Responses of testosterone hormone concentration, semen quality, and its related pro-inflammatory cytokines in bucks following Corynebacterium pseudotuberculosis and its mycolic acid infection

Faeza, N. M. N.; Jesse, F. F. A.; Hambali, Idris Umar; Odhah, Mohammed Naji; Umer, Muhammad; Wessam, M. M. S.; Mohd-Azmi, M. L.; Wahid, A. H.

doi:10.1007/s11250-019-01878-2

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…High glucocorticoid levels decrease the production and secretion of testosterone from the Leydig cells and spermatogenesis (Brownlee et al, 2005), a process of division and differentiation of germ cells into spermatozoa (Johnson et al, 2000). Any change in this process has a negative effect on the semen quality such as sperm count, percentage of motile sperm, and percentage of morphologically normal sperm, which is observed in the Rottweiler breed (Janevic et al, 2014;Faeza et al, 2019). The low percentage of normal sperm morphology exhibited by the Rottweiler breed is possibly due to the malfunction of the epididymis because of the influence of stressors (Almeida et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Preliminary analysis of reproductive, behavioral and physiological characteristics of military working dogs

et al. 2022

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The use of dogs in military work environments has always aroused great interest in the general population and determining the stress levels they go through is extremely important to maintain their welfare. The aim of this research was to evaluate if the work shifts in military working dogs leads to stress conditions and if this working influences on the reproductive performance and life quality. The study was conducted at the Military Police Kennel located at Campinas, Sao Paulo, Brazil. Eight male dogs of four different breeds (German Shepherd, Belgian Malinois Shepherd, Doberman, and Rottweiler) were evaluated during two different shifts: Working Shifts: animals working 12 hours a day with 2 hour-interval; and Control Shifts: animals that were on their day off (36 hours). Saliva samples were collected for cortisol analysis at the control and working shifts. The study was carried out over 60 days and analyzed behavior, physiology, and reproduction quality. Saliva samples, behavior observation of stereotyping, resting and moving activities and semen analysis were collected by digital stimulation (for combined second and third fractions). The salivary cortisol levels during the control and working shifts were between 0.361-0.438 and 0.312-0.592 µg/dL, respectively; the highest values were found at the end of working shifts. The animals were resting during most of the observation period, but few showed stereotypic behaviors. The testicular consistency was firm and semen parameters were within the normal values in German Shepherd, Belgian Malinois Shepherd, and Doberman dogs. However, Rottweiler dogs had a higher rate of sperm abnormalities, higher salivary cortisol levels, and more stereotypic behaviors. Nevertheless this work highlights the importance of further research relating reproduction and cortisol levels in military dogs.

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Section: Discussionmentioning

confidence: 99%

Preliminary analysis of reproductive, behavioral and physiological characteristics of military working dogs

et al. 2022

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“…La inoculación de extractos de ácidos corynomicólicos, en cabras hembras, causó hemorragia, congestión, degeneración, necrosis, edema e infiltraciones leucocíticas en órganos reproductores y en ganglios linfáticos asociados, así como aumentó la concentración de hormonas estrogénicas (62) . También se han asociado con disminución de testosterona y pérdida de calidad del semen, con aumento en producción de citocinas pro-inflamatorias (5) .…”

Section: Patogénesis Y Mecanismos De Evasión Del Sistema Inmuneunclassified

“…El agente etiológico de la enfermedad, Corynebacterium pseudotuberculosis biovar ovis, causa una infección crónica que se caracteriza por la formación de abscesos en nódulos linfáticos cutáneos o viscerales. Esta enfermedad provoca el deterioro en las condiciones físicas de los animales, disminución de la producción de lana (2) , carne (3) y leche (4) , así como desórdenes reproductivos (5) . En Australia el análisis de tres granjas de la región Occidental, para un total de 600 animales evaluados, permitió establecer que la infección por C. pseudotuberculosis produjo la disminución en la producción de lana grasa en 3.8-4.8 % y de lana limpia en 4.1-6.6 %.…”

Section: Introductionunclassified

Linfadenitis caseosa: factores de virulencia, patogénesis y vacunas. Revisión

Domínguez

Jiménez

Guerrero

2022

Rev. Mex. Cienc. Pecu.

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La linfadenitis caseosa es una enfermedad que afecta la producción ovina y caprina a nivel mundial. El agente etiológico es una bacteria Gram positiva, intracelular facultativa denominada Corynebacterium pseudotuberculosis biovar ovis. La enfermedad puede cursar con un desarrollo cutáneo o visceral, provocando deterioro en la condición física del animal, así como pérdidas en la producción de leche y carne, decomiso de las canales, rechazo de las pieles y como consecuencia, grandes pérdidas económicas. El estudio de los factores de virulencia y los mecanismos de patogénesis han permitido comprender esta enfermedad, así como establecer las moléculas diana para el desarrollo de nuevas vacunas. Existen vacunas comerciales disponibles a nivel mundial; sin embargo, la protección conferida por éstas no ha sido eficaz en el control de la enfermedad. Actualmente el uso de nuevas tecnologías ha permitido la obtención y caracterización de proteínas con potencial inmunogénico para el desarrollado de nuevas vacunas, las cuales podrían ser una alternativa para incrementar la protección. En el presente trabajo se exponen los principales factores de virulencia de Corynebacterium pseudotuberculosis, sus implicaciones en la patogénesis y las tendencias actuales en las formulaciones vacunales.

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“…Several studies have been conducted to understand the immune response of sheep and goat with caseous lymphadenitis, yet the understanding with respect to the immunity is still vague. Nonetheless, the humoral immunity has been recently reported to be highly essential during CLA in sheep and goats (Baird & Fontaine, 2007;Odhah et al, 2017;Faeza et al, 2019a).…”

Section: Introductionmentioning

confidence: 99%

Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract

Odhah¹,

Jesse²,

Paul³

et al. 2023

JAHP

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Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in small ruminants and is of considerable economic importance in many countries worldwide. The control of the disease in animals depends on the control of the disease in infected animals. Nevertheless, few countries where the disease was previously endemic have successfully eradicated the pathogen. This investigation was undertaken to determine the antibody titre (IgM and IgG) in does challenged with C. pseudotuberculosis and its Mycolic acids (MAs) immunogen extract. About 12 healthy crossbred female Boer goats were assigned into three groups (A, B and C), each comprising of 4 goats. Group A (Negative control group) was inoculated intradermally with 2 ml of sterile phosphate-buffered saline (PBS-pH 7); Group B (Mycolic acid group) was inoculated intradermally with 2 ml of immunogenic Mycolic acid extract (1g /ml); while group C (Positive control group) was inoculated intradermally with 2 ml of 10 9 colony-forming unit of live C. pseudotuberculosis. All the animals were observed for 90 days post-inoculation. Blood samples were collected via the jugular vein from all the groups before the inoculation and once weekly after the challenge until the end of the research period. The result of the study showed that the Immunoglobulin M (IgM) concentration in goats inoculated with C. pseudotuberculosis significantly (p<0.05) increased at week 2 (18.97±0.28 ng/ml), week 3 (33.97±0.59 ng/ml), week 4 (31.94±0.28 ng/ml) and week 5 (12.51±2.42). Whereas, in the mycolic acid group, the IgG antibody titre increased consistently from week 1 to week 3 (20.99±1.96 ng/ml; 15.52±3.78 ng/ml; 14.74±0.34 ng/ml) respectively. On the other hand, the Immunoglobulin G (IgG) concentration was found to significantly increase (p<0.05) after treatments and the increase persisted up till week 11 post-inoculation. The concentration of IgG steadily increased in C. pseudotuberculosis and MAs-treated groups, reaching the peak at week 9 (32.82±8.56 ng/ml) in C. pseudotuberculosis group and week 10 (28.41±1.27 ng/ml) in MAs group, then declined slowly from week 10 till week 12. In conclusion, there was an elevated level in the IgM and IgG antibodies post-infection with C. pseudotuberculosis and MAs. However, while the IgG antibody levels started declining at week 9 for C. pseudotuberculosis, the MAs group was sustained until week ten before reducing. Therefore, MAs can be used as an immunogen to control caseous lymphadenitis infection caused by C. pseudotuberculosis among small ruminants.

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Responses of testosterone hormone concentration, semen quality, and its related pro-inflammatory cytokines in bucks following Corynebacterium pseudotuberculosis and its mycolic acid infection

Cited by 4 publications

References 21 publications

Preliminary analysis of reproductive, behavioral and physiological characteristics of military working dogs

Preliminary analysis of reproductive, behavioral and physiological characteristics of military working dogs

Linfadenitis caseosa: factores de virulencia, patogénesis y vacunas. Revisión

Immune Responses of Goats to Corynebacterium pseudotuberculosis and its Mycolic Acids (MAs) Extract

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