Resting state fMRI reveals increased subthalamic nucleus–motor cortex connectivity in Parkinson's disease

Baudrexel, Simon; Witte, Torsten; Seifried, Carola; Wegner, Frederic von; Beißner, Florian; Klein, Johannes; Steinmetz, Helmuth; Deichmann, Ralf; Roeper, Jochen; Hilker, Rüdiger

doi:10.1016/j.neuroimage.2011.01.017

Cited by 219 publications

(217 citation statements)

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“…It is therefore not surprising that we observed differences in basal ganglia connectivity with laryngeal motor cortex when comparing PDSI subjects to PDN subjects. One possibility is that increased connectivity between the two structures is in fact related to the disease process, similar to the observed hyperconnectivity of the subthalamic nucleus to motor cortices in PD (Baudrexel et al., 2011; Kurani et al., 2015). However, in the context of compensatory effects, it is also possible that PDSI subjects require greater coupling between left GPi and left laryngeal motor cortex in order to overcome disease‐related changes in voice production (e.g., hypophonia).…”

Section: Discussionmentioning

confidence: 99%

“…It is well established that speech production involves the sensorimotor cortex, SMA, inferior frontal gyrus/ventral premotor cortex (PMv), superior temporal gyrus (STG)/Heschl's gyrus, and cerebellum (Brown, Ingham, Ingham, Laird, & Fox, 2005; Brown et al., 2009; Manes et al., 2014; Tourville & Guenther, 2011) These regions of the cortex are reliably active during speech and voice production tasks (Brown et al., 2005; Manes et al., 2014; Spaniol et al., 2009). Studies of whole‐brain resting‐state connectivity in PD have documented that the basal ganglia have abnormal connectivity to the cerebellum (Hacker, Perlmutter, Criswell, Ances, & Snyder, 2012) and motor cortices, including sensorimotor cortex (Baudrexel et al., 2011; Hacker et al., 2012; Kurani et al., 2015; Kwak et al., 2010), premotor cortex (Baudrexel et al., 2011), and SMA (Baudrexel et al., 2011; Hacker et al., 2012; Kwak et al., 2010). Given the critical role of these structures in speech production, it seems likely that changes in these connections contribute to speech problems in PD.…”

Section: Introductionmentioning

confidence: 99%

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Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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IntroductionSpeech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology.MethodsResting‐state data from 89 right‐handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls (“OHC”), 42 PD patients without speech impairment (“PDN”), and 35 PD subjects with speech impairment (“PDSI”). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III speech item scores (“0” vs. “1–4”). Whole‐brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group‐averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t‐tests were performed to determine differences between the three groups using a voxel‐wise threshold of p < 0.001 and cluster‐extent threshold of 272 mm3 (FWE<0.05).ResultsIn comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus.ConclusionsThe present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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“…allows the detection of functional changes in the CNS after traumatic brain injury where conventional MRI is incapable of showing any pathology (17)(18)(19). In preclinical rodent models, fMRI is primarily used to study brain function in a neuroscience setting (20).…”

Section: Introductionmentioning

confidence: 99%

Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease

Gessler¹,

Li²,

Xu³

et al. 2017

JCI Insight

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“…The study of functional connectivity (FC) in PD is relatively young (Baudrexel et al, 2011;Göttlich et al, 2013;Hacker et al, 2012;Helmich et al, 2010;Luo et al, 2014;Poston and Eidelberg, 2012;Sharman et al, 2013;Wu et al, 2009Wu et al, , 2011aWu et al, , 2012Yu et al, 2013). An early study evaluating resting-state FC (rsFC) in PD showed that rsFC between the pre-supplementary motor area (pre-SMA) and putamen was decreased, whereas that between the pre-SMA and primary motor cortex (M1) was increased (Wu et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity

et al. 2016

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Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's disease (PD). The efficacy is believed to be dependent on pedaling rate, with rates above the subjects' voluntary exercise rates being most beneficial. In this study, we use functional connectivity magnetic resonance imaging (MRI) to further elucidate the mechanism underlying this effect. Twenty-seven PD patients were randomized to complete 8 weeks of forced-rate exercise (FE) or voluntary-rate exercise (VE). Exercise was delivered using a specialized stationary bicycle, which can augment patients' voluntary exercise rates. The FE group received assistance from the cycle. Imaging was conducted at baseline, end of therapy, and after 4 weeks of follow-up. Functional connectivity (FC) was determined via seed-based correlation analysis, using activationbased seeds in the primary motor cortex (M1). The change in FC after exercise was compared using linear correlation with pedaling rate. Results of the correlation analysis showed a strong positive correlation between pedaling rate and change in FC from the most affected M1 to the ipsilateral thalamus. This effect persisted after 4 weeks of follow-up. These results indicate that a plausible mechanism for the therapeutic efficacy of high-rate exercise in PD is that it improves thalamo-cortical connectivity.

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Resting state fMRI reveals increased subthalamic nucleus–motor cortex connectivity in Parkinson's disease

Cited by 219 publications

References 71 publications

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease

Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity

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