Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study

Simmons, Cortney; Conley, May I.; Gee, Dylan G.; Baskin‐Sommers, Arielle; Deanna, M; Hoffman, Elizabeth A.; Huber, Rebekah S.; Iacono, William G.; Nagel, Bonnie J.; Palmer, Clare E.; Sheth, Chandni; Thompson, Wesley K.; Casey, B. J.

doi:10.1177/09567976211003564

Cited by 51 publications

(28 citation statements)

References 35 publications

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“…Future work with more detailed assessments will be better suited to evaluate how stress exposure may interact with sensitive periods of development. Relatedly, using an overall index of negative life events may have obscured important heterogeneity in adversity experiences; indeed, different types of environmental exposures have been linked to distinct neurobiological sequelae ( Cohodes et al, 2020 , Hong et al, 2021 , McLaughlin and Sheridan, 2016 ), and consideration of these heterogeneous effects and broader social contexts is a critical direction for future work ( Simmons and Conley et al, 2021 ). Finally, consistent with the increased statistical power to observe small effects in large samples such as the ABCD Study, the effect sizes in this study are small relative to previously published work.…”

Section: Discussionmentioning

confidence: 99%

Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study

Brieant

Sisk

Gee

2021

Developmental Cognitive Neuroscience

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Adversity exposure is a risk factor for psychopathology, which most frequently onsets during adolescence, and prior research has demonstrated that alterations in cortico-limbic connectivity may account in part for this association. In a sample of youth from the Adolescent Brain Cognitive Development (ABCD) Study (N = 4006), we tested a longitudinal structural equation model to examine the indirect effect of adversity exposure (negative life events) on later psychopathology via changes in cortico-limbic resting-state functional connectivity (rsFC). We also examined the potential protective effects of parental acceptance. Generally, cortico-limbic connectivity became more strongly negative between baseline and year 2 follow-up, suggesting that stronger negative correlations within these cortico-limbic networks may reflect a more mature phenotype. Exposure to a greater number of negative life events was associated with stronger negative cortico-limbic rsFC which, in turn, was associated with lower internalizing (but not externalizing) symptoms. The indirect effect of negative life events on internalizing symptoms via cortico-limbic rsFC was significant. Parental acceptance did not moderate the association between negative life events and rsFC. Our findings highlight how stressful childhood experiences may accelerate neurobiological maturation in specific cortico-limbic connections, potentially reflecting an adaptive process that protects against internalizing problems in the context of adversity.

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Section: Discussionmentioning

confidence: 99%

Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study

Brieant

Sisk

Gee

2021

Developmental Cognitive Neuroscience

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“…One key goal of the ABCD study is to capture the dynamic and ongoing changes that occur during multiple developmental periods, and researchers have a responsibility to account for the developmental goals and processes that occur in the given age range assessed in a given study. However, many factors influence development and, most likely, researchers will not be able to account for all these factors in one study design ( Nketia et al, 2021 , Simmons et al, 2021 ). It is therefore important to think about how research questions are theorizing, assessing, and modeling the intended developmental change ( King et al, 2018 ).…”

Section: Features Of the Abcd Studymentioning

confidence: 99%

A practical guide for researchers and reviewers using the ABCD Study and other large longitudinal datasets

Saragosa-Harris

Chaku

MacSweeney

et al. 2022

Developmental Cognitive Neuroscience

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“…Following recommendations for characterizing associations within the ABCD sample (Dick et al, 2021;Simmons et al, 2021), we replicated analyses in independent discovery and replication samples and only report consistent mixed-effects relationships across samples to protect against false positive results and assess robustness and generalizability. Effects also replicated across two independent groups of these same participants matched for study site, age, sex ethnicity, grade, highest level of parental education, handedness, combined family income, exposure to anesthesia, and family-relatedness.…”

Section: Model Variance Explainedmentioning

confidence: 99%

Effects of the physical and social environment on youth cognitive performance

Meredith

Cardenas‐Iniguez

Berman

et al. 2022

Developmental Psychobiology

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Individual differences in children's cognitive abilities impact life and health outcomes.What factors influence these individual differences during development? Here, we test whether children's environments predict cognitive performance, independent of well-characterized socioeconomic effects. We analyzed data from 9002 9-to 10-year olds from the Adolescent Brain Cognitive Development Study, an ongoing longitudinal study with community samples across the United States. Using youth-and caregiverreport questionnaires and national database registries (e.g., neighborhood crime, walkability), we defined principal components summarizing children's home, school, neighborhood, and cultural environments. In two independent samples (ns = 3475, 5527), environmental components explained unique variance in children's general cognitive ability, executive functioning, and learning/memory abilities. Furthermore, increased neighborhood enrichment was associated with an attenuated relationship between sociodemographics and general cognitive abilities. Thus, the environment accounts for unique variance in cognitive performance in children and should be considered alongside sociodemographic factors to better understand brain functioning and behavior across development.

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Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study

Cited by 51 publications

References 35 publications

Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study

Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study

A practical guide for researchers and reviewers using the ABCD Study and other large longitudinal datasets

Effects of the physical and social environment on youth cognitive performance

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