Resting cerebral glucose metabolism and perfusion patterns in women with posttraumatic stress disorder related to sexual assault

Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis

“…1), of which 19 papers12192021222324262728293031323335363738 met the inclusion criteria. No additional eligible articles were found in the reference lists of the selected studies.…”

“…For two studies1921 which reported between-group differences between in functional connectivity between multiple brain regions as well as in regional brain activities, we took only the regional brain activity results into account. One study24 used two different modalities (SPECT and PET) with the same PTSD group but different control groups, and in this case we selected the larger control group. One study22 which showed significant statistical heterogeneity (p < 0.005) was excluded.…”

“…Finally 15 studies were included in the meta-analysis (Table 1). These included 6 studies122133353637 that recruited partial PTSD patients with comorbidity and 3 studies212433 that recruited partial PTSD patients taking medication at the time of study. Three studies122933 employing a three-group design contributed separately to the TEC and NTC analyses.…”

“…Several studies have examined resting brain activity in PTSD1219202122232425262728, revealing significantly different spontaneous activity in the cerebral cortex (e.g. superior temporal gyrus, medial prefrontal cortex (mPFC), inferior parietal lobule and middle occipital gyrus), the limbic regions (e.g.…”

“…However, the results have not been wholly consistent. For example, some studies have reported increased activation of the insula in PTSD272930, while others reported decreased3132 or absent activation2433 in the insula. There are several possible reasons for this variation.…”