Resting energy expenditure, oxygen consumption and carbon dioxide production during sleep in children with atopic dermatitis

Abstract

Children with AD do not appear to have significant disturbance in their resting energy consumption, oxygen consumption and carbon dioxide production during sleep. These parameters do not appear to correlate with the symptomatology of pruritus and sleep disturbance. We speculate that deranged metabolism during sleep is unlikely in children with AD.

Disease severity, scratching, and sleep quality in patients with atopic dermatitis

“…Morning IL-6 levels are negatively associated with sleep quality. 30 Sleep deprivation in healthy individuals increases IL-6 and subcutaneous injections of IL-6 increases REM sleep. [31][32][33] Other data suggest that the role of elevated IL-6 in regulating the sleep-wake cycle is stronger in organisms where infection is present.…”

CDLQI, Scorad and Ness: Are they Correlated?

“…A HON index of (Obj 1, N 1) is defined as a patient with mild acute and chronic severity, whereas HON (Obj 3, N1) may represent a patient with mild disease over the past 12 months but recent acute exacerbation. Pruritus [21] and sleep disturbance [22] can also be objectively evaluated and documented with the optional portion of the HON classification. In this regard, a HON index of (Obj 1, N1, 40 g min )1 , 90%) represents a patient with mild acute and chronic severity, average wrist movement of 40 g min )1 and sleep efficiency of 90%; whereas HON (Obj 3, N3, 200 g min )1 , 75%) represents a miserable patient with severe disease, intense nocturnal itch and much sleep disturbance.…”

What happens to the severity grading by objective SCORAD if we over‐ or underestimate disease extent or intensity in patients with atopic dermatitis?

“…There are other surrogate markers and objective measurements to replace or supplement the important and annoying symptoms of itch and sleep loss 10 . For instance, itch can be measured with a wrist‐worn motion detector, and sleep disturbance can be determined by sleep efficiency study 13–16 …”