Resting-state brain alteration after a single dose of SSRI administration predicts 8-week remission of patients with major depressive disorder

Cheng, Yuqi; Xu, Jian; Arnone, Danilo; Nie, Binbin; Yu, Hongjun; Jiang, Hong-Yan; Bai, Yan; Luo, Ceng; Campbell, Rosanne; Shan, Baoci; Xu, Lin; Xu, Xiufeng

doi:10.1017/s0033291716002440

Cited by 43 publications

(36 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These early changes may be important for the therapeutic effect of antidepressants. This is supported by a recent study that found changes in resting-state functional connectivity only 5 h after a single dose of escitalopram to predict later treatment response in depressed patients (Cheng et al, 2017).…”

Section: Effect Of Mirtazapine On Large-scale Functional Connectivitysupporting

confidence: 63%

Single dose of mirtazapine modulates whole-brain functional connectivity during emotional narrative processing

Komulainen

Glerean

Meskanen

et al. 2017

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

The link between neurotransmitter-level effects of antidepressants and their clinical effect remain poorly understood. A single dose of mirtazapine decreases limbic responses to fearful faces in healthy subjects, but it is unknown whether this effect applies to complex emotional situations and dynamic connectivity between brain regions. Thirty healthy volunteers listened to spoken emotional narratives during functional magnetic resonance imaging (fMRI). In an open-label design, 15 subjects received 15mg of mirtazapine two hours prior to fMRI while 15 subjects served as a control group. We assessed the effects of mirtazapine on regional neural responses and dynamic functional connectivity associated with valence and arousal. Mirtazapine attenuated responses to unpleasant events in the right fronto-insular cortex, while modulating responses to arousing events in the core limbic regions and the cortical midline structures (CMS). Mirtazapine decreased responses to unpleasant and arousing events in sensorimotor areas and the anterior CMS implicated in self-referential processing and formation of subjective feelings. Mirtazapine increased functional connectivity associated with positive valence in the CMS and limbic regions. Mirtazapine triggers large-scale changes in regional responses and functional connectivity during naturalistic, emotional stimuli. These span limbic, sensorimotor, and midline brain structures, and may be relevant to the clinical effectiveness of mirtazapine.

show abstract

Section: Effect Of Mirtazapine On Large-scale Functional Connectivitysupporting

confidence: 63%

Single dose of mirtazapine modulates whole-brain functional connectivity during emotional narrative processing

Komulainen

Glerean

Meskanen

et al. 2017

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Conversely, non-remitters showed much lower levels of significant changes. It suggested that treatment response might be associated with activity in the occipital resting-state network [29]. In the present study, compared with the MDD patients with mild treatment resistance, the patients with moderate-to-severe resistance had greater 18 F-florbetapir binding in the temporal and occipital regions.…”

Section: Discussionmentioning

confidence: 50%

Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study

et al. 2017

View full text Add to dashboard Cite

BackgroundLack of treatment response in patients with late-life depression is common. The role of brain beta-amyloid (Aβ) deposition in treatment outcome in subjects with late-life depression remains unclear. The present study aimed to investigate brain Aβ deposition in patients with major depressive disorder (MDD) with differing treatment outcomes in vivo using 18F-florbetapir imaging.This study included 62 MDD patients and 18 healthy control subjects (HCs).We first employed the Maudsley staging method (MSM) to categorize MDD patients into two groups according to treatment response: mild treatment resistance (n = 29) and moderate-to-severe treatment resistance (n = 33).The standard uptake value ratio (SUVR) of each volume of interest was analysed, and voxel-wise comparisons were made between the MDD patients and HCs. Vascular risk factors, serum homocysteine level, and apolipoprotein E (ApoE) genotype were also determined.ResultsThe MDD patients with moderate-to-severe treatment resistance had higher 18F-florbetapir SUVRs than the HCs in the parietal region (P < 0.01). Voxel-wise comparisons further demonstrated elevated SUVRs in MDD patients with moderate-to-severe treatment resistance in the precuneus, parietal, temporal, and occipital regions. The MDD patients with mild treatment resistance were found to have increased 18F-florbetapir uptake mainly in the left frontal and parietal regions as compared with the HCs. In addition, voxel-to-voxel correlation analysis showed that brain Aβ deposition was correlated positively with MSM score in the occipital region. 18F-florbetapir SUVRs were correlated negatively with Mini Mental Status Examination (MMSE) score in the sample of all MDD patients (r = −0.355, P = 0.005).ConclusionsThis study provided preliminary evidence that region-specific Aβ deposition was present in some (but not all) MDD patients, especially in those with moderate-to-severe treatment resistance, and their depressive symptoms may represent prodromal manifestations of Alzheimer’s disease (AD). Depressive symptomatology in old age, particularly in subjects with a poor treatment response, may underscore early changes of AD-related pathophysiology.

show abstract

“…We measured spontaneous brain activity via a fractional ALFF (fALFF) approach (Zou et al, 2008). This approach could improve the sensitivity and specificity in detecting regional spontaneous brain activity compared to ALFF (Zou et al, 2008), and has been widely used in major depressive disorder (Cheng et al, 2017;Qiu et al, 2019), schizophrenia (Hoptman et al, 2010;Zhang et al, 2018), Parkinson's disease (Tang et al, 2017;Guo et al, 2018) and other neuropsychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Distinct Spontaneous Brain Activity Patterns in Different Biologically-Defined Alzheimer’s Disease Cognitive Stage: A Preliminary Study

Zeng

Luo

et al. 2019

Front. Aging Neurosci.

View full text Add to dashboard Cite

Background: The National Institute on Aging-Alzheimer's Association (NIA-AA) has proposed a biological definition of Alzheimer's disease (AD): individuals with both abnormal amyloid and tau biomarkers (A+T+) would be defined as AD. It remains unclear why different cognitive status is present in subjects with biological AD. Resting-state functional magnetic resonance imaging (rsfMRI) has provided an opportunity to reveal the brain activity patterns in a biologically-defined AD cohort. Accordingly, we aimed to investigate distinct brain activity patterns in subjects with existed AD pathology but in the different cognitive stages. Method: We selected individuals with AD pathology (A+T+) and healthy controls (HC, A−T−) based on the cerebrospinal fluid (CSF) biomarkers. According to the cognitive stage, we divided the A+T+ cohort into three groups: (1) preclinical AD; (2) prodromal AD; and (3) AD with dementia (d-AD). We compared spontaneous brain activity measured by a fractional amplitude of low-frequency fluctuation (fALFF) approach among four groups. Results: The analysis of covariance (ANCOVA) results showed significant differences in fALFF in the posterior cingulate cortex/precuneus (PCC/PCu). Further, compared to HC, we found increased fALFF values in the right inferior frontal gyrus (IFG) in the preclinical AD stage, whereas prodromal AD patients showed reduced fALFF in the bilateral precuneus, right middle frontal gyrus (MFG), right precentral gyrus, and postcentral gyrus. Within the dAD group, both hyperactivity (right fusiform gyrus, right parahippocampal gyrus (PHG)/hippocampus, and inferior temporal gyrus) and hypoactivity (bilateral precuneus, left posterior cingulate cortex, left cuneus and superior occipital gyrus) were detected.

show abstract

Resting-state brain alteration after a single dose of SSRI administration predicts 8-week remission of patients with major depressive disorder

Abstract: This study revealed the possibility of using the measurement of resting-state neural changes a few hours after acute administration of antidepressant to identify individuals likely to remit after a few weeks of treatment.

Cited by 43 publications

References 62 publications

Single dose of mirtazapine modulates whole-brain functional connectivity during emotional narrative processing

Single dose of mirtazapine modulates whole-brain functional connectivity during emotional narrative processing

Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study

Distinct Spontaneous Brain Activity Patterns in Different Biologically-Defined Alzheimer’s Disease Cognitive Stage: A Preliminary Study

Contact Info

Product

Resources

About