Responsiveness of Isolated Veins to Vasoactive Substances

Toda, Noboru; Okamura, Tomio

doi:10.1007/978-4-431-68385-8_1

Veins 1993

DOI: 10.1007/978-4-431-68385-8_1

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Responsiveness of Isolated Veins to Vasoactive Substances

Noboru Toda¹,

Tomio Okamura

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2002

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“…The vasodilative effect of NO is more evident in pulmonary veins than in the arteries also in other mammals (2,5). In contrast, in the other vasculature, such as mesenteric and femoral, there is no difference in the vasodilative response to NO or NO donors, such as nitroglycerin and sodium nitroprusside, between arteries and veins (12,13). However, more marked dilatation in veins than in arterioles has long been recognized (14).…”

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Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins

Ayajiki

Okamura

Noda

et al. 2002

Japanese Journal of Pharmacology

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ABSTRACT-In dog pulmonary arterial and venous strips without endothelium under treatment with prazosin, nicotine induced relaxation that was abolished by N G -nitro-L-arginine, hexamethonium and methylene blue. L-Arginine antagonized the N G -nitro-L-arginine action. Neurogenic relaxations tended to be more evident in the vein. Nitric oxide (NO)-induced relaxations were greater in the veins than in the arteries. Concentrations of NO to induce the same magnitude of relaxation as that to nicotine were higher in the arteries. In conclusion, dog pulmonary arteries and veins are innervated by nitroxidergic (nitrergic) nerves, and NO is released by nerve stimulation with nicotine in a larger amount in the artery than the vein.Keywords: Nicotine, Nitroxidergic (nitrergic) nerve, Pulmonary vasculature Inhalation of nitric oxide (NO) is recognized as a useful therapy for primary pulmonary hypertension, persistent pulmonary hypertension of the neonate and adult respiratory distress syndrome (1). The effect is considered to be due mainly to reduced arterial resistance and also to bronchiolar smooth muscle relaxation. Endogenous NO derived from the endothelium (2) or autonomic efferent nerve (3, 4) of pulmonary arteries is expected to play an important role in the regulation of vascular resistance.Inhaled NO acts mainly on pulmonary arterioles via alveoli, thus resulting in therapeutic effectiveness locally. Intravenously applied NO donors, such as nitroglycerin, nitroprusside, Sin 1, etc., and endothelium-derived NOreleasing substances also act on pulmonary veins and systemic vasculature. Some studies have indicated the different responsiveness to chemical stimuli of pulmonary arteries and veins (2, 5, 6). However, no information is available concerning quantitative analyses of the heterogeneous response to nitroxidergic nerve stimulation and NO in the arteries and veins.There is a discrepancy in mechanisms of neurogenic vasodilatation in pulmonary arteries. It has been reported that NO is involved in vasodilation of the guinea pig pulmonary arteries (3, 4), whereas CGRP acts as a neurotransmitter in the same arteries (7,8).The aim of the present study was to clarify the mechanism underlying neurogenic relaxation and to determine different responsiveness to chemical perivascular nerve stimulation by nicotine and exogenously applied NO of canine pulmonary arteries and veins. The nicotine-induced response is considered to be caused by nerve stimulation from the functional and histological studies in canine penile veins (9). Beagle dogs of either sex, weighing 9 to 13 kg, were used for the present study. The Animal Care and Use Committee at our University approved the use of dog blood vessels. The dogs were anesthetized with thiopental sodium (20 mg /kg, i.v.) and killed by bleeding from carotid arteries. Lungs were rapidly removed. Second or third branches of intrapulmonary arteries and accompanying veins (0.7 -0.9 mm diameter) were isolated and helically cut into strips of approx. 20-mm length. The endothelium was removed b...

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Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins

Ayajiki

Okamura

Noda

et al. 2002

Japanese Journal of Pharmacology

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Responsiveness of Isolated Veins to Vasoactive Substances

Cited by 1 publication

References 12 publications

Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins

Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins

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