage, venous thrombosis, and mammary parenchymal necrosis; the mammary ducts are full of fibrin, milk clots, and inflammatory exudates [17]. The reproductive system function can be influenced in animals following infection with M. haemolytica, as indicated by several studies [18,19].…”

Section: Introductionmentioning

confidence: 99%

Immune Cells in the Spleen of Mice Mediate the Inflammatory Response Induced by Mannheimia haemolytica A2 Serotype

Jiao,

Jiang,

Meng

et al. 2024

Animals

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(1) Background: Mannheimia haemolytica (M. haemolytica) is an opportunistic pathogen and is mainly associated with respiratory diseases in cattle, sheep, and goats. (2) Methods: In this study, a mouse infection model was established using a M. haemolytica strain isolated from goats. Histopathological observations were conducted on various organs of the mice, and bacterial load determination and RNA-seq analysis were specifically performed on the spleens of the mice. (3) Results: The findings of this study suggest that chemokines, potentially present in the spleen of mice following a M. haemolytica challenge, may induce the migration of leukocytes to the spleen and suppress the release of pro-inflammatory factors through a negative feedback regulation mechanism. Additionally, an interesting observation was made regarding the potential of hematopoietic stem/progenitor cells congregating in the spleen to differentiate into immune cells, which could potentially collaborate with leukocytes in their efforts to counteract M. haemolytica invasion. (4) Conclusions: This study revealed the immune regulation mechanism induced by M. haemolytica in the mouse spleen, providing valuable insights into host–pathogen interactions and offering a theoretical basis for the prevention, control, and treatment of mannheimiosis.

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Changes in selected cytokines, acute-phase proteins, gonadal hormones and reproductive organs of non-pregnant does challenged with Mannheimia haemolytica serotype A2 and its LPS endotoxin

Kamarulrizal

Chung

Jesse

et al. 2022

Trop Anim Health Prod

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Responses of testosterone hormone and important inflammatory cytokines in bucks after challenge with Mannheimia haemolytica A2 and its LPS endotoxin

Cited by 7 publications

References 33 publications

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

Immune Cells in the Spleen of Mice Mediate the Inflammatory Response Induced by Mannheimia haemolytica A2 Serotype

Changes in selected cytokines, acute-phase proteins, gonadal hormones and reproductive organs of non-pregnant does challenged with Mannheimia haemolytica serotype A2 and its LPS endotoxin

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