Responsivity of Pituitary Gonadotropes to Luteinizing Hormone-releasing Factor in Idiopathic Precocious Puberty, Precocious Thelarche, Precocious Adrenarche, and in Patients Treated with Medroxyprogesterone Acetate

Reiter, Edward O.; Kaplan, Selna L.; Conte, Felix A.; Grumbach, Melvin M.

doi:10.1203/00006450-197502000-00011

Cited by 99 publications

(13 citation statements)

References 12 publications

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“…This study would not suggest that the maturation of the hypothalamus and pituitary occurs with premature adrenarche in the same way as that indicated by gonadotropin response to LRH during normal puberty (2,4,5) or among girls with sexual precocity (6). The increase in urinary 17-ketosteroids noted in 3 of 5 patients apparently occurs independent of gonadotropin secretion.…”

Section: Discussionmentioning

confidence: 64%

“…This response involves a peak rise from 400 to 1600 per cent above the baseline. An exaggerated response is also suggested by the rise of 700 to 1300 per cent among the girls with adrenarche and suggests a prepubertal response, especially since FSH responses may decrease with puberty (4,6). Further studies with control prepubertal female patients are required to determine whether the LH and estradiol response among the girls with premature adrenarche is increased.…”

Section: Discussionmentioning

confidence: 89%

“…Furthermore, a testosterone response is not present among prepubertal boys but occurs among pubertal boys (5). A recent report indicates a pubertal response among patients with precocious puberty (6). This was based on an elevated response of LH to LRH and an increase in estradiol among girls.…”

mentioning

confidence: 95%

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Gonadotropin and Sex Steroid Response to Luteinizing Hormone-Releasing Hormone in Patients with Premature Adrenarche

Lee

Gareis

1976

The Journal of Clinical Endocrinology & Metabolism

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 89%

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Gonadotropin and Sex Steroid Response to Luteinizing Hormone-Releasing Hormone in Patients with Premature Adrenarche

Lee

Gareis

1976

The Journal of Clinical Endocrinology & Metabolism

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“…MPA and CPA reverse or arrest the progression of secondary sex characterises but have little to no effect on hormonal suppression [117,118] and auxological outcome [4,119]. In addition, both agents have undesirable side effects [4,120].…”

Section: Treatment Optionsmentioning

confidence: 97%

Gonadotropin-Releasing Hormone Analogue Treatment for Precocious Puberty

Heger

Sippell

Partsch

2005

Endocrine Development

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Central precocious puberty (CPP) is the premature onset of puberty due to a precocious activation of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. This condition results in accelerated development of secondary sex characteristics, accelerated bone maturation, impaired final height with disproportioned body appearance and can have a disturbing impact on the psychosocial behavior of children suffering from CPP. It is therefore necessary to assess the hormonal status of children who show pubertal signs before the age 8 years in girls and 9 years in boys. The indication for treatment should be made after evaluating pubertal progression, progression of bone age maturation and final height prognosis, development of reproductive function, and psychosocial adjustment and well-being. This paper summarizes the experience of GnRH agonist treatment, which is momentarily the treatment of choice for central precocious puberty in children.

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“…These results suggest that LHRH a is an effective adjunct to hydrocortisone and fludrocortisone in the treatment of true precocious puberty complicating CAH. (J Clin Endocrinol Metab 58: 857,1984) ONGENITAL adrenal hyperplasia (CAH) has long been recognized as a major cause of precocious pseudopuberty (premature secondary sexual development without activation of pubertal LH and FSH secretion) (1)(2)(3)(4)(5)(6)(7)(8). Elevated adrenal androgen production in this disorder causes pubic and axillary hair development, penile or clitoral enlargement, rapid growth, and advanced bone age.…”

mentioning

confidence: 97%

True Precocious Puberty Complicating Congenital Adrenal Hyperplasia: Treatment with a Luteinizing Hormone-Releasing Hormone Analog*

Pescovitz

Comite

Cassorla

et al. 1984

The Journal of Clinical Endocrinology & Metabolism

143

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Congenital adrenal hyperplasia (CAH) is a recognized cause of precocious pseudopuberty. Some children with CAH also develop true precocious puberty with early maturation of the hypothalamic-pituitary-gonadal axis. We have seen four such children (three boys and one girl) who had the diagnosis of CAH made between the ages of 3 and 6 yr. These patients were treated with standard doses of hydrocortisone and fludrocortisone. A diagnosis of true precocious puberty was made because of testicular enlargement in the boys, breast development in the girl, progressive pubic hair development, rapid growth, and rapid bone age maturation. Plasma steroid levels were elevated for age, and gonadotropin levels were within the normal pubertal range, both basally and in response to LHRH stimulation. We treated these children with daily sc injections of a LHRH analog (LHRHa) for 6-18 months in addition to the standard hydrocortisone and fludrocortisone therapy for CAH. LHRHa significantly decreased basal plasma LH and FSH, peak LH and FSH responses to native LHRH, and testosterone levels. Testis size decreased in the males, and breast development regressed in the female. LHRHa therapy led to significant decreases in linear growth rate, ulnar growth rate, and rate of bone age advancement. These results suggest that LHRHa is an effective adjunct to hydrocortisone and fludrocortisone in the treatment of true precocious puberty complicating CAH.

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Responsivity of Pituitary Gonadotropes to Luteinizing Hormone-releasing Factor in Idiopathic Precocious Puberty, Precocious Thelarche, Precocious Adrenarche, and in Patients Treated with Medroxyprogesterone Acetate

Cited by 99 publications

References 12 publications

Gonadotropin and Sex Steroid Response to Luteinizing Hormone-Releasing Hormone in Patients with Premature Adrenarche

Gonadotropin and Sex Steroid Response to Luteinizing Hormone-Releasing Hormone in Patients with Premature Adrenarche

Gonadotropin-Releasing Hormone Analogue Treatment for Precocious Puberty

True Precocious Puberty Complicating Congenital Adrenal Hyperplasia: Treatment with a Luteinizing Hormone-Releasing Hormone Analog*

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