Resting state fMRI correlates of Theory of Mind impairment in amyotrophic lateral sclerosis

Trojsi, Francesca; Nardo, Federica Di; Santangelo, Gabriella; Siciliano, Mattia; Femiano, Cinzia; Passaniti, Carla; Caiazzo, Giuseppina; Fratello, Michele; Cirillo, Mario; Monsurrò, Maria Rosaria; Esposito, Fabrizio; Tedeschi, Gioacchino

doi:10.1016/j.cortex.2017.09.016

Cited by 41 publications

(45 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As regards the association between RS-FC and social cognition tasks, the results confirm that DMN is involved in social cognition abilities in MS, consistently with other previous studies with healthy subjects and with patients affected by neurological diseases, such as amyotrophic lateral sclerosis (Li et al, 2014;Trojsi et al, 2017). In more detail, we observed that more difficulties in understanding the concept of the social norm of reciprocity in interpersonal relationships were associated with reduced RS-FC in the right middle temporal gyrus, which belongs to DMN.…”

Section: Discussionsupporting

confidence: 90%

“…In the present study, we also observed a negative association between another node of the DMN, the PCC, and performance on first-order ToM: patients with an increased connectivity in this node performed worse on tasks that require differentiating between their own and others' mental states. PCC is involved in outcome monitoring and in social cognition as revealed in studies performed on HC and in patients with neurological diseases, such as amyotrophic lateral sclerosis (Maddock et al, 2003;Kable and Glimcher, 2007;Trojsi et al, 2017). Moreover, the involvement of PCC in social cognition in MS was also confirmed by a previous fMRI meta-analytic study where an activation of the PCC was described during the execution of non-verbal false belief stories tasks (Schurz et al, 2014).…”

Section: Discussionmentioning

confidence: 58%

“…Social cognition deficits occur in several neurological diseases such as amyotrophic lateral sclerosis (Trojsi et al, 2017), Parkinson's disease (PD; Bora et al, 2015), behavioral-variant frontotemporal dementia (Henry et al, 2014) and multiple sclerosis (MS; Henry et al, 2009Henry et al, , 2011Banati et al, 2010;Pöttgen et al, 2013;Bora et al, 2016;Cotter et al, 2016). In MS, it is unclear whether (cognitive and affective) aspects of social cognition are both impaired: some studies found that the two subcomponents are equally impaired (Raimo et al, 2017), while others revealed deficits only on a single subcomponent, either cognitive (Roca et al, 2013) or affective (Cotter et al, 2016).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study

Bisecco

Altieri

Santangelo

et al. 2020

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 58%

mentioning

confidence: 99%

See 1 more Smart Citation

Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study

Bisecco

Altieri

Santangelo

et al. 2020

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In accordance with findings for cognitive flexibility reported above, meta-analyses proved a lower performance of ALS-patients in different measures of ToM-PT compared to healthy controls ( 67 , 132 ). This finding is confirmed by a recent study for early-stage ALS-patients ( 136 ) while again nothing is known yet in very advanced stages. Deficits are repeatedly reported to be more pronounced in ALS with bulbar onset ( 125 , 132 , 136 , 137 ) and therefore in the subgroup of patients that is more frequently or earlier dependent of HT-AAC support for communication.…”

Section: Cognitive and Behavioral Impairment And Its Consequences Forsupporting

confidence: 77%

Communication Matters—Pitfalls and Promise of Hightech Communication Devices in Palliative Care of Severely Physically Disabled Patients With Amyotrophic Lateral Sclerosis

Linse

Aust

Joos³

et al. 2018

Front. Neurol.

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, leading to progressive paralysis, dysarthria, dysphagia, and respiratory disabilities. Therapy is mostly focused on palliative interventions. During the course of the disease, verbal as well as nonverbal communicative abilities become more and more impaired. In this light, communication has been argued to be “the essence of human life” and crucial for patients' quality of life. High-tech augmentative and alternative communication (HT-AAC) technologies such as eyetracking based computer devices and brain-computer-interfaces provide the possibility to maintain caregiver-independent communication and environmental control even in the advanced disease state of ALS. Thus, they enable patients to preserve social participation and to independently communicate end-of-life-decisions. In accordance with these functions of HT-AAC, their use is reported to strengthen self-determination, increase patients' quality of life and reduce caregiver burden. Therefore, HT-AAC should be considered as standard of (palliative) care for people with ALS. On the other hand, the supply with individually tailored HT-AAC technologies is limited by external and patient-inherent variables. This review aims to provide an overview of the possibilities and limitations of HT-AAC technologies and discuss their role in the palliative care for patients with ALS.

show abstract

“…Interestingly, the core areas of bvFTD that showing prominent atrophy are located close to regions with convergent gray matter atrophy between bvFTD and ALS. It has been revealed that ALS patients who scored significantly lower in social cognitive performances during follow-up, exhibited abnormal functional connectivity at baseline within cognitive networks similar to those described in early bvFTD, including frontolimbic networks (Trojsi et al, 2015(Trojsi et al, , 2017. We speculate that early damage of these overlapping regions makes ALS patients more prone to developing cognitive and/or behavioral impairments in the later stages of the disease, and FTD development in ALS is likely to be accompanied by progressive atrophy in the frontomedialcaudate circuit.…”

Section: Discussionmentioning

confidence: 92%

Comparison of Gray Matter Atrophy in Behavioral Variant Frontal Temporal Dementia and Amyotrophic Lateral Sclerosis: A Coordinate-Based Meta-Analysis

Chen

Xiao

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Background: There is growing evidence supporting behavioral variant frontotemporal dementia (bvFTD) and amyotrophic lateral sclerosis (ALS) as extreme points of a disease spectrum. The aim of this study was to delineate the common and different patterns of gray matter atrophy associated with bvFTD and with ALS by pooling together the results of previous voxel-based morphometry (VBM) studies. Methods:We retrieved VBM studies that investigated gray matter atrophy in bvFTD patients vs. controls and in ALS patients vs. controls. Stereotactic data were extracted from those studies and subsequently tested for convergence and differences using activation likelihood estimation (ALE). A behavioral analysis using the BrainMap database was performed to assess the functional roles of the regions affected by bvFTD and/or ALS.Results: Our study demonstrated a convergence of gray matter atrophy in the frontolimbic structures that involve the bilateral anterior insula and anterior cingulate cortex. Comparing the pattern of GM atrophy in bvFTD and ALS patients revealed greater atrophy in the frontomedial cortex, bilateral caudate, left anterior insula, and right thalamus in those with bvFTD and a higher degree of atrophy in the right motor cortex of those with ALS. Behavioral analysis revealed that the pattern of the affected regions contributed to the dysfunction of emotional and cognitive processing in bvFTD patients and the dysfunction of motor execution in ALS patients. Conclusion:Our results revealed a shared neural basis between bvFTD and ALS subjects, as well as a specific and distinct neural signature that underpinned the clinical manifestations of those two diseases. Those findings outlined the role of the frontomedial-caudate circuit in the development of bvFTD-like deficits in ALS patients.

show abstract

Resting state fMRI correlates of Theory of Mind impairment in amyotrophic lateral sclerosis

Cited by 41 publications

References 115 publications

Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study

Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study

Communication Matters—Pitfalls and Promise of Hightech Communication Devices in Palliative Care of Severely Physically Disabled Patients With Amyotrophic Lateral Sclerosis

Comparison of Gray Matter Atrophy in Behavioral Variant Frontal Temporal Dementia and Amyotrophic Lateral Sclerosis: A Coordinate-Based Meta-Analysis

Contact Info

Product

Resources

About