Responsive cyclodextrins as polymeric carriers for drug delivery applications

Parmar, Vijaykumar K.; Patel, Gayatri; Abu-Thabit, Nedal Y.

doi:10.1016/b978-0-08-101997-9.00024-2

Cited by 22 publications

(20 citation statements)

References 123 publications

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“…Sensitive, smart drug delivery systems were developed, which change their properties responding to thermo-, pH-, or photo-stimuli. The responsive functionalities are based on host-guest interactions, additional responsive moieties, supramolecular interactions or a polymer [36]. As it was described above, the first thermo-responsive cyclodextrin-based system was the α-cyclodextrin-PEG polypseudorotaxane, which precipitates during its formation in aqueous solution, but the complexes can be dissolved in water by heating [11].…”

Section: Responsive Cyclodextrinsmentioning

confidence: 99%

“…The smart system is able to recognize the changing of the pH and releases the active ingredient [41,42]. On the other hand, the pH of the stomach is also less than the colon pH, so using pH sensitive polymer can help to avoid the harmful effects of low pH [36,38]. The mechanism for cyclodextrins is that, the chargeable cyclodextrin molecule entraps the active pharmaceutical ingredients (API) and the pH changes alters the surface charge.…”

Section: Responsive Cyclodextrinsmentioning

confidence: 99%

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Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

et al. 2019

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Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity.

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Section: Responsive Cyclodextrinsmentioning

confidence: 99%

Section: Responsive Cyclodextrinsmentioning

confidence: 99%

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

et al. 2019

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“…As an oral pharmaceutical, even 8000 mg/day of HP-β-CD can be taken orally [ 11 ]. FDA cites HP-β-CD on the list of inactive pharmaceutical ingredients, and the USP/NF and EP reference HP-β-CD [ 12 , 13 ]. The use of HP-β-CD as a spice additive is highly justified.…”

Section: Resultsmentioning

confidence: 99%

Combinations of Piperine with Hydroxypropyl-β-Cyclodextrin as a Multifunctional System

Stasiłowicz

Rosiak

Tykarska

et al. 2021

IJMS

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Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood–brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase).

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“…The helical structure of amylopectin is disrupted by the available branched side chains which yield less intense reddish-brown color for the formed amylopectin-iodine complex instead of intense blue-violet color. Another class of polysaccharides nanocarriers is cyclodextrins (CDs) which are crystalline cyclic oligosaccharides consisting of α-1,4-glycosidic bonded D-glycopyranose units with glucose units arranged in a donut shape ring [103]. CDs are produced by enzymatic degradation of starch.…”

Section: Polysaccharidesmentioning

confidence: 99%

“…CDs are produced by enzymatic degradation of starch. CDs are classified as cage molecules with hydrophilic exterior and hydrophobic inner cavity which enables the formation of inclusion complexes with a variety of hydrophobic drug molecules [103], Figure 13 (III). CDs are categorized based on the number of glucose residues in their structure, for example, CD with the glucose hexamer is named as α-CD, the heptamer as β-CD and the octomer as γ-CD [104].…”

Section: Polysaccharidesmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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Encapsulation, specifically microencapsulation is an old technology with increasing applications in pharmaceutical, agrochemical, environmental, food, and cosmetic spaces. In the past two decades, the advancements in the field of nanotechnology opened the door for applying the encapsulation technology at the nanoscale level. Nanoencapsulation is highly utilized in designing effective drug delivery systems (DDSs) due to the fact that delivery of the encapsulated therapeutic/diagnostic agents to various sites in the human body depends on the size of the nanoparticles. Compared to microencapsulation, nanoencapsulation has superior performance which can improve bioavailability, increase drug solubility, delay or control drug release and enhance active/passive targeting of bioactive agents to the sites of action. Encapsulation, either micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, biologics, or bioactive drugs from natural sources as well as for diagnostics such as biomarkers. The outcome of any encapsulation process depends on the technique employed and the encapsulating material. This chapter discusses in details (1) various physical, mechanical, thermal, chemical, and physicochemical encapsulation techniques, (2) types and classifications of natural polymers (polysaccharides, proteins, and lipids) as safer, biocompatible and biodegradable encapsulating materials, and (3) the recent advances in using lipids for therapeutic and diagnostic applications. Polysaccharides and proteins are covered in the second part of this chapter.

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Responsive cyclodextrins as polymeric carriers for drug delivery applications

Cited by 22 publications

References 123 publications

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

Combinations of Piperine with Hydroxypropyl-β-Cyclodextrin as a Multifunctional System

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

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