Resting Heart Rate and the Risk of Atrial Fibrillation

Liu, Xiao; Guo, Ninghong; Zhu, Wenzhen; Zhou, Quan; Liu, Menglu; Chen, Chen; Yuan, Ping; Wan, Rong; Hong, Kui

doi:10.1536/ihj.18-470

Cited by 32 publications

(36 citation statements)

References 55 publications

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“…This method needs at least two SUA levels and the corresponding RRs with 95% CI. When the median or mean SUA was not provided and reported in ranges, we assumed the midpoint of lower and upper boundaries as the level of each SUA 19 . If the highest or lowest category was open‐ended, open‐ended interval length was the same as the adjacent interval 20 .…”

Section: Methodsmentioning

confidence: 99%

Serum uric acid and incident atrial fibrillation: A systematic review and dose–response meta‐analysis

Zhang

Zheng

et al. 2020

Clin Exp Pharma Physio

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Atrial fibrillation is the most common cardiac arrhythmia in clinical practice, with increased cardiovascular morbidity and mortality worldwide. 1 Although multiple risk factors, including cardiovascular and non-cardiovascular risk factors have been identified, the pathophysiology of atrial fibrillation remains incompletely understood. Over 40% of the risk attributed to atrial fibrillation still remains unexplained after accounting for established risk factors. Serum uric acid (SUA) is an end product of purine derivatives in metabolism in humans. 2 A high level of SUA is associated with the deposition of UA in joints and surrounding tissues. As we know, the elevated level of SUA is a contributing factor to the pathogenesis of gout, arthritis, and chronic nephropathy. Over the past two decades years, hyperuricaemia has been also widely linked to so-called "cardio-metabolic diseases", including cardiovascular diseases and type 2 diabetes. 2,3 Moreover, in recent years, several cross-sectional studies and prospective studies have shown that a high SUA

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Section: Methodsmentioning

confidence: 99%

Serum uric acid and incident atrial fibrillation: A systematic review and dose–response meta‐analysis

Zhang

Zheng

et al. 2020

Clin Exp Pharma Physio

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“…Our study also had several limitations. First, several potential confounding variables, including sex, age, smoking, cardiorespiratory fitness, and the severity of outcomes, might modify the association between BMI and AF outcomes . Future studies should address their specific roles in “the obesity paradox” in AF.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

The obesity paradox for outcomes in atrial fibrillation: Evidence from an exposure‐effect analysis of prospective studies

et al. 2019

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The impact of obesity on the prognosis of atrial fibrillation (AF) remains controversial. We conducted an exposure-effect meta-analysis of prospective studies to clarify the relationship between body mass index (BMI) and outcomes in patients with AF. The Cochrane Library, PubMed, and Embase databases were searched through May 1, 2019. Summary relative risks (RRs) were calculated using random-effects models. Nonlinear associations were explored using restricted cubic spline models. Twenty publications involving 161,922 individuals were included. Categorical variable analysis showed that underweight was associated with an increased risk of all-cause mortality (RR: 2.6), cardiovascular death (RR: 2.91), major bleeding (RR: 1.57), stroke or systemic embolism (RR: 1.62), and a composite endpoint (RR: 2.23). In exposure-effect analysis, the risk per 5 BMI increase was reduced for adverse outcomes (RR=0.86, 95% CI: 0.80-0.92 for all-cause death; RR=0.82, 95% CI: 0.71-0.95 for cardiovascular death; RR=0.89, 95% CI: 0.84-0.95 for stroke or systemic embolism; and RR=0.78, 95% CI: 0.67-0.92 for a composite endpoint).There was a significant "U"-shaped exposure-effect relationship with all-cause death, and the nadir of the curve was observed at a BMI of approximately 28.Our results showed that underweight is associated with a worse prognosis, but that overweight and obesity are associated with improved adverse outcomes in patients with AF. KEYWORDSatrial fibrillation, body mass index, meta-analysis, obesity paradox

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“…Данные мета-анализа 2019 г. (10 исследований, 18630 эпизодов ФП у 431432 участников) показывали, что при ЧСС покоя в диапазоне от 68 до 80 уд/мин риск появления ФП наименьший [40]. Уменьшение или увеличение ЧСС на каждые 10 уд/мин за пределы этой зоны увеличивает риск развития ФП на 9% (ОР 1,09; 95%ДИ 1,06-1,12, р<0,001), или на 6% (ОР 1,06, 95%ДИ 1,03-1,08, р<0,001) относительно ЧСС 70 уд/мин.…”

Section: прогрессирование фибрилляции предсердий и клинические событиunclassified

Atrial Fibrillation: the Association with Physical Activity and the Effects of Cardiac Rehabilitation

Бубнова¹,

Аронов²

2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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The purpose of this review was to present modern studies that examine the relationship of physical activity and risk of atrial fibrillation (AF) development and the impact of cardiac rehabilitation programs in patients with all forms of AF. Data of 52 Russian and foreign scientific sources published in 1998- 2020 were presented. In our study, 48 patients with paroxysmal AF after radiofrequency ablation (RFA) were randomly assigned to a physical rehabilitation/standard therapy or control (standard therapy) group. Aerobic physical training was conducted for 6 months 3 times a week. AF is one of the most common cardiac arrhythmias. Despite modern advances, results of treatment of this disease are far from optimal. Many problems of patients with AF can be addressed through enrolment in multidisciplinary cardiac rehabilitation programs. But this question remains open. This is mainly due to the complexity of selection of physical rehabilitation program for patients with AF. It is known that physical activity can trigger an episode of AF. In the following review article, the approaches to functional capacity assessment of patient with AF are described, recommendations for prescribing safe exercise training to achieve a therapeutic effect are presented. Various aspects of the effects of physical rehabilitation are discussed, including its impact on cardiovascular risk factors, influence on atrial remodeling processes and associated biomarkers, prevention of AF progression and occurrence of cardiovascular complications. Results of our own research indicate effectiveness of physical training in patients with AF after RFA: increase in exercise duration by 18.6% (p<0.001) and load by 24.8% (p<0.01) during exercise test, increase in level of everyday physical activity by 23.8% (p=0.001); left atrium dimensions remain stable comparing with control group. That was combined with a decrease of post ablation atrial arrhythmias: after 6 months, they were registered in 4.5% of trained patients vs 17.4% of control group patients (p<0.01). Steady growth in the number of patients with AF and catheter ablation procedures around the world dictates the need for organization of multi-purpose medical rehabilitation.

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Resting Heart Rate and the Risk of Atrial Fibrillation

Cited by 32 publications

References 55 publications

Serum uric acid and incident atrial fibrillation: A systematic review and dose–response meta‐analysis

Serum uric acid and incident atrial fibrillation: A systematic review and dose–response meta‐analysis

The obesity paradox for outcomes in atrial fibrillation: Evidence from an exposure‐effect analysis of prospective studies

Atrial Fibrillation: the Association with Physical Activity and the Effects of Cardiac Rehabilitation

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