Responsiveness and minimal clinically important difference of SGRQ-I and K-BILD in idiopathic pulmonary fibrosis

Prior, Thomas Skovhus; Hoyer, Nils; Hilberg, Ole; Shaker, Saher Burhan; Davidsen, Jesper Rømhild; Bendstrup, Elisabeth

doi:10.1186/s12931-020-01359-3

Cited by 29 publications

(35 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exclusion criteria were intellectual or linguistic barriers preventing the completion of questionnaires. ILD-specific HRQL questionnaires have been validated in the same cohort [19][20][21].…”

Section: Study Subjectsmentioning

confidence: 99%

Clusters of comorbidities in idiopathic pulmonary fibrosis

Prior

Hoyer

Hilberg

et al. 2021

Respiratory Medicine

Self Cite

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Study Subjectsmentioning

confidence: 99%

Clusters of comorbidities in idiopathic pulmonary fibrosis

Prior

Hoyer

Hilberg

et al. 2021

Respiratory Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…12 studies made use of the ILD-specific King A limited number of studies used disease-specific (IPF) instruments, although many of the studies were conducted after their development in 2010. Of these, five studies [52,[70][71][72][73] used the disease-specific format of the SGRQ, the SGRQ-I, and three used "A Tool to Assess Quality of life in IPF" (ATAQ-IPF) [44,48,74]. supplementary material S9.…”

Section: Hrqol Measurement Instrumentsmentioning

confidence: 99%

Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease presenting in persons 50 years and older. Through a comprehensive review of available studies, we aimed to assess health-related quality of life (HRQoL) of people living with IPF and the instruments used in this assessment.Searches were conducted up to May, 2020. Quality appraisal and data extraction were performed using pre-designed forms. Narrative synthesis approach was used to report results of the systematic review and a random effects model was used for the meta-analysis. A leave-one-out sensitivity analysis was performed, and a trim and fill method was used to assess publication bias.The review included 134 studies. The most used instruments to measure HRQoL were St George's Respiratory Questionnaire (SGRQ), Short Form 36 (SF36) and EuroQoL (EQ5D). Standardised mean scores (95% confidence interval) for these instruments were as follows: SGRQ total score: 44.72 (42.21–47.22); SF36 physical component score (PCS): 37.00 (34.74–39.26) SF36 mental component score (MCS): 50.18 (48.41–51.95); King's Brief Interstitial Lung Disease questionnaire total score: 58.38 (55.26–61.51); and EQ5D utility: 0.73 (0.68–0.79). Analysis of standardised means for both SGRQ and SF36 demonstrated worse scores in physical health domains as compared to mental health domains.This systematic review confirms that IPF negatively affected HRQoL, mostly impacting the physical health domains. This study also demonstrated that a diverse number of instruments are used to evaluate HRQoL. In view of this diversity, a standardised approach to measurement of HRQoL for IPF is important to ensure that comparisons made are reliable.

show abstract

“…No clear patterns of disease behaviour were observed for IPF versus non-IPF ILD for PROs. In patients with IPF, EQ-5D-5L health state VAS score and K-BILD total score tended to worsen over time, but these changes did not exceed previously reported ranges of the minimal clinically important difference (MCID) [ 29 , 30 ]. In patients with non-IPF ILD, the improvements from baseline in EQ-5D-5L health state VAS score and K-BILD total score were not greater than the previously reported range of MCIDs [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 55%

“…In patients with IPF, EQ-5D-5L health state VAS score and K-BILD total score tended to worsen over time, but these changes did not exceed previously reported ranges of the minimal clinically important difference (MCID) [ 29 , 30 ]. In patients with non-IPF ILD, the improvements from baseline in EQ-5D-5L health state VAS score and K-BILD total score were not greater than the previously reported range of MCIDs [ 29 , 30 ]. However, in patients with IPF, the deterioration from baseline in EQ-5D index score was within the reported MCID range of 0.005–0.054 [ 29 ] and the same applied for the improvement from baseline in EQ-5D index score in patients with non-IPF ILD [ 29 ].…”

Section: Discussionmentioning

confidence: 55%

Disease Behaviour During the Peri-Diagnostic Period in Patients with Suspected Interstitial Lung Disease: The STARLINER Study

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction Disease behaviour may guide diagnosis and treatment decisions in patients with interstitial lung disease (ILD). STARLINER aimed to characterise disease behaviour in patients with suspected ILD during the peri-diagnostic period using real-time home-based assessments. Methods STARLINER (NCT03261037) was an international, multicentre study. Patients ≥ 50 years old with suspected ILD were followed throughout the peri-diagnostic period, consisting of a pre-diagnostic period (from enrolment to diagnosis) and a post-diagnostic period (from diagnosis to treatment initiation). Study length was variable (≤ 18 months). The primary endpoint was time-adjusted semi-annual forced vital capacity (FVC) change measured during the peri-diagnostic period using daily home spirometry in patients with idiopathic pulmonary fibrosis (IPF). Secondary outcomes included changes in FVC (home spirometry) in patients with non-IPF ILD, changes in FVC (site spirometry), changes in physical functional capacity measured by daily home accelerometry and site 6-min walk distance (6MWD), and changes in patient-reported outcomes (PROs) in IPF or non-IPF ILD. Results Of the 178 patients enrolled in the study, 68 patients were diagnosed with IPF, 62 patients were diagnosed with non-IPF ILD, 9 patients received a non-ILD diagnosis and 39 patients did not receive a diagnosis. Technical and analytical issues led to problems in applying the prespecified linear regression model to analyse the home FVC data. Time-adjusted median (quartile [Q]1, Q3) semi-annual FVC change during the peri-diagnostic period measured using home and site spirometry, respectively, was – 147.7 (– 723.8, 376.2) ml and – 149.0 (– 314.6, 163.9) ml for IPF and 19.1 (– 194.9, 519.0) ml and – 23.4 (– 117.9, 133.5) ml in non-IPF ILD. A greater decline in steps per day was observed for IPF versus non-IPF ILD, whereas an increase in 6MWD was observed for patients with IPF versus a decline in 6MWD for patients with non-IPF ILD. No clear patterns of disease behaviour were observed for IPF versus non-IPF ILD for PROs. Conclusions Despite home spirometry being feasible for most patients and centres, technical and analytical challenges in the home-based assessments prevented firm conclusions regarding disease behaviour. This highlights that further optimisation of the technology and analysis methods is required before widespread implementation. Trial Registration NCT03261037. Supplementary Information The online version contains supplementary material available at 10.1007/s12325-021-01790-y.

show abstract

Responsiveness and minimal clinically important difference of SGRQ-I and K-BILD in idiopathic pulmonary fibrosis

Cited by 29 publications

References 35 publications

Clusters of comorbidities in idiopathic pulmonary fibrosis

Clusters of comorbidities in idiopathic pulmonary fibrosis

Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis

Disease Behaviour During the Peri-Diagnostic Period in Patients with Suspected Interstitial Lung Disease: The STARLINER Study

Contact Info

Product

Resources

About