Responses of the intestinal microbiota to exposure of okadaic acid in marine medaka Oryzias melastigma

Yang, Yongmeng; Li, Aifeng; Qiu, Jiangbing; Gao, Dongmei; Yin, Chao; Li, Dongyue; Yan, Wenhui; Dang, Hui; Li, Peiyao; Wu, Ruolin; Han, Lilin; Wang, Xiaoyun

doi:10.1016/j.jhazmat.2023.133087

Cited by 6 publications

(2 citation statements)

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“…Standardizing methodologies for microbiome analysis, addressing interindividual variability, and establishing causal relationships between microbial signatures and colorectal cancer outcomes are critical steps. Additionally, considering the dynamic nature of the gut microbiome, longitudinal studies are essential for capturing temporal changes and understanding the impact of interventions on microbial communities. , …”

Section: Molecular Profiling Of Colorectal Cancermentioning

confidence: 99%

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Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Section: Molecular Profiling Of Colorectal Cancermentioning

confidence: 99%

“…Additionally, considering the dynamic nature of the gut microbiome, longitudinal studies are essential for capturing temporal changes and understanding the impact of interventions on microbial communities. 96,97…”

Section: Phosphoproteomics and Protein Interaction Networkmentioning

confidence: 99%