Resting energy expenditure and weight loss in human immunodeficiency

Süttmann, U.; Ockenga, Johann; Hoogestraat, L.; Selberg, O.; Schedel, I.; Deicher, H.; Müller, M.J.

doi:10.1016/0026-0495(93)90277-u

Cited by 46 publications

(20 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8,[38][39][40] In adults with HIV-1 infection, even those with minimal symptoms have a resting energy expenditure that increases with advancing HIV-1 stage. 9,10 Few studies have evaluated total energy expenditure in adults or children, 39-41 yet total energy expenditure does not appear to be different between HIV-1-infected children with growth failure, as defined by a linear growth velocity of less than the 5th percentile, 39,40 and those without growth failure.…”

Section: Discussionmentioning

confidence: 99%

“…7 Energy metabolism is less well-defined, but some studies suggest that resting energy expenditure in infected children is slightly higher than predicted, 8 which is also the case in adults with HIV-1 infection. 9,10 Children with HIV-1 infection are also more likely than noninfected children to have problems absorbing nutrients, which can impair growth. 11,12 Comorbidities or chronic clinical conditions associated with HIV-1 can influence growth and nutrition by altering any of the aforementioned factors.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Maternal and Infant Factors Associated With Failure to Thrive in Children With Vertically Transmitted Human Immunodeficiency Virus-1 Infection: The Prospective, P2C2 Human Immunodeficiency Virus Multicenter Study

et al. 2001

View full text Add to dashboard Cite

Objective-Many children with human immunodeficiency virus-1 (HIV-1) have chronic problems with growth and nutrition, yet limited information is available to identify infected children at high risk for growth abnormalities. Using data from the prospective, multicenter P 2 C 2 HIV study, we evaluated the relationships between maternal and infant clinical and laboratory factors and impaired growth in this cohort.Methods-Children of HIV-1-infected women were enrolled prenatally or within the first 28 days of life. Failure to thrive (FTT) was defined as an age-and sex-adjusted weight z score ≤−2.0 SD. Maternal baseline covariates included age, race, illicit drug use, zidovudine use, CD4 + T-cell count, and smoking. Infant baseline predictors included sex, race, CD4 + T-cell count, Centers for Disease Control stage, HIV-1 RNA, antiretroviral therapy, pneumonia, heart rate, cytomegalovirus, and Epstein-Barr virus infection status.Results-The study cohort included 92 HIV-1-infected and 439 uninfected children. Infected children had a lower mean gestational age, but birth weights, lengths, and head circumferences in the 2 groups were similar. Mothers of growth-delayed infants were more likely to have smoked Copyright © 2001 by the American Academy of Pediatrics. Reprint requests to (T.L.M.) Division of Pediatric Gastroenterology and Nutrition, Box 667, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642. tracie_miller@urmc.rochester.edu. National Heart, Lung, and Blood Institute, Bethesda, MD The institutions and investigators participating in this study are listed in the "Appendix." HHS Public Access Author manuscriptPediatrics. Author manuscript; available in PMC 2015 April 03. Published in final edited form as:Pediatrics. 2001 December ; 108(6): 1287-1296. Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript tobacco and used illicit drugs during pregnancy. In repeated-measures analyses of weight and length or height z scores, the means of the HIV-1-infected group were significantly lower at 6 months of age (P < .001) and remained lower throughout the first 5 years of life. Conclusion-Clinical and laboratory factors associated with FTT among HIV-1-infected children include history of pneumonia, maternal illicit drug use during pregnancy, lower infant CD4 + T-cell count, exposure to antiretroviral therapy by 3 months of age (non-protease inhibitor), and HIV-1 RNA viral load. Keywordshuman immunodeficiency virus; children; failure to thrive; growth; malnutrition Many children with human immunodeficiency virus-1 (HIV-1) infection have chronic problems with linear growth and weight gain. 1-5 A variety of disturbed growth patterns have been described, ranging from symmetric delays in weight and length or height to severe wasting with normal length or height. The differences in growth patterns probably result from differences in disease manifestations in HIV-1-infected children. In developed countries, both weight and length or height decline in infected children as early as...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Maternal and Infant Factors Associated With Failure to Thrive in Children With Vertically Transmitted Human Immunodeficiency Virus-1 Infection: The Prospective, P2C2 Human Immunodeficiency Virus Multicenter Study

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Studies of REE in children with HIV are few (Henderson et al 1998). In adults, REE is increased in asymptomatic stages of HIV infection (Hommes et al 1991;Suttmann et al 1993) and will increase progressively with increased stage and with active infections. Studies of REE in children, although limited, have not found large differences between HIV-infected and control patients (Henderson et al 1998).…”

Section: Altered Metabolismmentioning

confidence: 99%

Nutrition in paediatric human immunodeficiency virus infection

Miller

2000

Proc. Nutr. Soc.

View full text Add to dashboard Cite

The nutritional condition of children with human immunodeficiency virus (HIV) infection continues to be a problem both in developed and developing countries. HIV-infected children grow below normal standards in both height and weight when compared with HIV-exposed non-infected children. These patterns persist over time. It is possible that acute infectious episodes and increased HIV viral burden contribute to decrements in all growth variables. Potential aetiologies for abnormal growth include inadequate dietary intake, gastrointestinal malabsorption, increased energy utilization and psycho-social problems. It is likely that all these factors contribute to the growth problems of these children to some extent. With the development of protease inhibitor anti-retroviral therapy and highly-active anti-retroviral treatment regimens, children with HIV infection in developed countries are living longer with a chronic illness. New nutritional problems have arisen with the development of the fat redistribution syndrome or lipodystrophy. Emerging problems are now being recognized, with the development of insulin resistance and truncal obesity which may potentially lead to premature cardiovascular disease.

show abstract

“…1991), and is more marked still in individuals with secondary infection (Grunfeld et al 19928;Melchior et al 1993). Such increased REE is independent of changes in body composition, but does show marked inter-individual variation (Schwenk et al 1996), such that some individuals are frankly hypometabolic (Kotler et al 1990;Suttmann et al 1993) whilst others are markedly hypermetabolic. Such observations of increased REE lead authors to suggest that hypermetabolism might be a major contributor to the weight loss seen in HIV, by increasing the demand for energy intake.…”

Section: Energy Metabolism In Human Immunodeficiency Virus Infectionmentioning

confidence: 99%

Metabolic abnormalities and wasting in human immunodeficiency virus infection

Macallan

1998

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Resting energy expenditure and weight loss in human immunodeficiency

Cited by 46 publications

References 13 publications

Maternal and Infant Factors Associated With Failure to Thrive in Children With Vertically Transmitted Human Immunodeficiency Virus-1 Infection: The Prospective, P2C2 Human Immunodeficiency Virus Multicenter Study

Maternal and Infant Factors Associated With Failure to Thrive in Children With Vertically Transmitted Human Immunodeficiency Virus-1 Infection: The Prospective, P2C2 Human Immunodeficiency Virus Multicenter Study

Nutrition in paediatric human immunodeficiency virus infection

Metabolic abnormalities and wasting in human immunodeficiency virus infection

Contact Info

Product

Resources

About