Resting regional cerebral perfusion in recent posttraumatic stress disorder

Bonne, Omer; Gilboa, Asaf; Louzoun, Yoram; Brandes, Dalia; Yona, Ilan; Lester, Hava; Barkai, Gavriel; Freedman, Nanette; Chisin, Roland; Shalev, Arieh Y.

doi:10.1016/s0006-3223(03)00525-0

Cited by 129 publications

(108 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with our results, a prior single-photonemission computed tomography (SPECT) study reported higher regional cerebral blood flow (rCBF) in the left inferior parietal gyrus (Brodmann area 40) in PTSD patients exposed to civilian traumatic events compared to traumatized controls at rest [27] . Increased blood flow in the inferior parietal lobule has also been reported in different paradigms such as symptom provocation [28] and cognitive activation [29] in patients suffering from PTSD.…”

Section: Discussionsupporting

confidence: 91%

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

et al. 2012

View full text Add to dashboard Cite

Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.

show abstract

Section: Discussionsupporting

confidence: 91%

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In civilian samples with PTSD no differences in plasma cortisol were found either (e.g. Bonne et al, 2003;Stein et al, 1997). Circadian salivary levels of basal cortisol have only been rarely investigated and those studies demonstrated contradictory results also.…”

Section: Discussionmentioning

confidence: 98%

“…In 25 of the 40 subjects with PTSD comorbid depression was found (postdisaster onset N = 18). Since several studies found no differences in cortisol levels between subjects with PTSD with or without comorbid depression (Altemus et al, 2003;Bonne et al, 2003;Lindley et al, 2004) we regarded PTSD with or without depression as one single group. Four survivors with PTSD were excluded because their symptoms were due to a focal trauma other than the fireworks disaster.…”

Section: Subjectsmentioning

confidence: 99%

Tobacco usage interacts with postdisaster psychopathology on circadian salivary cortisol

Olff

Meewisse

Kleber

et al. 2006

International Journal of Psychophysiology

View full text Add to dashboard Cite

Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) have been associated with increased rates of tobacco usage as well as with dysregulations of the hypothalamus -pituitary -adrenal (HPA) axis. At the same time tobacco also affects the HPA axis. This paper examines the relationships between PTSD, posttraumatic MDD, smoking and levels of circadian cortisol 2 -3 years postdisaster. Subjects were survivors of the Enschede fireworks disaster. The sample consisted of 38 healthy survivors, 40 subjects with PTSD, and 17 subjects with posttraumatic MDD. The Composite International Diagnostic Interview was used to determine mental disorders in accordance with DSM-IV criteria. Salivary cortisol samples were collected at home immediately upon awakening, 30 min after awakening, at noon, and at 10 p.m. Quantity of smoking was measured through self-report. The results of the study show that salivary cortisol concentrations were higher in smoking subjects. Survivors with MDD following the disaster had a flatter diurnal cortisol curve than subjects with PTSD or healthy survivors. In survivors with PTSD and healthy individuals the usual dynamic pattern of increase in cortisol past awakening was present, while we did not observe this in posttraumatic MDD. These survivors with MDD tended to use more tobacco per day, and the cortisol group differences could only be revealed when we adjusted for quantity of smoking. Smoking, which may be an important palliative coping style in dealing with posttraumatic arousal symptoms, seems to mediate the relationship between traumatic stress and the HPA-axis. D

show abstract

“…The study by Gianaros et al found that healthy individuals show heightened stressor-induced neural activation in the cingulate cortex, bilateral prefrontal cortex, and cerebellum while performing a standardized Stroop color-word interference task (Gianaros et al, 2007); however, studies of the cerebellum in PTSD patients have been very limited. In two positron emission tomography (PET) studies, abnormal activities in the cerebellum of PTSD subjects were found, including higher regional cerebral blood flow (Bonne et al, 2003) and augmented glucose absorption activity (Molina et al, 2010). Bellis et al found that the www.intechopen.com left, right, and total cerebellum were smaller in maltreated children and adolescents with PTSD.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Brain Density in Victims of Rape with PTSD in Mainland China: A Voxel-Based Analysis of Magnetic Resonance Imaging Study

Sui¹,

Li²,

Zhang³

et al. 2011

Neuroimaging for Clinicians - Combining Research and Practice

View full text Add to dashboard Cite

Resting regional cerebral perfusion in recent posttraumatic stress disorder

Cited by 129 publications

References 63 publications

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

Tobacco usage interacts with postdisaster psychopathology on circadian salivary cortisol

Abnormal Brain Density in Victims of Rape with PTSD in Mainland China: A Voxel-Based Analysis of Magnetic Resonance Imaging Study

Contact Info

Product

Resources

About