Responses of the Ocular Anterior Segment and Refraction to 0.5% Tropicamide in Chinese School-Aged Children of Myopia, Emmetropia, and Hyperopia

Yuan, Ying; Zhang, Zhengwei; Zhu, Jianfeng; He, Xiangui; Du, Ergang; Jiang, Kelimu; Zheng, Wenjing; Ke, Bilian

doi:10.1155/2015/612728

Cited by 22 publications

(19 citation statements)

References 24 publications

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“…Cycloplegic agents cause paralysis of the ciliary muscle, pupillary dilation and eliminates accommodation. During accommodation, the LT and anterior lens curvature changes, which would lead to a change in anterior segment structure . When accommodation is inhibited, the lens becomes flatter and moves posteriorly.…”

Section: Discussionmentioning

confidence: 99%

The effect of cycloplegia on biometric measurements using swept‐source optical coherence tomography‐based biometry

Özçalışkan

Yenerel

2019

Clinical and Experimental Optometry

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Background: To evaluate the effect of pupil dilation obtained with cyclopentolate on biometric measurements using swept-source optical coherence tomography biometry. Methods: This study involved 63 eyes of 63 healthy volunteers. After ophthalmic examination, biometry measurements of the participants were obtained with IOL Master 700 (Carl Zeiss Meditec AG, Jena, Germany). After pre-dilation measurements were taken, subjects were given one drop of cyclopentolate hydrochloride ophthalmic solution three times at 10-minute intervals. When cycloplegia had been achieved, a dilated fundus examination was conducted and post-dilation measurements were taken with IOL Master 700. The biometric parameters were recorded and SPSS Software 22.0 was used for statistical analysis. Results: There was a significant increase in anterior chamber depth, anterior aqueous depth and central corneal thickness values after pupil dilation (p < 0.05). A significant decrease was observed in lens thickness values after cycloplegia (p < 0.05). There were no statistically significant differences between pre-dilation and post-dilation axial length, keratometry (K1, K2) and white-to-white values (p > 0.05). Conclusion: This study demonstrated there is no significant difference in axial length and keratometry measurements using swept-source optical coherence tomography biometry before and after cycloplegia.

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Section: Discussionmentioning

confidence: 99%

The effect of cycloplegia on biometric measurements using swept‐source optical coherence tomography‐based biometry

Özçalışkan

Yenerel

2019

Clinical and Experimental Optometry

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“…Post-cycloplegia examination was performed 30 min after administering 5 cycles (each cycle 5 min apart) of 0.5% tropicamide, which is in agreement with previous research [11]. To maintain accuracy, all examinations were done three times by the same ophthalmologist.…”

Section: Examination Proceduresmentioning

confidence: 62%

“…Evidence has shown that anterior chamber changes occur along with axial length growth in myopic children's eyes [6][7][8]. But cycloplegics, agents for paralyzing the ciliary muscle, have been reported to induce changes in the anterior segment and crystalline lens to overcome the myopic shift [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Tropicamide on crystalline Lens rise in low-to-moderate myopic eyes

Chen

et al. 2020

BMC Ophthalmol

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Background: Cycloplegics have been reported to induce changes in the lens thickness. However, the studies of correlation between cycloplegia and the lens position are limited. This study aims to investigate changes in crystalline lens rise (CLR) and other anterior segment parameters after inducing cycloplegia with tropicamide. Methods: In this consecutive case study, 39 children (20 boys and 19 girls; mean age, 9.51 ± 1.75 years, mean spherical equivalence [SE], − 1.9 ± 1.5 D) with low-to moderate myopia were examined using CASIA 2 both before and after 30 min of administering 5-cycles (each 5 min apart) of 0.5% tropicamide. Measurements included CLR, crystalline lens thickness (CLT), mean radius of curvature of the anterior/posterior surface of the lens (Rf_ave/Rb_ ave), anterior chamber depth (ACD), anterior chamber width (ACW), and central corneal thickness (CCT). Correlations of CLT and CLR with ACD, SE, and age were assessed respectively. Results: CLT and CLR decreased significantly after cycloplegia (p < 0.001 and p < 0.001, respectively); whereas CCT, ACD, and Rf_ave increased (p = 0.008, p < 0.001, p < 0.001, respectively). A positive correlation was found between CLR and SE (r = 0.565, p < 0.001). However, a negative correlation between ACD and CLR was found before and after cycloplegia (r = − 0.430, p = 0.006; r = − 0.342, p = 0.035, respectively). Conclusions: The crystalline lens appeared thinner and moved backward after cycloplegia. ACD increased mainly due to the backward movement of the crystalline lens. These results aid in elucidating the impact of crystalline lens changes during the process of accommodation.

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“…Since the ciliary muscle relaxes with cycloplegia, the lens thickness and therefore the anterior chamber biometric values also change. This alteration is most marked in hypermetropes and least apparent in myopes [ 19 ]. If further studies find that the lens thickness and the increase in ACD after cycloplegia in a non-accommodative state in RAE patients is higher than that of hypermetropic patients, it would further strengthen our findings.…”

Section: Discussionmentioning

confidence: 99%

Anterior Segment Changes during Accommodation in Accommodative Esotropia

Koç

Yaşar

Uzel

et al. 2018

Korean J Ophthalmol

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PurposeTo evaluate the anterior segment biometric parameters of non-accommodative and accommodative refractive accommodative esotropia (RAE).MethodsEighty-one eyes of 81 patients were included in this prospective, case-control study. The patients were divided into three groups as follows: the RAE group (n = 31), the hypermetropia group (n = 25), and the emmetropia group (n = 25). Measurements were obtained in the non-accommodative (0.0 diopters) and accommodative status (-5.0 diopters) using a Pentacam HR. The anterior chamber depth (ACD), anterior chamber volume (ACV), pupil diameter (PD), and anterior chamber angle (ACA) were evaluated at all four quadrants.ResultsThe ACD, ACV and PD values in the RAE group were lower than those of the other groups in both states (p < 0.05). The ACD values were lower in the hypermetropia group than in the emmetropia group for the non-accommodative status (p = 0.024) but were similar for the accommodative status (p = 0.225). PD and ACV values were lower in the hypermetropia group than in the emmetropia group in both states (non-accommodative status, p = 0.011 and p = 0.022; accommodative status, p = 0.026 and p = 0.034, respectively). Changes in ACD, ACV and PD during accommodation (Δ) were not significant in the RAE group but were significant for the other groups (hypermetropia: ΔACD, p = 0.001; ΔACV, p = 0.001; ΔPD, p = 0.002; emmetropia: ΔACD, p < 0.001; ΔACV, p = 0.001; ΔPD, p < 0.001). These changes were significantly lower in the hypermetropia group than in the emmetropia group (ΔACD, p = 0.012; ΔACV, p = 0.031; ΔPD, p = 0.034).ConclusionsThe anterior chamber in RAE patients was shallower and the increase in convexity of the anterior surface or forward movement of the crystalline lens was more limited during accommodation in RAE.

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Responses of the Ocular Anterior Segment and Refraction to 0.5% Tropicamide in Chinese School-Aged Children of Myopia, Emmetropia, and Hyperopia

Cited by 22 publications

References 24 publications

The effect of cycloplegia on biometric measurements using swept‐source optical coherence tomography‐based biometry

The effect of cycloplegia on biometric measurements using swept‐source optical coherence tomography‐based biometry

Effect of Tropicamide on crystalline Lens rise in low-to-moderate myopic eyes

Anterior Segment Changes during Accommodation in Accommodative Esotropia

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