Responses to spaceflight of mouse mandibular bone and teeth

Dagdeviren, Didem; Kalajzić, Žana; Adams, Douglas; Kalajzić, Ivo; Lurie, Alan G.; Mednieks, Maija I.; Hand, Arthur R.

doi:10.1016/j.archoralbio.2018.06.008

Cited by 11 publications

(23 citation statements)

References 65 publications

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“…Of relevance, in the 9-week-old female mice exposed to spaceflight for 13 days on ST-135, it was noted that incisor length significantly increased compared to ground controls. 20 With only two studies reporting incisor parameters, and with marked differences in experimental design (i.e., sex and age of mice as well as duration of spaceflight) it is difficult to determine why differences exist, but it does appear that spaceflight may impact incisors, at least in growing mice.…”

Section: Discussionmentioning

confidence: 99%

Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station

et al. 2019

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Gravity has an important role in both the development and maintenance of bone mass. This is most evident in the rapid and intense bone loss observed in both humans and animals exposed to extended periods of microgravity in spaceflight. Here, cohabitating 9-week-old male C57BL/6 mice resided in spaceflight for ~4 weeks. A skeletal survey of these mice was compared to both habitat matched ground controls to determine the effects of microgravity and baseline samples in order to determine the effects of skeletal maturation on the resulting phenotype. We hypothesized that weight-bearing bones would experience an accelerated loss of bone mass compared to non-weight-bearing bones, and that spaceflight would also inhibit skeletal maturation in male mice. As expected, spaceflight had major negative effects on trabecular bone mass of the following weight-bearing bones: femur, tibia, and vertebrae. Interestingly, as opposed to the bone loss traditionally characterized for most weight-bearing skeletal compartments, the effects of spaceflight on the ribs and sternum resembled a failure to accumulate bone mass. Our study further adds to the insight that gravity has site-specific influences on the skeleton.

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Section: Discussionmentioning

confidence: 99%

Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station

et al. 2019

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“…Spaceflight also affects oral hard and soft tissues. Limited information is available about the effects of microgravity on oral tissues, including the mandible and teeth , salivary glands , and saliva .…”

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confidence: 99%

Response of the mouse sublingual gland to spaceflight

Dagdeviren

Beallias

Khan

et al. 2018

European J Oral Sciences

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The ultrastructure and immunohistochemistry of secretory proteins of sublingual glands were studied in mice flown on the US space shuttles Discovery [Space Transportation System (STS)-131] and Atlantis (STS-135). No differences in mucous acinar or serous demilune cell structure were observed between sublingual glands of ground (control) and flight mice. In contrast, previous studies showed autophagy and apoptosis of parotid serous acinar cells in flight mice. The expression of parotid secretory protein (PSP) in sublingual demilune cells of STS-131 flight mice was significantly increased compared with ground (control) mice but decreased in STS-135 flight mice. Similarly, expression of mucin (MUC-19) in acinar cells and expression of the type II regulatory subunit of protein kinase A (PKA-RII) in demilune cells were increased in STS-131 flight mice and decreased in STS-135 flight mice, but not significantly. Demilune cell and parotid protein (DCPP) was slightly decreased in mice from both flights, and nuclear PKA-RII was slightly increased. These results indicate that the response of salivary glands to spaceflight conditions varies among the different glands, cell types, and secretory proteins. Additionally, the spaceflight environment, including the effects of microgravity, modifies protein expression. Determining changes in salivary proteins may lead to development of non-invasive methods to assess the physiological status of astronauts.

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“…In contrast, mandibular BV decreased in both flight and habitat control mice compared to vivarium control mice from the Bion-M1 mission [48]. No differences occurred in BMD among these three groups, however.…”

Section: Effects Of Spaceflight On the Mandible 31 Microct Analysesmentioning

confidence: 72%

“…MicroCT was used to assess mandibular bone volume (BV) and bone mineral density (BMD) in mice from the STS-135 and Bion-M1 flights [48].…”

Section: Effects Of Spaceflight On the Mandible 31 Microct Analysesmentioning

confidence: 99%

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Oral Tissue Responses to Travel in Space

Mednieks¹,

Hand²

2019

Space Medicine [Working Title]

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The oral cavity functions in taste, mastication, solubilization and digestion of nutrients, as well as in respiration and speech, and participates in innate and adaptive immunity. Saliva creates and regulates the environment of the oral cavity, and changes in its composition and rate of secretion have significant effects on oral tissues as well as on systemic health. The effects of microgravity on the salivary glands, mandible and teeth were studied in mice flown on US space shuttle STS-131 and STS-135 missions, and the Russian Bion-M1 biosatellite. Significant changes in morphology and secretory protein expression occurred in parotid glands; submandibular glands were affected only on the 30-day Bion-M1 mission, indicating tissue specificity of the effects due to changes in gravity which may be similar to those taking place in humans. Changes also occurred in mandibular bone and incisor teeth. Collection of saliva is a non-invasive procedure for assessing physiological status and diagnosis of several disorders and provides a simple method for monitoring astronaut health during extended spaceflight.

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Responses to spaceflight of mouse mandibular bone and teeth

Cited by 11 publications

References 65 publications

Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station

Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station

Response of the mouse sublingual gland to spaceflight

Oral Tissue Responses to Travel in Space

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