Resting state EEG abnormalities in autism spectrum disorders

Wang, Jun; Barstein, Jamie; Ethridge, Lauren E.; Mosconi, Matthew W.; Takarae, Yukari; Sweeney, John A.

doi:10.1186/1866-1955-5-24

Cited by 403 publications

(381 citation statements)

References 163 publications

(233 reference statements)

Supporting

Mentioning

340

Contrasting

Unclassified

Order By: Relevance

“…The baseline decreased resting state a power was consistent with other EEG studies in ASD. 25,26 Moreover, a role for a frequency band oscillations has been shown in specific cognitive mechanisms. 27 The increase in the a frequency power after treatment may be an underlying mechanism of patient's improvement in cognition and behavior.…”

Section: Discussionmentioning

confidence: 99%

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

Bruining¹,

Passtoors²,

Goriounova

et al. 2015

Pediatrics

View full text Add to dashboard Cite

The diuretic agent bumetanide has recently been put forward as a novel, promising treatment of behavioral symptoms in autism spectrum disorder (ASD) and related conditions. Bumetanide can decrease neuronal chloride concentrations and may thereby reinstate g-aminobutyric acid (GABA)-ergic inhibition in patients with neurodevelopmental disorders. However, strategies to select appropriate candidates for bumetanide treatment are lacking. We hypothesized that a paradoxical response to GABA-enforcing agents such as benzodiazepines may predict the efficacy of bumetanide treatment in neurodevelopmental disorders. We describe a case of a 10-year-old girl with ASD, epilepsy, cortical dysplasia, and a 15q11.2 duplication who had exhibited marked behavioral arousal after previous treatment with clobazam, a benzodiazepine. We hypothesized that this response indicated the presence of depolarizing excitatory GABA and started bumetanide treatment with monitoring of behavior, cognition, and EEG. The treatment resulted in a marked clinical improvement in sensory behaviors, rigidity, and memory performance, which was substantiated by questionnaires and cognitive assessments. At baseline, the girl's EEG showed a depression in absolute a power, an electrographic sign previously related to ASD, which was normalized with bumetanide treatment. The effects of bumetanide on cognition and EEG seemed to mirror the "nonparadoxical" responses to benzodiazepines in healthy subjects. In addition, temporal lobe epilepsy and cortical dysplasia have both been linked to disturbed chloride homeostasis and seem to support our assumption that the observed paradoxical response was due to GABA-mediated excitation. This case highlights that a paradoxical behavioral response to GABA-enforcing drugs may constitute a framework for targeted treatment with bumetanide. PATIENT PRESENTATIONThe patient, a 10-year-old girl, was the fourth child of nonconsanguineous healthy parents. The family history was unremarkable, and the pregnancy and birth were uneventful. The child displayed an apparently normal development up to 4 years of age, when she began experiencing epileptic seizures. She was diagnosed with focal epilepsy with right temporoparietal localization, with focal seizures occurring in clusters.An MRI revealed a focal cortical dysplasia of the right temporal lobe. Coinciding with the onset of epilepsy, learning difficulty and behavioral rigidity emerged but were not evaluated at that time by a child psychiatrist. At the age of 8 years, she was referred to our clinic for diagnostic evaluation of increasing learning disability, behavioral inflexibility, and emotional disturbance. We observed a delay in language development, rigidity, and repetitive behaviors with peculiar

show abstract

Section: Discussionmentioning

confidence: 99%

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

Bruining¹,

Passtoors²,

Goriounova

et al. 2015

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Ongoing neural activity can be assessed noninvasively during a resting-state EEG recording, i.e., in the absence of task performance or sensory stimulation, in which patterns of neural oscillations may be detected [2]. It has been suggested that elevated oscillatory activity in ASD might indicate hyperactivity in cortical circuits, and subsequently may be associated with the ''autistic'' state [3,4], which is in agreement with a recent review summarizing EEG abnormalities during resting-state paradigms in ASD, reporting increased power in low (delta, theta) and high frequencies (beta, gamma) and reduced activity in middlerange frequencies (alpha) [2]. A few experimental studies report altered resting-state gamma activity by EEG or MEG.…”

Section: Introductionmentioning

confidence: 99%

Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

Diessen

Senders

Jansen

et al. 2014

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Experimental studies suggest that increased resting-state power of gamma oscillations is associated with autism spectrum disorder (ASD). To extend the clinical applicability of this finding, we retrospectively investigated routine electroencephalography (EEG) recordings of 19 patients with ASD and 19 age-and gender-matched controls. Relative resting-state condition gamma spectral power was variable, but on average significantly increased in children with ASD. This effect remained when excluding electrodes associated with myogenic gamma activity. These findings further indicate that increased resting-state gamma activity characterizes a subset of ASD and may also be detected by routine EEG as a clinically accessible and well-tolerated investigation.

show abstract

“…Interestingly, alterations in gamma power have been Identified among other disorders that share some, but not all features of schizophrenia. Specifically, people with autism spectrum disorders (ASD) also display increased background gamma power, but do not experience hallucinations and delusions (Wang et al, 2013;van Diessen et al, 2014). We propose that the developmental timing during which increased background activity emerges determines the types of subjective and functional abnormalities that result.…”

Section: Discussionmentioning

confidence: 99%

Cellular and Circuit Models of Increased Resting State Network Gamma Activity in Schizophrenia

White

Siegel

2016

The Neurobiology of Schizophrenia

View full text Add to dashboard Cite

Resting state EEG abnormalities in autism spectrum disorders

Cited by 403 publications

References 163 publications

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?

Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography

Cellular and Circuit Models of Increased Resting State Network Gamma Activity in Schizophrenia

Contact Info

Product

Resources

About