Resting state default mode network connectivity in children and adolescents with <scp>ADHD</scp> after acute tryptophan depletion

Biskup, C.S.; Helmbold, K.; Baurmann, D.; Klasen, Martin; Gaber, Tilman J.; Bubenzer-Busch, S.; Königschulte, W.; Fink, Gereon R.; Zepf, Florian Daniel

doi:10.1111/acps.12573

Cited by 22 publications

(22 citation statements)

References 78 publications

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“…However, 5-HT has been shown to have an important role in the underlying pathophysiology of ADHD. More recently, Biskup et al (11) administered young people with ADHD and controls the ATD challenge and a balanced amino acid mixture. Following this, resting-state fMRI data were obtained.…”

Section: Brain Regions and Neurotransmittersmentioning

confidence: 99%

Attention‐deficit/hyperactivity disorder and the encoding of emotional information

Runions

Rao

Wong

et al. 2017

Acta Psychiatr Scand

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Section: Brain Regions and Neurotransmittersmentioning

confidence: 99%

Attention‐deficit/hyperactivity disorder and the encoding of emotional information

Runions

Rao

Wong

et al. 2017

Acta Psychiatr Scand

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Section: Region Of Interestmentioning

confidence: 99%

“…Imaging and behavioral studies have demonstrated that serotonergic neurotransmission affect impulsive behavior [Dalley and Roiser, 2012], motor planning and sensory perception [Biskup et al, 2016] and modulates the default mode network [Hahn et al, 2010]. Recently, it has been found that, compared to HC, patients with ADHD show elevated functional connectivity of the default mode network and attenuated functional connectivity in a state of diminished brain serotonin levels, evoked through acute tryptophan depletion [Biskup et al, 2016]. We found a higher molecular correlation of the SERT between the precuneus and the hippocampus in patients with ADHD and in general lower correlations in HC, which may reflect higher impulsivity in patients and might be explained by a more diverse, region specific modulated serotonergic system in HC and by more rigid and less variable serotonergic signaling in ADHD.…”

Section: Region Of Interestmentioning

confidence: 99%

Altered interregional molecular associations of the serotonin transporter in attention deficit/hyperactivity disorder assessed with PET

et al. 2016

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Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well as increased motor activity, all exemplifying key symptoms of ADHD. The main objectives of this positron emission tomography (PET) study were to investigate the serotonin transporter binding potential (SERT BP ) in patients with ADHD and to assess associations of SERT BP between the brain regions. 25 medication-free patients with ADHD (age ± SD; 32.39 ± 10.15; 10 females) without any psychiatric comorbidity and 25 age and sex matched healthy control subjects (33.74 ± 10.20) were measured once with PET and the highly selective and specific radioligand [ C]DASB. SERT BP maps in nine a priori defined ROIs exhibiting high SERT binding were compared between groups by means of a linear mixed model. Finally, adopted from structural and functional connectivity analyses, we performed correlational analyses using regional SERT binding potentials to examine molecular interregional associations between all selected ROIs. We observed significant differences in the interregional correlations between the precuneus and the hippocampus in patients with ADHD compared to healthy controls, using SERT BP of the investigated ROIs (P < 0.05; Bonferroni corrected). When correlating SERT BP and age in the ADHD and the healthy control group, we confirmed an age-related decline in brain SERT binding in the thalamus and insula (R = 0.284, R = 0.167, Ps < 0.05; Bonferroni corrected). The results show significantly different interregional molecular associations of the SERT expression for the precuneus with hippocampus in patients with ADHD, indicating presumably altered functional coupling. Altered interregional coupling between brain regions might be a sensitive approach to demonstrate functional and molecular alterations in psychiatric conditions. Hum Brain Mapp 38:792-802, 2017. © 2016 Wiley Periodicals, Inc.

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“…Research on the role of the amino acid (AA) tryptophan (TRP, the physiological precursor of 5-HT) and related brain 5-HT synthesis) have used acute tryptophan depletion (ATD). ATD is a physiological serotonergic challenge procedure that has been widely used over the last decade to investigate the role of 5-HT in a variety of disorders, in both children and adolescents (10,11), and adults (9,12). Additionally, ATD allows investigations into the role of 5-HT on various behavioral and cognitive processes.…”

Section: Introductionmentioning

confidence: 99%

Acute Tryptophan Depletion Moja-De: A Method to Study Central Nervous Serotonin Function in Children and Adolescents

et al. 2020

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Serotonin (5-HT) is widely implicated as a key neurotransmitter relevant to a range of psychiatric disorders and psychological processes. The role of central nervous 5-HT function underlying these processes can be examined through serotonergic challenge methodologies. Acute tryptophan depletion (ATD) is a key challenge method whereby a diminished dietary intake of tryptophan-the amino acid precursor to brain 5-HT synthesis-results in temporary diminished central nervous 5-HT synthesis. While this particular methodology has been used in adult populations, it was only recently that modifications were made to enable the use of ATD in child and adolescent populations. Additionally, the Moja-De modification of the ATD challenge methodology has demonstrated benefits over other ATD techniques used previously. The aim of this protocol paper is to describe the ATD Moja-De methodology in detail, its benefits, as well as studies that have been conducted to validate the procedure in child and adolescent samples. The ATD Moja-De protocol provides a potential methodology for investigating the role of central nervous 5-HT via manipulation of brain tryptophan availability in human psychopathology from a developmental viewpoint.

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Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion

Abstract: Data reveal a serotonergic modulation of FC between BA 6 and 3, known to be relevant for motor planning and sensory perception, and the DMN, thereby possibly pointing toward ATD acting beneficially on neural planning of motor activity in patients with ADHD.

Cited by 22 publications

References 78 publications

Attention‐deficit/hyperactivity disorder and the encoding of emotional information

Attention‐deficit/hyperactivity disorder and the encoding of emotional information

Altered interregional molecular associations of the serotonin transporter in attention deficit/hyperactivity disorder assessed with PET

Acute Tryptophan Depletion Moja-De: A Method to Study Central Nervous Serotonin Function in Children and Adolescents

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