Responsive Polypseudorotaxane Hydrogels Triggered by a Compatible Stimulus of CO<sub>2</sub>

Yan, Diwei; Liu, Sa; Jia, Yong‐Guang; Mo, Lina; Qi, Dawei; Wang, Jin; Chen, Yunhua; Li, Ren

doi:10.1002/macp.201900071

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…Taking advantage of precisely defined stoichiometry in guest−host interactions, these physically crosslinked supramolecular hydrogels own greater homogeneity and more predictable properties than that of other physical crosslinking hydrogels (e.g., hydrophobic or electrostatic interaction‐based hydrogels). [ 169 ] In creating guest−host hydrogels, cyclodextrins (CD), [ 44,45,170,171 ] and cucurbit[n]uril (CB[n]) [ 46,172–174 ] serving as common host motifs that interact with their respective guests to form dynamically reversible bonds that give rise to viscoelasticity in the hydrogels. For example, HA‐based supramolecular hydrogels were fabricated through mixing of guest macromere (adamantine modified HA, Ad‐HA) and host macromere (β‐cyclodextrin modified HA, CD‐HA) ( Figure A).…”

Section: Tunable Viscoelastic Hydrogels Formed Through Varying Crosslinking Strategiesmentioning

confidence: 99%

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Han

Yang

et al. 2021

Adv Funct Materials

113

121

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The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and displays time‐dependent responses to deformation or mechanical loading, in terms of viscoelastic behaviors (e.g., stress relaxation and creep). Viscoelasticity of the ECM plays a critical role in development, homeostasis, and tissue regeneration, and its implication in disease progression has also been recognized recently. Hydrogels with tunable viscoelastic properties hold a great promise to recapitulate such time‐dependent mechanics found in native ECM, which have been recently used to regulate cell behavior and guide cell fate. Here the importance of tissue viscoelasticity is first highlighted, the molecular mechanisms of hydrogel viscoelasticity are summarized, and characterization techniques used at the macroscale and microscale are reviewed. Then, recent advances in developing novel hydrogels with tunable viscoelasticity through varying crosslinking strategies, engineering of viscoelastic cell microenvironment and its substantial effects on cell behavior and fate are described, and the underlying mechanobiology mechanisms are subsequently discussed. Finally, the ongoing challenges and future perspectives on the design and modulation of viscoelastic hydrogels and the mechanobiology mechanisms on cellular responses to viscoelastic cell microenvironment are proposed.

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Section: Tunable Viscoelastic Hydrogels Formed Through Varying Crosslinking Strategiesmentioning

confidence: 99%

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Han

Yang

et al. 2021

Adv Funct Materials

113

121

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“…Different strategies for hydrogel CO 2 sensing: (A) selective protonation of PDMAEMA over PMMA units triggering gelation, (B) protonation equilibria of 2-aminobenzimidazole which changes its binding affinity to αCD, and (C) triggering wormlike micelle formation by protonation of TMPDA by dissolved CO 2 . Adapted from ref , published by the Royal Society of Chemistry.…”

Section: Hydrogel Molecular Sensors and Biosensorsmentioning

confidence: 99%

“…Pseudorotaxane hydrogels comprising poly(ethylene glycol) (PEG) and α-cyclodextrins (αCD) can also be modified to show CO 2 responsiveness . As shown in Figure B, the addition of 2-aminobenzimidazole to the hydrogel triggered gel collapse, as it forms stronger supramolecular inclusion complexes with αCD, forcing the latter to de-thread from PEG.…”

Section: Hydrogel Molecular Sensors and Biosensorsmentioning

confidence: 99%

Bottom-Up Engineering of Responsive Hydrogel Materials for Molecular Detection and Biosensing

Lim

Goh

Loh

2020

ACS Materials Lett.

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Molecular sensors respond to target molecules in their surroundings to detect and sometimes even quantify their concentrations. Traditionally comprised of small organic molecules or metal complexes, these technologies have been essential to biomedical and environmental monitoring, ensuring human health, safety, and general well-being. In the past two decades, analyte-responsive hydrogels have been an emerging technology receiving vast research attention worldwide. Hydrogels capable of detecting a vast array of analytes, including inorganic ions, carbohydrates, thiols, gases, biomolecules (nucleic acids and proteins), and even microorganisms such as bacteria and viruses, have been developed. With the added advantages of bottom-up design at the molecular level and biocompatibility, molecular detection using hydrogel sensors is typically simple to perform, and hydrogels can be integrated with electronic devices to enhance detection sensitivity, or with biomedical devices for in vitro and in vivo studies. Herein, we discuss a range of innovative strategies that have been developed for engineering hydrogel molecular sensors, with emphasis on "bottom-up" molecular engineering to achieve analyte selectivity and sensitivity.

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“…Adding 2-aminobenzimidazole changed the obtained PEG/α-CD hydrogels into a solution, which can replace PEG chains because 2-aminobenzimidazole with α-CD has a higher association constant (K a ) than PEG. Purging the solution with CO 2 regenerates the supramolecular hydrogel ( Figure 5) [112].…”

Section: α-Cyclodextrin/linear Polymer-based Polypseudorotaxane Hydromentioning

confidence: 99%

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

2019

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Supramolecular hydrogels that are based on inclusion complexes between α-cyclodextrin and (co)polymers have gained significant attention over the last decade. They are formed via dynamic noncovalent bonds, such as host-guest interactions and hydrogen bonds, between various building blocks. In contrast to typical chemical crosslinking (covalent linkages), supramolecular crosslinking is a type of physical interaction that is characterized by great flexibility and it can be used with ease to create a variety of "smart" hydrogels. Supramolecular hydrogels based on the self-assembly of polypseudorotaxanes formed by a polymer chain "guest" and α-cyclodextrin "host" are promising materials for a wide range of applications. α-cyclodextrin-based polypseudorotaxane hydrogels are an attractive platform for engineering novel functional materials due to their excellent biocompatibility, thixotropic nature, and reversible and stimuli-responsiveness properties. The aim of this review is to provide an overview of the current progress in the chemistry and methods of designing and creating α-cyclodextrin-based supramolecular polypseudorotaxane hydrogels. In the described systems, the guests are (co)polymer chains with various architectures or polymeric nanoparticles. The potential applications of such supramolecular hydrogels are also described.

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Responsive Polypseudorotaxane Hydrogels Triggered by a Compatible Stimulus of CO₂

Cited by 7 publications

References 33 publications

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Bottom-Up Engineering of Responsive Hydrogel Materials for Molecular Detection and Biosensing

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

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Responsive Polypseudorotaxane Hydrogels Triggered by a Compatible Stimulus of CO2

Cited by 7 publications

References 33 publications

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Bottom-Up Engineering of Responsive Hydrogel Materials for Molecular Detection and Biosensing

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

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Responsive Polypseudorotaxane Hydrogels Triggered by a Compatible Stimulus of CO₂