Responsiveness assessment of cell cultures exposed to poly(tartaric acid) and its corresponding magnetic nanostructures

Ganea, Iolanda-Veronica; Nan, Alexandrina; Ciorîță, Alexandra; Turcu, Rodica; Baciu, Călin

doi:10.1016/j.molstruc.2021.131459

Cited by 2 publications

(4 citation statements)

References 41 publications

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“…The cell viability and consequent membrane integrity were assessed through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays, respectively. The methodologies used are described in a previous paper [35]. Briefly, cell lines were left to attach to the 96 wells plate for 24 h at different confluences (10 4 cancerous cell lines and 12 × 10 3 normal cell lines).…”

Section: Cytotoxicity Of the Compoundsmentioning

confidence: 99%

Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation

Marc,

Stana,

Tertiş

et al. 2023

IJMS

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Oxidative stress is linked to a series of diseases; therefore, the development of efficient antioxidants might be beneficial in preventing or ameliorating these conditions. Based on the structure of a previously reported compound with good antioxidant properties and on computational studies, we designed several catechol derivatives with enhanced antioxidant potential. The compounds were synthesized and physicochemically characterized, and their antioxidant activity was assessed through different antiradical, electron transfer and metal ions chelation assays, their electrochemical behavior and cytotoxicity were studied. The results obtained in the in vitro experiments correlated very well with the in silico studies; all final compounds presented very good antioxidant properties, generally superior to those of the reference compounds used. Similarly, the results obtained from studying the compounds’ electrochemical behavior were in good agreement with the results of the antioxidant activity evaluation assays. Regarding the compounds’ cytotoxicity, compound 7b had a dose-dependent inhibitory effect against all cell lines. In conclusion, through computer-aided design, we developed several catechol thiazolyl-hydrazones with excellent antioxidant properties, of which compound 7b, with two catechol moieties in its structure, exhibited the best antioxidant activity.

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Section: Cytotoxicity Of the Compoundsmentioning

confidence: 99%

Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation

Marc,

Stana,

Tertiş

et al. 2023

IJMS

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“…This method of synthesis also allows for easy scalability, making it a promising candidate for future industrial applications [58]. Additionally, the polymer is biocompatible [59] and should easily degrade due to its ester bonds. Despite its potential, poly(tartaric acid) has only been used to coat magnetite nanoparticles in a secondary step after co-precipitation synthesis of uncoated magnetite nanoparticles [58,59].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, the polymer is biocompatible [59] and should easily degrade due to its ester bonds. Despite its potential, poly(tartaric acid) has only been used to coat magnetite nanoparticles in a secondary step after co-precipitation synthesis of uncoated magnetite nanoparticles [58,59]. Nonetheless, it has several advantages as a coating for nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Green Synthesis of Gold, Silver, Copper, and Magnetite Particles Using Poly(tartaric acid) Simultaneously as Coating and Reductant

Bunge,

Radu,

Borodi

et al. 2023

Polymers

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Poly(tartaric acid) is a relatively recently described polymer that can be easily synthesized and scaled up from a readily available renewable material (tartaric acid). This article demonstrates its use in a green synthesis of gold nanoparticles, silver nanoparticles, copper particles, and magnetite nanoparticles. In this case poly(tartaric acid) acts both as a reductant and as a coating agent. To our knowledge this is the first green synthesis of several different types of nanoparticles using only one reagent (polytartrate) as both reductant and coating. The resulting particles were analyzed by XRD, TEM/SEM, EDX, FTIR, DLS, zeta-potential, XPS, and UV/VIS spectroscopy. Preliminary studies of the thermal behavior of mixtures of different types of particles with poly(tartaric acid) were also conducted. The obtained particles show different sizes depending on the material, and the coating allows for better dispersibility as well as potential further functionalization, making them potentially useful also for other applications, besides the inclusion in polymer composites.

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Responsiveness assessment of cell cultures exposed to poly(tartaric acid) and its corresponding magnetic nanostructures

Cited by 2 publications

References 41 publications

Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation

Discovery of New Hydrazone-Thiazole Polyphenolic Antioxidants through Computer-Aided Design and In Vitro Experimental Validation

Green Synthesis of Gold, Silver, Copper, and Magnetite Particles Using Poly(tartaric acid) Simultaneously as Coating and Reductant

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