Responses to divergent selection for plasma concentrations of insulin-like growth factor-1 in mice

Ht, Blair; McCutcheon, S. N.; Mackenzie, D. D. S.; Gluckman, Peter D.; Ormsby, J. E.; Brier, B. H.

doi:10.1017/s0016672300028159

Cited by 30 publications

(15 citation statements)

References 19 publications

(17 reference statements)

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“…The lack of GH also results in reduced levels of its intermediate effector, insulin-like growth factor I (IGF-I). IGF-I has been associated with increased weight gain in the lines used here (McKnight & Goddard, 1989), in other mouse lines (Blair et al 1989(Blair et al . 1990) and in other species such as sheep (Blair et al 1990).…”

Section: Introductionmentioning

confidence: 89%

The role of growth hormone in lines of mice divergently selected on body weight

Hastings¹,

Bootland²,

Hill³

1993

Genet. Res.

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An understanding of the physiological and genetic changes which determine the response to selection is critical for both evolutionary theory and to assess the application of new molecular techniques to commercial animal breeding. We investigated an aspect of physiology, growth hormone (GH) metabolism, which might a priori have been expected to play a large part in the response of mouse lines selected for high or low body weight. Disruption of endogenous GH or addition of exogenous GH had similar proportionate effects on body weight in both lines of mice (although differences in body composition arose) suggesting that neither the production of GH nor receptor sensitivity to GH had been altered as a result of selection. This supports a 'pleiotropic model' of the response to selection: that many genes with diverse metabolic roles all contribute to the divergent phenotype. This result has significant commercial implications as it suggests that artificial selection, transgenic technology and environmental manipulation may be synergistic rather than antagonistic strategies.

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Section: Introductionmentioning

confidence: 89%

The role of growth hormone in lines of mice divergently selected on body weight

Hastings¹,

Bootland²,

Hill³

1993

Genet. Res.

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“…However, there are also several lines of evidence indicating that liver-derived endocrine IGF-I has a growth-promoting effect comparable to that expressed in non-hepatic tissues in IGF-I-transgenic mice on an IGF-I null background (Stratikopouloset al, 2008;Ohlsson et al, 2009;Wu et al, 2009). In line with the latter, it has been known for a long time that circulating IGF-I concentration and growth rate are correlated in the pig (Owens et al, 1999;Lee et al, 2002) and other species (Blair et al, 1989;Blum et al, 1993). As such, not only how IGF-I, EGF, and TGF-β1 act on the muscle around the time of slaughter to influence the pork quality but also how much each of endocrine and local availabilities of these growth factors contributes to this effect remains to be further studied.…”

Section: Discussionmentioning

confidence: 94%

Relationships between Pork Quality Traits and Growth Factor Concentrations in Serum and Longissimus dorsi Muscle before and at Slaughter in Female Market Pigs

Kim

Kang²,

Ha³

et al. 2013

Journal of Animal Science and Technology

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The present study was conducted to test a hypothesis that pork quality traits would be influenced by the systemic and/or local bioavailability of insulin-like growth factor-I (IGF-I), transforming growth factor-β1 (TGF-β1), or epidermal growth factor (EGF) before or at slaughter. To this end, 60 cross-bred female market pigs weighing approximately 110 kg were slaughtered, after which Longissimus dorsi muscle (LM) samples taken at slaughter (D 0) and blood samples taken at D -7 and D 0 were analyzed. The 60 carcasses rendered 36 RFN (reddish-pink, firm, and non-exudative), 16 RSE (reddish-pink, soft, and exudative), and 6 PSE (pale, soft, and exudative); 2 DFD (dark, firm, and dry) also were found but were excluded in subsequent experiments. The L* and drip loss were greater in PSE vs. RFN and RSE and in PSE and RSE vs. RFN, respectively, as they should (P<0.05). The pH45min was less in PSE vs. RFN (P<0.05); pH24h tended to be less in the former (P=0.09). The LM IGF-I and TGF-β1 as well as serum EGF concentrations were less in PSE than in RFN. None of the other LM and serum concentrations of the three growth factors differed across the three pork quality categories. The LM IGF-I and TGF-β1 concentrations and serum EGF concentration at D 0 were negatively correlated with drip loss [r = -0.36(P<0.01), -0.44 (P<0.01), and -0.32 (P<0.05), respectively]. However, none of the serum and LM growth factor variables was correlated with L* or a* (redness) of LM. Taken together, results suggest that locally expressed IGF-I and TGF-β1 and blood-borne EGF may have a beneficial effect on postmortem water holding capacity of the muscle and that pork quality traits could be predicted to some extent from concentrations of IGF-I and TGF-β1 in muscle and EGF in serum at slaughter.

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“…In a separate mouse selection experiment. Blair et al, (1989) also obtained a low realized heritabihty estimate (0.15 ± 0.12) for IGF-I concentration. A divergent selection experiment involving Homney sheep, using plasma IGF-I concentration 4 wk after weaning as the selection criterion, was initiated in 1986 (Morel et al, 1991).…”

Section: Genetic Trends Direct Responses In Igf-i Concentrationmentioning

confidence: 90%

“…Therefore, 4.48 generations of selection had occurred (generation coefficient -1). Mean plasma IGF-I concentration was 146 ± 4 vs. 113 ± 4 ng/niL for the high vs. low lines after 5 generations of selection, and 85 ± 2 vs. 58 ± 2 ng/mL {P < 0.05) for these lines after 7 generations of selection in the mouse experiment of 1990 1992 1994 1996 1998 2000 2002 2004 Birth Yur Blair et al (1988Blair et al ( , 1989. The response, measured as the divergence between the high and low IGF-I lines and averaged over 2 replicates, was 4.22 ng/mL per generation in the mouse selection experiment carried out by Baker et al (1991).…”

Section: Genetic Trends Direct Responses In Igf-i Concentrationmentioning

confidence: 94%

“…The mouse selection experiments of Blair et al (1988Blair et al ( , 1989, Siddiqui et al (1990), and Baker et al (1991) indicated that selection for increased serum IGF-I concentration would result in increased BW and BW gains, and selection for decreased IGF-I would result in reduced BW and BW gains. Therefore, the objectives of the current study were to estimate direct and correlated responses to divergent selection for serum IGF-I concentration in a herd of Angus beef cattle.…”

Section: Introductionmentioning

confidence: 99%

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Response to divergent selection for insulin-like growth factor-I concentration and correlated responses in growth traits in Angus cattle

Huang

Hines

Irvin

et al. 2011

Journal of Animal Science

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A divergent selection experiment for serum IGF-I concentration was established in 1989 at the Eastern Agricultural Research Station located in Belle Valley, Ohio. One hundred spring-calving (50 high line and 50 low line) and 100 fall-calving (50 high line and 50 low line) cows with unknown IGF-I concentrations were randomly assigned to the 2 divergent selection lines. Results of this study included 2,507 calves from the 1989 through 2005 calf crops. (Co)variance components were estimated for direct and maternal additive genetic effects using an animal model and multiple-trait, derivative-free, REML (MTDFREML) computer programs. Estimated breeding values were also obtained and regressed on years to estimate direct and correlated responses to divergent selection for serum IGF-I concentration. Estimates of direct heritability for growth traits from a single trait model were moderate and ranged from 0.33 ± 0.06 for birth weight to 0.42 ± 0.06 for preweaning BW gain. Heritability estimates for direct effects were 0.44 ± 0.07, 0.43 ± 0.07, 0.35 ± 0.06, and 0.48 ± 0.07 for IGF-I concentration at d 28, 42, and 56 of the 140-d postweaning period, and for mean IGF-I concentration, respectively. Maternal heritability and the proportion of phenotypic variance due to permanent environment effect of dam were ≤0.25 for growth traits and IGF-I concentrations. Cattle in the high line had significantly (P < 0.001) greater direct effects of mean IGF-I concentration than those in low line (high line: 66.92 ± 4.40 ng/mL vs. low line: -40.82 ± 5.18 ng/mL) in 2005. Direct responses per year for mean IGF were 5.18 ng/mL in the high line and -3.76 ng/mL in the low line. The regression of direct effects of preweaning BW gain on year were not significantly different from zero in either the high or low line. However, genetic trends were negative and significant for birth weight and postweaning BW gain in the high line and were positive and significant in the low line. Results demonstrated that divergent selection for serum IGF-I concentration in beef cattle will change the genetic potential for IGF-I concentration and that selection for lesser IGF-I concentration will result in increased birth weights and postweaning BW gains.

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Responses to divergent selection for plasma concentrations of insulin-like growth factor-1 in mice

Cited by 30 publications

References 19 publications

The role of growth hormone in lines of mice divergently selected on body weight

The role of growth hormone in lines of mice divergently selected on body weight

Relationships between Pork Quality Traits and Growth Factor Concentrations in Serum and Longissimus dorsi Muscle before and at Slaughter in Female Market Pigs

Response to divergent selection for insulin-like growth factor-I concentration and correlated responses in growth traits in Angus cattle

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