Objectives: To assess the performance of the commercially available Magmaris sirolimuseluting bioresorbable scaffold (BRS) with invasive imaging at different time points.Background: Coronary BRS with a magnesium backbone have been recently studied as an alternative to polymeric scaffolds, providing enhanced vessel support and a faster resorption rate. We aimed to assess the performance of the commercially available Magmaris sirolimus-eluting BRS at different time points.Methods: A prospective, single-center, nonrandomized study was performed at the Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. Six patients with stable de novo coronary artery lesions underwent single-vessel revascularization with the Magmaris sirolimus-eluting BRS. Invasive follow-up including intravascular imaging using optical coherence tomography (OCT) was performed at different time points.Results: At a median of 8 months (range 4-12 months) target lesion failure occurred in one patient. Angiography revealed a late lumen loss of 0.59 ± 0.39 mm, a percentage diameter stenosis of 39.65 ± 15.81%, and a binary restenosis rate of 33.3%. OCT showed a significant reduction in both minimal lumen area (MLA) and scaffold area at the site of the MLA by 43.44 ± 28.62 and 38.20 ± 25.74%, respectively. A fast and heterogeneous scaffold degradation process was found with a significant reduction of patent struts at 4-5 months.Conclusions: Our findings show that the latest iteration of magnesium BRS suffers from premature dismantling, resulting in a higher than expected decrease in MLA. K E Y W O R D S bioresorbable scaffolds, constrictive remodeling, Magmaris sirolimus-eluting bioresorbable scaffold, scaffold bioresorption, scaffold collapse, scaffold recoil Abbreviations: AMS, absorbable magnesium scaffolds; BRS, bioresorbable scaffold; DAPT, dual antiplatelet therapy; DES, drug-eluting stent; DS, diameter stenosis; LA, lumen area; LLL, late lumen loss; MLA, minimal lumen area; MSA, minimal scaffold area; NC, noncompliant; OCT, optical coherence tomography; post-PCI, post-percutaneous coronary intervention; pre-PCI, prepercutaneous coronary intervention; QCA, quantitative coronary analysis; RVD, reference vessel diameter; SA, scaffold area; SE-MEA, scaffold expansion according to manufacturer's expected area; SE-RVA, scaffold expansion according to reference vessel area.