Response-to-Intervention (RtI), a framework for improving academic and behavioral outcomes for all students, can be viewed as a current example of an educational change initiative. Given the difficulties that some schools may be experiencing when implementing RtI effectively, it is important to examine prior educational change conceptualizations and research for factors that may facilitate or impede current educational reform. The purpose of this article is to (a) present RtI as a current educational reform initiative, (b) use Fullan's (2007) theoretical model as a framework through which to present information related to educational change, and (c) provide suggestions regarding how such educational change literature can inform and improve the implementation and future sustainability of RtI in schools.